PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response
PI3Kγ抑制剂可抑制胶质母细胞瘤微环境中小胶质细胞/肿瘤相关巨噬细胞(TAM)的积累,从而促进替莫唑胺的卓越疗效。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2009290118
Li, Jie; Kaneda, Megan M; Ma, Jun; Li, Ming; Shepard, Ryan M; Patel, Kunal; Koga, Tomoyuki; Sarver, Aaron; Furnari, Frank; Xu, Beibei; Dhawan, Sanjay; Ning, Jianfang; Zhu, Hua; Wu, Anhua; You, Gan; Jiang, Tao; Venteicher, Andrew S; Rich, Jeremy N; Glass, Christopher K; Varner, Judith A; Chen, Clark C
巨噬细胞
胶质细胞
肿瘤
肿瘤免疫
巨噬细胞
细胞生物学
免疫/内分泌