Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway
Aurora激酶A抑制剂alisertib（MLN8237）通过激活线粒体介导的通路和抑制p38 MAPK/PI3K/Akt/mTOR信号通路，对人骨肉瘤U-2 OS和MG-63细胞产生促凋亡和促自噬作用。
期刊:Drug Design Development and Therapy
影响因子:5.1
doi:10.2147/DDDT.S74197
Niu, Ning-Kui; Wang, Zi-Li; Pan, Shu-Ting; Ding, Hui-Qiang; Au, Giang H T; He, Zhi-Xu; Zhou, Zhi-Wei; Xiao, Guozhi; Yang, Yin-Xue; Zhang, Xueji; Yang, Tianxin; Chen, Xiao-Wu; Qiu, Jia-Xuan; Zhou, Shu-Feng
凋亡
mTOR
骨肉瘤
表观遗传
p38 MAPK
信号转导
PI3K/Akt
MAPK/ERK
线粒体
细胞生物学
自噬
