日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance

共靶向 SOS1 可通过解决内在和获得性耐药性增强 KRASG12C 抑制剂的抗肿瘤作用

Venu Thatikonda #, Hengyu Lyu #, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Christoph Albrecht, Donat Alpar, Heribert Arnhof, Oliver Bergner, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Melanie Hinkel, Simone Lieb, Astrid Jeschko, Annette A Machado, Thomas Madensk

A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer

TRAILR2/CDH3 双特异性抗体在 CDH3 阳性胰腺癌中表现出选择性凋亡和肿瘤消退

Peter Jung, Stefan P Glaser, Jing Han, Alexandra Popa, Laura Pisarsky, Ningping Feng, Antonia Geyer, Franziska Haderk, Donat Alpar, Christopher Bristow, Susanne Schmittner, Paula-Elena Traexler, Mikhila Mahendra, Birgit Poehn, Poojabahen Gandhi, Roberto Fiorelli, Sanket Awate, Nicole Budano, Florian

A conserved cell-type gradient across the human mediodorsal and paraventricular thalamus

人类丘脑内侧和室旁核中保守的细胞类型梯度

Anton Schulmann, Ningping Feng, Pavan K Auluck, Arghya Mukherjee, Ruchi Komal, Yan Leng, Claire Gao, Sarah K Williams Avram, Snehashis Roy, Ted B Usdin, Qing Xu, Vesna Imamovic, Yash Patel, Nirmala Akula, Armin Raznahan, Vilas Menon, Panos Roussos, Laramie Duncan, Abdel Elkahloun, Jatinder Singh, Mi

KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

KRASG12D抑制可重编程早期和晚期胰腺癌的微环境,从而促进CD8+ T细胞介导的FAS杀伤作用

Krishnan K Mahadevan ,Kathleen M McAndrews ,Valerie S LeBleu ,Sujuan Yang ,Hengyu Lyu ,Bingrui Li ,Amari M Sockwell ,Michelle L Kirtley ,Sami J Morse ,Barbara A Moreno Diaz ,Michael P Kim ,Ningping Feng ,Anastasia M Lopez ,Paola A Guerrero ,Francesca Paradiso ,Hikaru Sugimoto ,Kent A Arian ,Haoqiang Ying ,Yasaman Barekatain ,Lakshmi Kavitha Sthanam ,Patience J Kelly ,Anirban Maitra ,Timothy P Heffernan ,Raghu Kalluri

Ether phospholipids are required for mitochondrial reactive oxygen species homeostasis

醚磷脂是线粒体活性氧稳态所必需的。

Ziheng Chen ,I-Lin Ho ,Melinda Soeung ,Er-Yen Yen ,Jintan Liu ,Liang Yan ,Johnathon L Rose ,Sanjana Srinivasan ,Shan Jiang ,Q Edward Chang ,Ningping Feng ,Jason P Gay ,Qi Wang ,Jing Wang ,Philip L Lorenzi ,Lucas J Veillon ,Bo Wei ,John N Weinstein ,Angela K Deem ,Sisi Gao ,Giannicola Genovese ,Andrea Viale ,Wantong Yao ,Costas A Lyssiotis ,Joseph R Marszalek ,Giulio F Draetta ,Haoqiang Ying

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

KRASG12C 和 SOS1 联合抑制可通过解决内在和获得性耐药性来增强和延长 KRASG12C 驱动癌症的抗肿瘤反应

Venu Thatikonda, Hengyu Lu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Simone Lieb, Astrid Jeschko, Annette A Machado, Ethan D Marszalek, Mikhila Mahendra, Philipp A Jaeger, Alexey Sorokin, Sandra Strauss, Francesca Trap

Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia

抑制线粒体复合物 I 可逆转 NOTCH1 驱动的 T 细胞急性淋巴细胞白血病代谢重编程

Natalia Baran ,Alessia Lodi ,Yogesh Dhungana ,Shelley Herbrich ,Meghan Collins ,Shannon Sweeney ,Renu Pandey ,Anna Skwarska ,Shraddha Patel ,Mathieu Tremblay ,Vinitha Mary Kuruvilla ,Antonio Cavazos ,Mecit Kaplan ,Marc O Warmoes ,Diogo Troggian Veiga ,Ken Furudate ,Shanti Rojas-Sutterin ,Andre Haman ,Yves Gareau ,Anne Marinier ,Helen Ma ,Karine Harutyunyan ,May Daher ,Luciana Melo Garcia ,Gheath Al-Atrash ,Sujan Piya ,Vivian Ruvolo ,Wentao Yang ,Sriram Saravanan Shanmugavelandy ,Ningping Feng ,Jason Gay ,Di Du ,Jun J Yang ,Fieke W Hoff ,Marcin Kaminski ,Katarzyna Tomczak ,R Eric Davis ,Daniel Herranz ,Adolfo Ferrando ,Elias J Jabbour ,M Emilia Di Francesco ,David T Teachey ,Terzah M Horton ,Steven Kornblau ,Katayoun Rezvani ,Guy Sauvageau ,Mihai Gagea ,Michael Andreeff ,Koichi Takahashi ,Joseph R Marszalek ,Philip L Lorenzi ,Jiyang Yu ,Stefano Tiziani ,Trang Hoang ,Marina Konopleva

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

PRMT1依赖的RNA代谢和DNA损伤反应调控维持胰腺导管腺癌

Virginia Giuliani,Meredith A Miller #,Chiu-Yi Liu #,Stella R Hartono #,Caleb A Class,Christopher A Bristow,Erika Suzuki,Lionel A Sanz,Guang Gao,Jason P Gay,Ningping Feng,Johnathon L Rose,Hideo Tomihara,Joseph R Daniele,Michael D Peoples,Jennifer P Bardenhagen,Mary K Geck Do,Qing E Chang,Bhavatarini Vangamudi,Christopher Vellano,Haoqiang Ying,Angela K Deem,Kim-Anh Do,Giannicola Genovese,Joseph R Marszalek,Jeffrey J Kovacs,Michael Kim,Jason B Fleming,Ernesto Guccione,Andrea Viale,Anirban Maitra,M Emilia Di Francesco,Timothy A Yap,Philip Jones,Giulio Draetta,Alessandro Carugo,Frederic Chedin,Timothy P Heffernan

Short-term treatment with multi-drug regimens combining BRAF/MEK-targeted therapy and immunotherapy results in durable responses in Braf-mutated melanoma

BRAF/MEK 靶向治疗和免疫治疗相结合的多药方案短期治疗可使 Braf 突变黑色素瘤获得持久缓解

Michael G White, Robert Szczepaniak Sloane, Russell G Witt, Alexandre Reuben, Pierre Olivier Gaudreau, Miles C Andrews, Ningping Feng, Sarah Johnson, Caleb A Class, Christopher Bristow, Khalida Wani, Courtney Hudgens, Luigi Nezi, Teresa Manzo, Mariana Pettaccia De Macedo, Jianhua Hu, Richard Davis, 

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

发现具有优异药代动力学和物理化学性质的临床阶段选择性谷氨酰胺酶-1 (GLS-1) 抑制剂 IPN60090

Michael J Soth, Kang Le, Maria Emilia Di Francesco, Matthew M Hamilton, Gang Liu, Jason P Burke, Chris L Carroll, Jeffrey J Kovacs, Jennifer P Bardenhagen, Christopher A Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R Garvey, Jason P Gay, Mary K Geck Do, Jennifer Gre