日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

线粒体ABHD11抑制驱动甾醇代谢,从而调节T细胞效应功能

Benjamin J Jenkins # ,Yasmin R Jenkins # ,Fernando M Ponce-Garcia ,Chloe Moscrop ,Iain A Perry ,Matthew D Hitchings ,Alejandro H Uribe ,Federico Bernuzzi ,Simon Eastham ,James G Cronin ,Ardena Berisha ,Alexandra Howell ,Joanne Davies ,Julianna Blagih ,Marta Williams ,Morgan Marsden ,Douglas J Veale ,Luke C Davies ,Micah Niphakis ,David K Finlay ,Linda V Sinclair ,Benjamin F Cravatt ,Andrew E Hogan ,James A Nathan ,Ian R Humphreys ,Ursula Fearon ,David Sumpton ,Johan Vande Voorde ,Goncalo Dias do Vale ,Jeffrey G McDonald ,Gareth W Jones ,James A Pearson ,Emma E Vincent ,Nicholas Jones

Attenuating ABHD17 isoforms augments the S-acylation and function of NOD2 and a subset of Crohn's disease-associated NOD2 variants

减弱 ABHD17 同工型可增强 NOD2 和克罗恩病相关 NOD2 变体的 S-酰化和功能

Charneal L Dixon, Noah R Martin, Micah J Niphakis, Benjamin F Cravatt, Gregory D Fairn

In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer.

体内验证棕榈酰化循环作为 NRAS 突变癌症的治疗靶点

Decker Matthew, Huang Benjamin J, Ware Timothy, Boone Christopher, Tang Michelle, Ybarra Julia, Ballapuram Aishwarya C, Taran Katrine A, Chen Pan-Yu, Amendáriz Marcos, Leung Camille J, Harris Max, Tjoa Karensa, Hongo Henry, Abelson Sydney, Rivera Jose, Ngo Nhi, Herbst Dylan M, Suciu Radu M, Guijas Carlos, Sedighi Kimia, Andalis Taylor, Roche Elysia, Xie Boer, Liu Yunlong, Smith Catherine C, Stieglitz Elliot, Niphakis Micah J, Cravatt Benjamin F, Shannon Kevin

ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity.

ABHD11抑制驱动甾醇代谢,从而调节T细胞效应功能并缓解自身免疫

Jenkins Benjamin J, Jenkins Yasmin R, Ponce-Garcia Fernando M, Moscrop Chloe, Perry Iain A, Hitchings Matthew D, Uribe Alejandro H, Bernuzzi Federico, Eastham Simon, Cronin James G, Berisha Ardena, Howell Alexandra, Davies Joanne, Blagih Julianna, Veale Douglas J, Davies Luke C, Niphakis Micah, Finlay David K, Sinclair Linda V, Cravatt Benjamin F, Hogan Andrew E, Nathan James A, Fearon Ursula, Sumpton David, Vande Voorde Johan, Dias do Vale Goncalo, McDonald Jeffrey G, Jones Gareth W, Pearson James A, Vincent Emma E, Jones Nicholas

Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

炎症通过干扰素调节因子 3 (IRF3) 介导的 FAHFA 水平降低导致小鼠产生胰岛素抵抗

Shuai Yan, Anna Santoro, Micah J Niphakis, Antonio M Pinto, Christopher L Jacobs, Rasheed Ahmad, Radu M Suciu, Bryan R Fonslow, Rachel A Herbst-Graham, Nhi Ngo, Cassandra L Henry, Dylan M Herbst, Alan Saghatelian, Barbara B Kahn, Evan D Rosen

Ligand discovery by activity-based protein profiling

基于活性蛋白质谱分析的配体发现

Niphakis, Micah J; Cravatt, Benjamin F

A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation

援助之手:MAGL 抑制对 HIV-1 相关神经炎症的治疗潜力

Alexis F League, Barkha J Yadav-Samudrala, Ramya Kolagani, Calista A Cline, Ian R Jacobs, Jonathan Manke, Micah J Niphakis, Benjamin F Cravatt, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fitting

Inhibitory Neurotransmission Is Sex-Dependently Affected by Tat Expression in Transgenic Mice and Suppressed by the Fatty Acid Amide Hydrolase Enzyme Inhibitor PF3845 via Cannabinoid Type-1 Receptor Mechanisms

抑制性神经传递受转基因小鼠中 Tat 表达的性别影响,并受脂肪酸酰胺水解酶抑制剂 PF3845 通过大麻素 1 型受体机制抑制

Changqing Xu, Barkha J Yadav-Samudrala, Callie Xu, Bhupendra Nath, Twisha Mistry, Wei Jiang, Micah J Niphakis, Benjamin F Cravatt, Somnath Mukhopadhyay, Aron H Lichtman, Bogna M Ignatowska-Jankowska, Sylvia Fitting

ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth

ABHD17 调控质膜棕榈酰化和 N-Ras 依赖性癌症生长

Jarrett R Remsberg # ,Radu M Suciu # ,Noemi A Zambetti # ,Thomas W Hanigan ,Ari J Firestone ,Anagha Inguva ,Amanda Long ,Nhi Ngo ,Kenneth M Lum ,Cassandra L Henry ,Stewart K Richardson ,Marina Predovic ,Ben Huang ,Melissa M Dix ,Amy R Howell ,Micah J Niphakis ,Kevin Shannon ,Benjamin F Cravatt

Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host

弓形虫丝氨酸水解酶在宿主体内生长和复制过程中调节寄生虫的脂质动员。

Ouma Onguka ,Brett M Babin ,Markus Lakemeyer ,Ian T Foe ,Neri Amara ,Stephanie M Terrell ,Kenneth M Lum ,Piotr Cieplak ,Micah J Niphakis ,Jonathan Z Long ,Matthew Bogyo