日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer.

体内验证棕榈酰化循环作为 NRAS 突变癌症的治疗靶点

期刊:
影响因子:
doi:10.1101/2025.03.20.644389
Decker Matthew, Huang Benjamin J, Ware Timothy, Boone Christopher, Tang Michelle, Ybarra Julia, Ballapuram Aishwarya C, Taran Katrine A, Chen Pan-Yu, Amendáriz Marcos, Leung Camille J, Harris Max, Tjoa Karensa, Hongo Henry, Abelson Sydney, Rivera Jose, Ngo Nhi, Herbst Dylan M, Suciu Radu M, Guijas Carlos, Sedighi Kimia, Andalis Taylor, Roche Elysia, Xie Boer, Liu Yunlong, Smith Catherine C, Stieglitz Elliot, Niphakis Micah J, Cravatt Benjamin F, Shannon Kevin
肿瘤
发表日期：2025
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ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity.

ABHD11抑制驱动甾醇代谢，从而调节T细胞效应功能并缓解自身免疫

期刊:
影响因子:
doi:10.1101/2025.03.19.643996
Jenkins Benjamin J, Jenkins Yasmin R, Ponce-Garcia Fernando M, Moscrop Chloe, Perry Iain A, Hitchings Matthew D, Uribe Alejandro H, Bernuzzi Federico, Eastham Simon, Cronin James G, Berisha Ardena, Howell Alexandra, Davies Joanne, Blagih Julianna, Veale Douglas J, Davies Luke C, Niphakis Micah, Finlay David K, Sinclair Linda V, Cravatt Benjamin F, Hogan Andrew E, Nathan James A, Fearon Ursula, Sumpton David, Vande Voorde Johan, Dias do Vale Goncalo, McDonald Jeffrey G, Jones Gareth W, Pearson James A, Vincent Emma E, Jones Nicholas
代谢
细胞生物学
T细胞
发表日期：2025
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Ligand discovery by activity-based protein profiling

基于活性蛋白质谱分析的配体发现

期刊:Cell Chemical Biology
影响因子:7.2
doi:10.1016/j.chembiol.2024.08.006
Niphakis, Micah J; Cravatt, Benjamin F
发表日期：2024
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Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB(1) receptor-mediated discriminative stimulus in mice

抑制内源性大麻素调节酶单酰甘油脂肪酶可诱导小鼠产生CB(1)受体介导的辨别性刺激。

期刊:Neuropharmacology
影响因子:4.6
doi:10.1016/j.neuropharm.2017.06.032
Owens, Robert A; Mustafa, Mohammed A; Ignatowska-Jankowska, Bogna M; Damaj, M Imad; Beardsley, Patrick M; Wiley, Jenny L; Niphakis, Micah J; Cravatt, Benjamin F; Lichtman, Aron H
信号转导
发表日期：2017
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Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure

二酰甘油脂肪酶在慢性尼古丁暴露期间会解除对腹侧被盖区（VTA）多巴胺神经元的抑制。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1522672113
Buczynski, Matthew W; Herman, Melissa A; Hsu, Ku-Lung; Natividad, Luis A; Irimia, Cristina; Polis, Ilham Y; Pugh, Holly; Chang, Jae Won; Niphakis, Micah J; Cravatt, Benjamin F; Roberto, Marisa; Parsons, Loren H
神经科学
发表日期：2016
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Facile synthesis of borofragments and their evaluation in activity-based protein profiling

硼片段的简易合成及其在基于活性的蛋白质谱分析中的评价

期刊:Chemical Communications
影响因子:4.2
doi:10.1039/c4cc09107h
Adachi, Shinya; Cognetta, Armand B 3rd; Niphakis, Micah J; He, Zhi; Zajdlik, Adam; St Denis, Jeffrey D; Scully, Conor C G; Cravatt, Benjamin F; Yudin, Andrei K
发表日期：2015
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Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells

绘制人类细胞中全功能化小分子探针的蛋白质相互作用图谱

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/ja505517t
Kambe, Tohru; Correia, Bruno E; Niphakis, Micah J; Cravatt, Benjamin F
细胞生物学
发表日期：2014
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Determining target engagement in living systems

确定生命系统中的目标参与情况

期刊:Nature Chemical Biology
影响因子:13.7
doi:10.1038/nchembio.1211
Simon, Gabriel M; Niphakis, Micah J; Cravatt, Benjamin F
发表日期：2013
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Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition

全蛋白质组反应性分析鉴定出多种针对丝氨酸水解酶抑制的氨基甲酸酯化学类型

期刊:ACS Chemical Biology
影响因子:3.8
doi:10.1021/cb400261h
Chang, Jae Won; Cognetta, Armand B 3rd; Niphakis, Micah J; Cravatt, Benjamin F
发表日期：2013
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Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)

脂蛋白相关磷脂酶A(2)的选择性抑制剂和定制活性探针

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2012.11.061
Nagano, Joseph M G; Hsu, Ku-Lung; Whitby, Landon R; Niphakis, Micah J; Speers, Anna E; Brown, Steven J; Spicer, Timothy; Fernandez-Vega, Virneliz; Ferguson, Jill; Hodder, Peter; Srinivasan, Prabhavathi; Gonzalez, Tara D; Rosen, Hugh; Bahnson, Brian J; Cravatt, Benjamin F
发表日期：2013
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