Nirinjini相关文献与解析，生知库 | 链接生命科学的每一步

Mutant mouse models implicate a role for mGluR1/5, prolyl isomerase (Pin1) and Homer1a interactions in wakefulness

突变小鼠模型表明，mGluR1/5、脯氨酰异构酶（Pin1）和Homer1a的相互作用在觉醒中发挥作用

doi:10.3389/fnins.2025.1572258

Keenan, Brendan T; Strus, Ewa; Lin, Raozhou; Chan, May; Lian, Jie; Galante, Raymond; Worley, Paul; Pack, Allan I; Naidoo, Nirinjini

发表日期：2025

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Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer's Disease mice

早期和晚期伴侣干预疗法可增强阿尔茨海默病小鼠的 XBP1s 和 ADAM10、恢复蛋白质稳态并挽救学习能力

期刊:

影响因子:

doi:10.1101/2023.05.23.541973

Jennifer M Hafycz, Ewa Strus, Nirinjini N Naidoo

Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer's Disease mice

早期和晚期分子伴侣干预疗法可提高 XBP1 和 ADAM10 的表达，恢复蛋白质稳态，并挽救阿尔茨海默病小鼠的学习能力。

期刊:

影响因子:

doi:10.59368/agingbio.20230017

Hafycz, Jennifer M; Strus, Ewa; Sengupta, Kamalini; Naidoo, Nirinjini N

Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

通过伴侣疗法减少内质网应激可逆转老年小鼠的睡眠碎片化和认知能力下降

期刊:Aging Cell

影响因子:8

doi:10.1111/acel.13598

Jennifer M Hafycz, Ewa Strus, Nirinjini Naidoo

信号转导

发表日期：2022

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Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome

Homer1a 调控 Shank3 的表达，并在 Phelan-McDermid 综合征模型中导致行为对压力的易感性。

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2021.110014

Lin, Raozhou; Learman, Lisa N; Bangash, M Ali; Melnikova, Tatiana; Leyder, Erica; Reddy, Sai C; Naidoo, Nirinjini; Park, Joo Min; Savonenko, Alena; Worley, Paul F

信号转导

发表日期：2021

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Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK

蛋白质翻译调节因子PERK对睡眠的进化保守调控

期刊:Current Biology

影响因子:7.5

doi:10.1016/j.cub.2020.02.030

Ly, Sarah; Lee, Daniel A; Strus, Ewa; Prober, David A; Naidoo, Nirinjini

Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila

DmGluRA 上 Homer 假定结合位点的基因破坏减少了果蝇的睡眠

期刊:Sleep

影响因子:5.3

doi:10.1093/sleep/zsz190

Sarah Ly, Ewa Strus, Nirinjini Naidoo

Drosophila

发表日期：2020

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Acute Sleep Loss Upregulates the Synaptic Scaffolding Protein, Homer1a, in Non-canonical Sleep/Wake Brain Regions, Claustrum, Piriform and Cingulate Cortices

急性睡眠不足上调非典型睡眠/觉醒脑区、隔膜、梨状皮质和扣带皮层中的突触支架蛋白 Homer1a

期刊:Frontiers in Neuroscience

影响因子:3.2

doi:10.3389/fnins.2020.00188

Jingxu Zhu, Jennifer Hafycz, Brendan T Keenan, Xiaofeng Guo, Allan Pack, Nirinjini Naidoo

信号转导

发表日期：2020

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The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms

瘦素增敏剂雷公藤内酯醇可减少与年龄相关的肥胖并调节行为节律。

期刊:Aging Cell

影响因子:7.1

doi:10.1111/acel.12874

Chellappa, Karthikeyani; Perron, Isaac J; Naidoo, Nirinjini; Baur, Joseph A

Chronic short sleep in early life accelerates cognitive decline via disrupted proteostasis

早期长期睡眠不足会通过扰乱蛋白质稳态加速认知衰退。

Mutant mouse models implicate a role for mGluR1/5, prolyl isomerase (Pin1) and Homer1a interactions in wakefulness

突变小鼠模型表明，mGluR1/5、脯氨酰异构酶（Pin1）和Homer1a的相互作用在觉醒中发挥作用

Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer's Disease mice

早期和晚期伴侣干预疗法可增强阿尔茨海默病小鼠的 XBP1s 和 ADAM10、恢复蛋白质稳态并挽救学习能力

Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer's Disease mice

早期和晚期分子伴侣干预疗法可提高 XBP1 和 ADAM10 的表达，恢复蛋白质稳态，并挽救阿尔茨海默病小鼠的学习能力。

Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

通过伴侣疗法减少内质网应激可逆转老年小鼠的睡眠碎片化和认知能力下降

Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome

Homer1a 调控 Shank3 的表达，并在 Phelan-McDermid 综合征模型中导致行为对压力的易感性。

Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK

蛋白质翻译调节因子PERK对睡眠的进化保守调控

Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila

DmGluRA 上 Homer 假定结合位点的基因破坏减少了果蝇的睡眠

Acute Sleep Loss Upregulates the Synaptic Scaffolding Protein, Homer1a, in Non-canonical Sleep/Wake Brain Regions, Claustrum, Piriform and Cingulate Cortices

急性睡眠不足上调非典型睡眠/觉醒脑区、隔膜、梨状皮质和扣带皮层中的突触支架蛋白 Homer1a

The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms

瘦素增敏剂雷公藤内酯醇可减少与年龄相关的肥胖并调节行为节律。