CDADC1 is a vertebrate-specific dCTP deaminase that metabolizes gemcitabine and decitabine to prevent cellular toxicity
CDADC1 是一种脊椎动物特异性的 dCTP 脱氨酶,可代谢吉西他滨和地西他滨,从而防止细胞毒性。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2424409122
Rodriguez, Marcelo M; Chatterjee, Debashree; Guerry, Johanna; Patenaude, Anne-Marie; Cohen, Charles C H; Bois, Therence; Larouche, Ariane; Ferreira, Silvana R; Bertomeu, Thierry; Chatr-Aryamontri, Andrew; Zhang, Li; Mader, Sylvie; Nislow, Corey; St-Jean, Guillaume; Guindon, Yvan; Zahn, Astrid; Di Noia, Javier M