日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Epigenetic priming promotes tyrosine kinase inhibitor resistance and oncogene amplification

表观遗传启动促进酪氨酸激酶抑制剂耐药性和癌基因扩增

Rebecca M Starble #,Eric G Sun #,Rana Gbyli,Jonathan Radda,Jiuwei Lu,Tyler B Jensen,Ning Sun,Nelli Khudaverdyan,Ting Zhao,Bomiao Hu,Mary Ann Melnick,Shuai Zhao,Nitin Roper,Gang Greg Wang,Alan J Tackett,Yinsheng Wang,Jikui Song,Katerina Politi,Siyuan Wang,Andrew Z Xiao

Identification of the Notch ligand DLK1 as an immunotherapeutic target and regulator of tumor cell plasticity and chemoresistance in adrenocortical carcinoma

鉴定出Notch配体DLK1是肾上腺皮质癌的免疫治疗靶点以及肿瘤细胞可塑性和化疗耐药性的调节因子

Nai-Yun Sun ,Suresh Kumar ,Yoo Sun Kim ,Diana Varghese ,Arnulfo Mendoza ,Rosa Nguyen ,Reona Okada ,Karlyne Reilly ,Brigitte Widemann ,Yves Pommier ,Fathi Elloumi ,Anjali Dhall ,Daiki Taniyama ,Mayank Patel ,Etan Aber ,Cristina F Contreras ,Rosandra N Kaplan ,Katja Kiseljak-Vassiliades ,Margaret E Wierman ,Dan Martinez ,Jennifer Pogoriler ,Amber K Hamilton ,Sharon J Diskin ,John M Maris ,Robert W Robey ,Michael M Gottesman ,Jaydira Del Rivero ,Nitin Roper

Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer

表观遗传启动促进人类肺癌中酪氨酸激酶抑制剂耐药性的获得和致癌基因的扩增

Rebecca M Starble, Eric G Sun, Rana Gbyli, Jonathan Radda, Jiuwei Lu, Tyler B Jensen, Ning Sun, Nelli Khudaverdyan, Bomiao Hu, Mary Ann Melnick, Shuai Zhao, Nitin Roper, Gang Greg Wang, Jikui Song, Katerina Politi, Siyuan Wang, Andrew Z Xiao

The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance

APOBEC3B在肺肿瘤演变和靶向癌症治疗耐药性中的作用

Deborah R Caswell #,Philippe Gui #,Manasi K Mayekar #,Emily K Law,Oriol Pich,Chris Bailey,Jesse Boumelha,D Lucas Kerr,Collin M Blakely,Tadashi Manabe,Carlos Martinez-Ruiz ,Bjorn Bakker,Juan De Dios Palomino Villcas,Natalie I Vokes ,Michelle Dietzen ,Mihaela Angelova,Beatrice Gini,Whitney Tamaki,Paul Allegakoen,Wei Wu,Timothy J Humpton ,William Hill,Mona Tomaschko,Wei-Ting Lu,Franziska Haderk,Maise Al Bakir,Ai Nagano,Francisco Gimeno-Valiente,Sophie de Carné Trécesson,Roberto Vendramin,Vittorio Barbè,Miriam Mugabo,Clare E Weeden,Andrew Rowan,Caroline E McCoach,Bruna Almeida ,Mary Green,Carlos Gomez,Shigeki Nanjo,Dora Barbosa,Chris Moore,Joanna Przewrocka,James R M Black ,Eva Grönroos,Alejandro Suarez-Bonnet ,Simon L Priestnall ,Caroline Zverev,Scott Lighterness,James Cormack,Victor Olivas,Lauren Cech,Trisha Andrews,Brandon Rule , Yuwei Jiao , Xinzhu Zhang , Paul Ashford , Cameron Durfee , Subramanian Venkatesan,Nuri Alpay Temiz  ,Lisa Tan,Lindsay K Larson,Prokopios P Argyris,William L Brown,Elizabeth A Yu  ,Julia K Rotow , Udayan Guha  ,Nitin Roper , Johnny Yu , Rachel I Vogel , Nicholas J Thomas,Antonio Marra , Pier Selenica , Helena Yu  ,Samuel F Bakhoum  ,Su Kit Chew,Jorge S Reis-Filho , Mariam Jamal-Hanjani,Karen H Vousden,Nicholas McGranahan ,Eliezer M Van Allen , Nnennaya Kanu,Reuben S Harris  ,Julian Downward,Trever G Bivona  ,Charles Swanton

Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells

Staufen1 通过破坏结直肠癌细胞中的 FOXA1 mRNA 来抑制 FOXA1 调控的转录组

Katherine R Pasterczyk, Xiao Ling Li, Ragini Singh, Meira S Zibitt, Corrine Corrina R Hartford, Lorinc Pongor, Lisa M Jenkins, Yue Hu, Patrick X Zhao, Bruna R Muys, Suresh Kumar, Nitin Roper, Mirit I Aladjem, Yves Pommier, Ioannis Grammatikakis, Ashish Lal

A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples

整合肾上腺皮质癌细胞系、PDX 和患者样本的基因组和药理学数据的数据库工具

Yasuhiro Arakawa, Fathi Elloumi, Sudhir Varma, Prashant Khandagale, Ukhyun Jo, Suresh Kumar, Nitin Roper, William C Reinhold, Robert W Robey, Naoko Takebe, Michael M Gottesman, Craig J Thomas, Valentina Boeva, Alfredo Berruti, Andrea Abate, Mariangela Tamburello, Sandra Sigala, Constanze Hantel, Isa

Activity of the Ubiquitin-activating Enzyme Inhibitor TAK-243 in Adrenocortical Carcinoma Cell Lines, Patient-derived Organoids, and Murine Xenografts

泛素活化酶抑制剂 TAK-243 在肾上腺皮质癌细胞系、患者来源的类器官和鼠异种移植中的活性

Yasuhiro Arakawa, Ukhyun Jo, Suresh Kumar, Nai-Yun Sun, Fathi Elloumi, Anish Thomas, Nitin Roper, Diana Grace Varghese, Naoko Takebe, Xiaohu Zhang, Michele Ceribelli, David O Holland, Erin Beck, Zina Itkin, Crystal McKnight, Kelli M Wilson, Jameson Travers, Carleen Klumpp-Thomas, Craig J Thomas, Chu

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

通过抑制 DCAF13-CRL4 泛素连接酶复合物,靶向 Neddylation 可使结直肠癌对拓扑异构酶 I 抑制剂敏感

Yilun Sun, Simone A Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M Factor, Yasuhiro Arakawa, Cindy H Chau, Kanako Okamoto, Anup Parikh, Bob Walker, Yijun P Su, Jiji Chen, Tabitha Ting, Shar-Yin N Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William

Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex

靶向NEDDylation可通过灭活DCAF13-CRL4泛素连接酶复合物,使结直肠癌细胞对拓扑异构酶I抑制剂更加敏感。

Yilun Sun,Simone A Baechler,Xiaohu Zhang,Suresh Kumar,Valentina M Factor,Yasuhiro Arakawa,Cindy H Chau,Kanako Okamoto,Anup Parikh,Bob Walker,Yijun P Su,Jiji Chen,Tabitha Ting,Shar-Yin N Huang,Erin Beck,Zina Itkin,Crystal McKnight,Changqing Xie,Nitin Roper,Deepak Nijhawan,William Douglas Figg,Paul S Meltzer,James C Yang,Craig J Thomas,Yves Pommier

Heterogeneity of neuroendocrine transcriptional states in metastatic small cell lung cancers and patient-derived models

转移性小细胞肺癌和患者衍生模型中神经内分泌转录状态的异质性

Delphine Lissa #, Nobuyuki Takahashi #, Parth Desai, Irena Manukyan, Christopher W Schultz, Vinodh Rajapakse, Moises J Velez, Deborah Mulford, Nitin Roper, Samantha Nichols, Rasa Vilimas, Linda Sciuto, Yuanbin Chen, Udayan Guha, Arun Rajan, Devon Atkinson, Rajaa El Meskini, Zoe Weaver Ohler, Anish T