日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1

在脯氨酸生物合成酶吡咯啉-5-羧酸还原酶1中意外发现变构抑制剂结合槽

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BCJ20250278
Meeks, Kaylen R; Mattingly, Caitlin J; Nix, Jay C; Chuk, Oleksii; Protopopov, Mykola V; Tarkhanova, Olga O; Tanner, John J
发表日期：2026
文献求助 收藏

Crystal structures reveal phosphorylation-dependent disruption of the heat shock protein 70-CHIP interface: A compensatory G132N variant restores binding affinity

晶体结构揭示了磷酸化依赖性的热休克蛋白70-CHIP界面破坏：补偿性G132N变体恢复了结合亲和力

期刊:Cell Stress & Chaperones
影响因子:3.2
doi:10.1016/j.cstres.2026.100166
Stewart, Mariah; Paththamperuma, Chathura; McCann, Colleen; Cottingim, Kelsey; Zhang, Huaqun; DelVecchio, Rian; Peng, Ivy; Fennimore, Erica; Nix, Jay C; Saeed, Morcos N; George, Kathleen; Makaroff, Katherine; Colie, Meagan; Paulakonis, Ethan; Almeida, Michael F; Afolayan, Adeleye J; Brown, Nicholas G; Page, Richard C; Schisler, Jonathan C
信号转导
磷酸化
CHIP
发表日期：2026
文献求助 收藏

Crystal structure of Methanococcus jannaschii dihydroorotase with substrate bound

詹氏甲烷球菌二氢乳清酸酶与底物结合的晶体结构

期刊:Acta Crystallographica Section F-Structural Biology Communications
影响因子:1.1
doi:10.1107/S2053230X25010556
Vitali, Jacqueline; Nix, Jay C; Newman, Haley E; Colaneri, Michael J
发表日期：2026
文献求助 收藏

Mutation of an active site-adjacent residue in VIM indirectly dictates interactions with and blunts inhibition by D-captopril

VIM 中活性位点邻近残基的突变间接决定了其与 D-卡托普利的相互作用并减弱了其抑制作用。

期刊:Journal of Inorganic Biochemistry
影响因子:3.2
doi:10.1016/j.jinorgbio.2025.112975
Silwal, Surendra Bikram; Wamsley, Bode; Wang, Zongyao; Gung, Benjamin W; Nix, Jay C; Page, Richard C
发表日期：2025
文献求助 收藏

Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase

对S-丁-3-炔-2-基甘氨酸作为黄素酶脯氨酸脱氢酶的机制性共价失活剂的生化、结构和细胞表征

期刊:Archives of Biochemistry and Biophysics
影响因子:3
doi:10.1016/j.abb.2025.110319
Meeks, Kaylen R; Ji, Juan; Scott, Gary K; Campbell, Ashley C; Nix, Jay C; Tadeo, Ada; Ellerby, Lisa M; Benz, Christopher C; Tanner, John J
细胞生物学
发表日期：2025
文献求助 收藏

ALS-ENABLE: creating synergy and opportunity at the Advanced Light Source synchrotron structural biology beamlines

ALS-ENABLE：在先进光源同步辐射结构生物学光束线上创造协同效应和机遇

期刊:Journal of Synchrotron Radiation
影响因子:3
doi:10.1107/S1600577525004205
Ralston, Corie Y; Gupta, Sayan; Del Mundo, Joshua T; Soe, Aimee Chi; Russell, Brandon; Rad, Behzad; Tyler, James; Paul, Sathi; Kahan, Darren N; Kristensen, Line G; Subramanian, Simruthi; Kidd, Savannah; Burnett, Kathryn; Sankaran, Banumathi; Classen, Scott; Prigozhin, Daniil M; Taylor, John R; Dickert, Jeff M; Royal, Kevin B; Rozales, Anthony; Ortega, Stacey L; Allaire, Marc; Nix, Jay C; Hura, Greg L; Holton, James M; Hammel, Michal; Adams, P D
ALS
发表日期：2025
文献求助 收藏

Functional and structural analyses of UbcH5 mutants with enhanced binding to the E3 ubiquitin ligase CHIP

对增强与 E3 泛素连接酶 CHIP 结合的 UbcH5 突变体进行功能和结构分析

期刊:Biochemical and Biophysical Research Communications
影响因子:2.2
doi:10.1016/j.bbrc.2025.152873
Manage, Maleesha M; Nix, Jay C; Page, Richard C
CHIP
发表日期：2025
文献求助 收藏

Phosphorylation-State Modulated Binding of HSP70: Structural Insights and Compensatory Protein Engineering

磷酸化状态调控HSP70的结合：结构解析和补偿性蛋白工程

期刊:
影响因子:
doi:10.1101/2025.02.17.637997
Stewart, Mariah; Paththamperuma, Chathura; McCann, Colleen; Cottingim, Kelsey; Zhang, Huaqun; DelVecchio, Rian; Peng, Ivy; Fennimore, Erica; Nix, Jay C; Saeed, Morcos N; George, Kathleen; Makaroff, Katherine; Colie, Meagan; Paulakonis, Ethan; Almeida, Michael F; Afolayan, Adeleye J; Brown, Nicholas G; Page, Richard C; Schisler, Jonathan C
信号转导
SP7
HSP70
磷酸化
发表日期：2025
文献求助 收藏

Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains

组合组蛋白修饰对ATAD2和ATAD2B溴结构域识别乙酰赖氨酸的影响

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.4c00210
Phillips, Margaret; Malone, Kiera L; Boyle, Brian W; Montgomery, Cameron; Kressy, Isabelle A; Joseph, Faith M; Bright, Kathleen M; Boyson, Samuel P; Chang, Sunsik; Nix, Jay C; Young, Nicolas L; Jeffers, Victoria; Frietze, Seth; Glass, Karen C
组蛋白修饰
表观遗传
发表日期：2024
文献求助 收藏

Crystallographic Fragment Screening of a Bifunctional Proline Catabolic Enzyme Reveals New Inhibitor Templates for Proline Dehydrogenase and L-Glutamate-γ-semialdehyde Dehydrogenase

双功能脯氨酸分解代谢酶的晶体学片段筛选揭示了脯氨酸脱氢酶和L-谷氨酸-γ-半醛脱氢酶的新抑制剂模板

期刊:Molecules
影响因子:4.6
doi:10.3390/molecules29225408
Meeks, Kaylen R; Bogner, Alexandra N; Nix, Jay C; Tanner, John J
代谢
发表日期：2024
文献求助 收藏