日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors

发现用于治疗实体肿瘤的 KRASG12C (AMG 510) 共价抑制剂

Brian A Lanman, Jennifer R Allen, John G Allen, Albert K Amegadzie, Kate S Ashton, Shon K Booker, Jian Jeffrey Chen, Ning Chen, Michael J Frohn, Guy Goodman, David J Kopecky, Longbin Liu, Patricia Lopez, Jonathan D Low, Vu Ma, Ana E Minatti, Thomas T Nguyen, Nobuko Nishimura, Alexander J Pickrell, A

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists

融合哌啶作为一类新型强效且可口服的瞬时受体电位黑素 8 型 (TRPM8) 拮抗剂

Nuria A Tamayo, Yunxin Bo, Vijay Gore, Vu Ma, Nobuko Nishimura, Phi Tang, Hong Deng, Lana Klionsky, Sonya G Lehto, Weiya Wang, Brad Youngblood, Jiyun Chen, Tiffany L Correll, Michael D Bartberger, Narender R Gavva, Mark H Norman