日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV‑2 Main Protease

单个卤素原子取代对靶向SARS-CoV-2主蛋白酶抑制剂抗病毒活性的影响

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.5c10895
Bulut, Haydar; Higashi-Kuwata, Nobuyo; Ogata-Aoki, Hiromi; Hayashi, Hironori; Takamune, Nobutoki; Kishimoto, Naoki; Das, Debananda; Li, Mi; Wlodawer, Alexander; Misumi, Shogo; Tamamura, Hirokazu; Mitsuya, Hiroaki
微生物学
SARS-CoV-2
发表日期：2026
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Targeting envelope lipids with 2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virus

利用2,6-二-O-甲基-3-乙酰基-β-环糊精靶向包膜脂质可削弱SARS-CoV-2和日本脑炎病毒的感染性

期刊:Journal of Virology
影响因子:3.8
doi:10.1128/jvi.01357-25
Kusakari, Daichi; Kishimoto, Naoki; Oshiro, Kazuyuki; Udeda, Yui; Takamune, Nobutoki; Motoyama, Keiichi; Misumi, Shogo
SARS-CoV-2
脑炎
炎症/感染
神经科学
微生物学
发表日期：2025
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An orally available P1'-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

口服 P1'-5-氟化 Mpro 抑制剂无需加强剂即可阻断 SARS-CoV-2 复制，且具有较高的遗传屏障

期刊:PNAS Nexus
影响因子:2.2
doi:10.1093/pnasnexus/pgae578
Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Maki Kiso, Nobutoki Takamune, Naoki Kishimoto, Shin-Ichiro Hattori, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Yukiko Shimizu, Debananda Das, Junji Saruwatari, Kazuya Hasegawa, Kazutaka Murayama, Yoshikazu S
免疫
新冠
Most
Goat
IgG F(ab')2
发表日期：2025
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Structural and virologic mechanism of the emergence of resistance to M(pro) inhibitors in SARS-CoV-2

SARS-CoV-2 对 M(pro) 抑制剂产生耐药性的结构和病毒学机制

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2404175121
Hattori, Shin-Ichiro; Bulut, Haydar; Hayashi, Hironori; Kishimoto, Naoki; Takamune, Nobutoki; Hasegawa, Kazuya; Furusawa, Yuri; Yamayoshi, Seiya; Murayama, Kazutaka; Tamamura, Hirokazu; Li, Mi; Wlodawer, Alexander; Kawaoka, Yoshihiro; Misumi, Shogo; Mitsuya, Hiroaki
微生物学
SARS-CoV-2
发表日期：2024
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Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

鉴定含有P1' 4-氟苯并噻唑基团的SARS-CoV-2 Mpro抑制剂，该抑制剂对SARS-CoV-2具有高度活性

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-023-36729-0
Nobuyo Higashi-Kuwata,Kohei Tsuji,Hironori Hayashi,Haydar Bulut,Maki Kiso,Masaki Imai,Hiromi Ogata-Aoki,Takahiro Ishii,Takuya Kobayakawa,Kenta Nakano,Nobutoki Takamune,Naoki Kishimoto,Shin-Ichiro Hattori,Debananda Das,Yukari Uemura,Yosuke Shimizu,Manabu Aoki,Kazuya Hasegawa,Satoshi Suzuki,Akie Nishiyama,Junji Saruwatari,Yukiko Shimizu,Yoshikazu Sukenaga,Yuki Takamatsu,Kiyoto Tsuchiya,Kenji Maeda,Kazuhisa Yoshimura,Shun Iida,Seiya Ozono,Tadaki Suzuki,Tadashi Okamura,Shogo Misumi,Yoshihiro Kawaoka,Hirokazu Tamamura,Hiroaki Mitsuya
新冠
SARS-CoV-2
发表日期：2023
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GRL-142 binds to and impairs HIV-1 integrase nuclear localization signal and potently suppresses highly INSTI-resistant HIV-1 variants

GRL-142 结合并损害 HIV-1 整合酶核定位信号，并有效抑制高度 INSTI 耐药的 HIV-1 变体

期刊:Science Advances
影响因子:11.7
doi:10.1126/sciadv.adg2955
Manabu Aoki, Hiromi Aoki-Ogata, Haydar Bulut, Hironori Hayashi, Nobutoki Takamune, Naoki Kishimoto, Hiroki Tanaka, Nobuyo Higashi-Kuwata, Shin-Ichiro Hattori, Debananda Das, Kalapala Venkateswara Rao, Kazuya Iwama, David A Davis, Kazuya Hasegawa, Kazutaka Murayama, Robert Yarchoan, Arun K Ghosh, Ali
信号转导
免疫
艾滋病
发表日期：2023
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Conversion of raltegravir carrying a 1,3,4-oxadiazole ring to a hydrolysis product upon pH changes decreases its antiviral activity

带有 1,3,4-恶二唑环的拉替拉韦在 pH 变化时转化为水解产物，从而降低其抗病毒活性

期刊:PNAS Nexus
影响因子:2.2
doi:10.1093/pnasnexus/pgad446
Tomofumi Nakamura, Mayu Okumura, Nobutoki Takamune, Tatsunori Hirotsu, Masaharu Sugiura, Junichiro Yasunaga, Hirotomo Nakata
免疫
微生物学
发表日期：2023
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Potent and biostable inhibitors of the main protease of SARS-CoV-2

SARS-CoV-2 主要蛋白酶的强效且生物稳定性抑制剂

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2022.105365
Kohei Tsuji ,Takahiro Ishii ,Takuya Kobayakawa ,Nobuyo Higashi-Kuwata ,Chika Azuma ,Miyuki Nakayama ,Takato Onishi ,Hiroki Nakano ,Naoya Wada ,Miki Hori ,Kouki Shinohara ,Yutaro Miura ,Takuma Kawada ,Hironori Hayashi ,Shin-Ichiro Hattori ,Haydar Bulut ,Debananda Das ,Nobutoki Takamune ,Naoki Kishimoto ,Junji Saruwatari ,Tadashi Okamura ,Kenta Nakano ,Shogo Misumi ,Hiroaki Mitsuya ,Hirokazu Tamamura
SARS-CoV-2
发表日期：2022
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Factors contributing to the swimmer puppy syndrome found in Labrador retrievers

导致拉布拉多寻回犬出现“游泳幼犬综合症”的因素

期刊:BMC Veterinary Research
影响因子:2.6
doi:10.1186/s12917-022-03226-3
Tomihari, Mizuki; Nobutoki, Yuko; Nakajima, Nagachika; Yanagawa, Masashi; Tagawa, Michihito; Hagiya, Koichi; Nomura, Tetsuro; Suwa, Yoshinori; Suzuki, Hiroshi
发表日期：2022
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Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV

鉴定出一种新型长效4'-修饰核苷类逆转录酶抑制剂，用于对抗乙型肝炎病毒

期刊:Journal of Hepatology
影响因子:33
doi:10.1016/j.jhep.2020.12.006
Higashi-Kuwata, Nobuyo; Hayashi, Sanae; Kumamoto, Hiroki; Ogata-Aoki, Hiromi; Das, Debananda; Venzon, David; Hattori, Shin-Ichiro; Bulut, Haydar; Hashimoto, Mai; Otagiri, Masaki; Takamune, Nobutoki; Kishimoto, Naoki; Davis, David A; Misumi, Shogo; Kakuni, Masakazu; Tanaka, Yasuhito; Mitsuya, Hiroaki
微生物学
肝炎
发表日期：2021
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