日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

First-in-Class Dual PDGFR/Carbonic Anhydrase IX/XII Inhibitors: 6,7-Dimethoxyquinoline-Sulfonamides as Promising Antileukemic Agents

首创的双重PDGFR/碳酸酐酶IX/XII抑制剂:6,7-二甲氧基喹啉磺酰胺类药物作为有前景的抗白血病药物

Roshdy, Eslam; Řezníčková, Eva; Elbadawi, Mostafa M; Celik, Ismail; Giovannuzzi, Simone; Veselá, Denisa; Vojáčková, Veronika; Krňávková, Petra; Nocentini, Alessio; Supuran, Claudiu T; Kryštof, Vladimír; Eldehna, Wagdy M; Abe, Manabu

Bacterial Carbonic Anhydrase Inhibitor CAI0019 Demonstrates Efficacy in Enterococcus faecium Septicemic Peritonitis Mouse Model While Sparing the Microbiome

细菌碳酸酐酶抑制剂 CAI0019 在粪肠球菌败血性腹膜炎小鼠模型中显示出疗效,同时不影响肠道菌群。

Abutaleb, Nader S; Holly, Katrina J; Metcalfe, Carolyn K; Abouelkhair, Ahmed A; Tharra, Prabhakara R; Shrinidhi, Annadka; Abdelsattar, Abdallah S; Burgo, Victoria; Melotte, Glory; Akin-Olabiyi, Tomi; Knoblauch, Sean; Ramaswamy, Ramanujam; Woodson, Che; Thirumalaikumar, Venkatesh P; Rodriguez, J Alejandra; Yeo, Franklin J; Snell, Olivia C; Nocentini, Alessio; Sundararajan, Anitha; Olson, Matthew R; Supuran, Claudiu T; Seleem, Mohamed N; Flaherty, Daniel P

Harnessing oligonucleotide architecture for potent multivalent inhibition of human carbonic anhydrases

利用寡核苷酸结构实现对人类碳酸酐酶的强效多价抑制

Abbass, Eslam M; Ladu, Federico; Mansot, Justine; Noël, Mathieu; Nocentini, Alessio; Sechi, Mario; Supuran, Claudiu T; Smietana, Michael; Winum, Jean-Yves

Benzoxaboroles Are Inhibitors of the η-Class Carbonic Anhydrase From Plasmodium falciparum

苯并硼氧杂环己烷是恶性疟原虫η类碳酸酐酶的抑制剂

Bonardi, Alessandro; Wein, Sharon; Mustafa, Muhamad; Cerdan, Rachel; de Luca, Viviana; Capasso, Clemente; Gratteri, Paola; Supuran, Claudiu T; Nocentini, Alessio; Winum, Jean-Yves

4-(5-Chloro-3-(3,4,5-trimethoxybenzoyl)-1H-indol-1-yl)benzenesulfonamide: A Novel Polypharmacology Agent to Target Carbonic Anhydrase IX and XII With Improved Selectivity, Wnt/β-Catenin Signaling Pathway, and P-Glycoprotein

4-(5-氯-3-(3,4,5-三甲氧基苯甲酰基)-1H-吲哚-1-基)苯磺酰胺:一种新型多靶点药物,可选择性地靶向碳酸酐酶IX和XII、Wnt/β-catenin信号通路以及P-糖蛋白。

Puxeddu, Michela; Bordone, Rosa; Colla, Claudia; Rotili, Gabriele; Coluccia, Antonio; Sciò, Pietro; Cuřínová, Petra; Nocentini, Alessio; Supuran, Claudiu T; Filiberti, Serena; Turati, Marta; Ronca, Roberto; Kopecka, Joanna; Riganti, Chiara; Jimenez, Lucia; Link, Wolfgang; Bigogno, Chiara; Dondio, Giulio; Barba, Martina; Canettieri, Gianluca; Silvestri, Romano; La Regina, Giuseppe

Intracellular Binding of Novel Fluorinated Compounds to Carbonic Anhydrase Isoforms Explored by In-Cell (19)F NMR

利用细胞内 (19)F NMR 研究新型氟化化合物与碳酸酐酶同工酶的细胞内结合

Costantino, Azzurra; Barbieri, Letizia; Giovannuzzi, Simone; Nocentini, Alessio; Supuran, Claudiu T; Raitelaitis, Mindaugas; Nordlund, Pär; Banci, Lucia; Luchinat, Enrico

Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia

基于乙酰唑胺的细菌碳酸酐酶抑制剂的先导化合物优化,以评估其在体内治疗耐万古霉素肠球菌败血症的疗效。

Holly, Katrina J; Tharra, Prabhakara R; Abutaleb, Nader S; Nocentini, Alessio; Abouelkhair, Ahmed A; Youse, Molly S; Marapaka, Anil Kumar; S Abdelsattar, Abdallah; An, Weiwei; Drummond, Faith L; Snell, Olivia C; Supuran, Claudiu T; Seleem, Mohamed N; Flaherty, Daniel P

Harnessing coumarin-thio(seleno)cyanate conjugates: potent In vivo antiproliferative agents targeting carbonic anhydrases

利用香豆素-硫代(硒代)氰酸酯缀合物:靶向碳酸酐酶的强效体内抗增殖剂

Meza-Ireta, Silvia Alejandra; Romero-Hernández, Laura L; Begines, Paloma; Giouvannuzi, Simone; Puerta, Adrián; González-Bakker, Aday; Romero-Franco, Amador; Huertas, Pablo; Nocentini, Alessio; Vega-Báez, José Luis; Montiel-Smith, Sara; Fernández-Bolaños, José G; Castellano-Pozo, Maikel; Padrón, José M; Supuran, Claudiu T; Merino-Montiel, Penélope; López, Óscar

Multifaceted Sulfonamide-Derived Thiosemicarbazones: Combining Metal Chelation and Carbonic Anhydrases Inhibition in Anticancer Therapy

多功能磺酰胺衍生的硫代氨基脲:结合金属螯合和碳酸酐酶抑制作用的抗癌治疗

Martínez-Montiel, Mónica; Arrighi, Giulia; Begines, Paloma; González-Bakker, Aday; Puerta, Adrián; Fernandes, Miguel X; Merino-Montiel, Penélope; Montiel-Smith, Sara; Nocentini, Alessio; Supuran, Claudiu T; Padrón, José M; Fernández-Bolaños, José G; López, Óscar

Targeting carbonic anhydrase IX/XII prevents the anti-ferroptotic effect of stromal lactic acid in prostate carcinoma.

靶向碳酸酐酶 IX/XII 可阻止基质乳酸在前列腺癌中的抗铁死亡作用

Pardella Elisa, Comito Giuseppina, Ippolito Luigi, Pranzini Erica, Iozzo Marta, Gangarossa Giulia, Virgilio Francesca, Bua Silvia, Nocentini Alessio, Sandrini Giada, Lorito Nicla, Bacci Marina, Nesi Gabriella, Spatafora Pietro, Serni Sergio, Supuran Claudiu T, Morandi Andrea, Chiarugi Paola, Giannoni Elisa