日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Model-Informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease

基于模型的深度Q网络指导儿童克罗恩病英夫利昔单抗给药

期刊:Clinical Pharmacology & Therapeutics
影响因子:5.5
doi:10.1002/cpt.70118
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2026
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Machine Learning Modeling for Predicting Infliximab Pharmacokinetics in Pediatric and Young Adult Patients With Crohn Disease: Leveraging Ensemble Modeling With Synthetic and Real-World Data

利用机器学习模型预测英夫利昔单抗在克罗恩病患儿及青少年患者中的药代动力学：结合合成数据和真实世界数据的集成建模

期刊:Therapeutic Drug Monitoring
影响因子:2.4
doi:10.1097/FTD.0000000000001348
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2026
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Hybrid Population Pharmacokinetic-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

采用混合群体药代动力学-机器学习模型预测克罗恩病患儿及青少年患者的英夫利昔单抗药代动力学

期刊:Clinical Pharmacokinetics
影响因子:4
doi:10.1007/s40262-025-01564-7
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2025
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Hybrid Population PK-Machine Learning Modeling to Predict Infliximab Pharmacokinetics in Pediatric and Young Adult Patients with Crohn's Disease

采用混合群体药代动力学-机器学习模型预测克罗恩病患儿及青少年患者的英夫利昔单抗药代动力学

期刊:
影响因子:
doi:10.1101/2025.05.01.651780
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, Jeffrey S; Mizuno, Tomoyuki
克罗恩病
发表日期：2025
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Model-informed Deep Q-Networks to Guide Infliximab Dosing in Pediatric Crohn's Disease

基于模型的深度Q网络指导儿童克罗恩病英夫利昔单抗给药

期刊:
影响因子:
doi:10.1101/2025.07.14.664804
Irie, Kei; Minar, Phillip; Reifenberg, Jack; Boyle, Brendan M; Noe, Joshua D; Hyams, S Jeffrey; Mizuno, Tomoyuki
克罗恩病
发表日期：2025
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Progression of Pediatric Crohn's Disease Is Associated With Anti-Tumor Necrosis Factor Timing and Body Mass Index Z-Score Normalization

儿童克罗恩病进展与抗肿瘤坏死因子治疗时机和体重指数Z评分正常化相关

期刊:Clinical Gastroenterology and Hepatology
影响因子:12
doi:10.1016/j.cgh.2023.08.042
Geem, Duke; Hercules, David; Pelia, Ranjit S; Venkateswaran, Suresh; Griffiths, Anne; Noe, Joshua D; Dotson, Jennifer L; Snapper, Scott; Rabizadeh, Shervin; Rosh, Joel R; Baldassano, Robert N; Markowitz, James F; Walters, Thomas D; Ananthakrishnan, Ashwin; Sharma, Garima; Denson, Lee A; Hyams, Jeffrey S; Kugathasan, Subra
肿瘤
克罗恩病
肿瘤免疫
发表日期：2024
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Real world population pharmacokinetic study in children and young adults with inflammatory bowel disease discovers novel blood and stool microbial predictors of vedolizumab clearance

一项针对患有炎症性肠病的儿童和青少年的真实世界人群药代动力学研究发现了维多珠单抗清除率的新型血液和粪便微生物预测因子。

期刊:Alimentary Pharmacology & Therapeutics
影响因子:6.7
doi:10.1111/apt.17277
Colman, Ruben J; Mizuno, Tomoyuki; Fukushima, Keizo; Haslam, David B; Hyams, Jeffrey S; Boyle, Brendan; Noe, Joshua D; D'Haens, Geert R; Van Limbergen, Johan; Chun, Kelly; Yang, Jane; Denson, Lee A; Ollberding, Nicholas J; Vinks, Alexander A; Minar, Phillip
炎症/感染
炎症
微生物学
发表日期：2023
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Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Stricturing Complications in Pediatric Crohn's Disease

血清纤维化蛋白生物标志物有助于对儿童克罗恩病未来发生狭窄性并发症进行风险分层

期刊:American Journal of Gastroenterology
影响因子:7.6
doi:10.14309/ajg.0000000000000237
Wu, Jing; Lubman, David M; Kugathasan, Subra; Denson, Lee A; Hyams, Jeffrey S; Dubinsky, Marla C; Griffiths, Anne M; Baldassano, Robert N; Noe, Joshua D; Rabizadeh, Shervin; Gulati, Ajay S; Rosh, Joel R; Crandall, Wallace V; Higgins, Peter D R; Stidham, Ryan W
克罗恩病
发表日期：2019
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Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort

儿童炎症性肠病队列中涉及的遗传变异和通路

期刊:Genes and Immunity
影响因子:4.5
doi:10.1038/s41435-018-0015-2
Shaw, Kelly A; Cutler, David J; Okou, David; Dodd, Anne; Aronow, Bruce J; Haberman, Yael; Stevens, Christine; Walters, Thomas D; Griffiths, Anne; Baldassano, Robert N; Noe, Joshua D; Hyams, Jeffrey S; Crandall, Wallace V; Kirschner, Barbara S; Heyman, Melvin B; Snapper, Scott; Guthery, Stephen; Dubinsky, Marla C; Shapiro, Jason M; Otley, Anthony R; Daly, Mark; Denson, Lee A; Kugathasan, Subra; Zwick, Michael E
信号转导
炎症/感染
炎症
发表日期：2019
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Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease

儿童克罗恩病中与中性粒细胞-巨噬细胞集落刺激因子信号传导相关的遗传和转录组变异

期刊:Inflammatory Bowel Diseases
影响因子:4.3
doi:10.1093/ibd/izy265
Denson, Lee A; Jurickova, Ingrid; Karns, Rebekah; Shaw, Kelly A; Cutler, David J; Okou, David; Valencia, C Alexander; Dodd, Anne; Mondal, Kajari; Aronow, Bruce J; Haberman, Yael; Linn, Aaron; Price, Adam; Bezold, Ramona; Lake, Kathleen; Jackson, Kimberly; Walters, Thomas D; Griffiths, Anne; Baldassano, Robert N; Noe, Joshua D; Hyams, Jeffrey S; Crandall, Wallace V; Kirschner, Barbara S; Heyman, Melvin B; Snapper, Scott; Guthery, Stephen L; Dubinsky, Marla C; Leleiko, Neal S; Otley, Anthony R; Xavier, Ramnik J; Stevens, Christine; Daly, Mark J; Zwick, Michael E; Kugathasan, Subra
信号转导
粒细胞
克罗恩病
免疫/内分泌
巨噬细胞
细胞生物学
中性粒细胞
巨噬细胞
发表日期：2019
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