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Benzoxazole Derivatives as Potent FXR and PPARα Dual Agonists With Anti-Fibrotic and Metabolic Regulatory Effects

苯并恶唑衍生物作为强效FXR和PPARα双重激动剂，具有抗纤维化和代谢调节作用

Kim, Mi-Jeong; Han, Dong-Gyun; Park, Hyeon Seo; Ha, Sugyeong; Noh, Sang Gyun; Kim, Jeongwon; Yoo, Ji-An; Kim, Byeong Moo; Battogtokh, Khas-Erdene; Oh, Soohwan; Jung, Youngmi; Jung, Youngsuk; Chung, Hae Young; Moon, Hyung Ryong; Yoon, In-Soo; Chung, Ki Wung

代谢

发表日期：2025

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Design and Synthesis of Novel 6-(Substituted phenyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]thiazole Compounds as Tyrosinase Inhibitors: In Vitro and In Vivo Insights.

新型 6-(取代苯基)-[1,3]二氧杂环戊烯并[4',5':4,5]苯并[1,2-d]噻唑化合物作为酪氨酸酶抑制剂的设计与合成：体外和体内研究

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules30071535

Park Hyeon Seo, Jung Hee Jin, Park Hye Soo, Kim Hye Jin, Noh Sang Gyun, Park Yujin, Chun Pusoon, Chung Hae Young, Moon Hyung Ryong

信号转导

发表日期：2025

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Co-regulation of Nr1d1 and PparÎ± in age-related changes of lipid metabolism and its modulation by calorie restriction.

Nr1d1 和 PparÎ± 在与年龄相关的脂质代谢变化中的协同调节及其受热量限制的调节

期刊:Aging-Us

影响因子:3.9

doi:10.18632/aging.206289

Noh Sang Gyun, Kim Hyun Woo, Kim Seungwoo, Yu Byung Pal, Yoon Jeong-Hyun, Chung Ki Wung, Lee Jaewon, Chung Hae Young

代谢

发表日期：2025

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8-Prenylgenistein Isoflavone in Cheonggukjang Acts as a Novel AMPK Activator Attenuating Hepatic Steatosis by Enhancing the SIRT1-Mediated Pathway

清麴酱中的8-异戊烯基染料木素异黄酮作为一种新型AMPK激活剂，通过增强SIRT1介导的通路来减轻肝脂肪变性。

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms25179730

Arulkumar, Radha; Jung, Hee Jin; Noh, Sang Gyun; Kim, Hyun Woo; Chung, Hae Young

Identification of Bioactive Compounds from the Roots of Rehmannia glutinosa and Their In Silico and In Vitro AMPK Activation Potential.

从地黄根中鉴定生物活性化合物及其计算机模拟和体外 AMPK 激活潜力

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules29246009

Lee Hwaryeong, Youn Isoo, Noh Sang Gyun, Kim Hyun Woo, Song Eunhye, Nam Sang-Jip, Chung Hae Young, Seo Eun Kyoung

FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet

FoxO6介导的ApoC3上调促进高脂饮食喂养的老年大鼠发生肝脂肪变性和高脂血症

期刊:Aging-Us

影响因子:3.9

doi:10.18632/aging.205610

Kim, Dae Hyun; Lee, Seulah; Noh, Sang Gyun; Lee, Jaewon; Chung, Hae Young

Rat

发表日期：2024

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Anti-Inflammatory Activity of the Constituents from the Leaves of Perilla frutescens var. acuta

紫苏叶成分的抗炎活性

期刊:Pharmaceuticals

影响因子:4.8

doi:10.3390/ph16121655

Youn, Isoo; Han, Sujin; Jung, Hee Jin; Noh, Sang Gyun; Chung, Hae Young; Koo, Yean Kyoung; Shin, Sunhye; Seo, Eun Kyoung

发表日期：2023

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Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5H)-one Derivatives: A Novel Class of Anti-Melanogenic Compounds

5-(取代亚苄基)-2-苯基噻唑-4(5H)-酮衍生物的设计、合成、体外和计算机模拟研究：一类新型抗黑色素生成化合物

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules28083293

Yoon, Dahye; Kang, Min Kyung; Jung, Hee Jin; Ullah, Sultan; Lee, Jieun; Jeong, Yeongmu; Noh, Sang Gyun; Kang, Dongwan; Park, Yujin; Chun, Pusoon; Chung, Hae Young; Moon, Hyung Ryong

发表日期：2023

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Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity

草果酸：一种从草果中分离得到的具有乙酰胆碱酯酶抑制活性的新型双环壬烯类化合物

期刊:Molecules

影响因子:4.6

doi:10.3390/molecules28062602

Kim, Hyunyoung; Lee, Hwaryeong; Jung, Hee Jin; Noh, Sang Gyun; Youn, Isoo; Kwak, Hyunkyung; Lee, Yeju; Nam, Sang-Jip; Kang, Soosung; Chung, Hae Young; Seo, Eun Kyoung

发表日期：2023

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Calorie Restriction Modulates Gene Expression of Il19 and Il24 during Renal Aging

热量限制调节肾脏衰老过程中IL-19和IL-24的基因表达

Benzoxazole Derivatives as Potent FXR and PPARα Dual Agonists With Anti-Fibrotic and Metabolic Regulatory Effects

苯并恶唑衍生物作为强效FXR和PPARα双重激动剂，具有抗纤维化和代谢调节作用

Design and Synthesis of Novel 6-(Substituted phenyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]thiazole Compounds as Tyrosinase Inhibitors: In Vitro and In Vivo Insights.

新型 6-(取代苯基)-[1,3]二氧杂环戊烯并[4',5':4,5]苯并[1,2-d]噻唑化合物作为酪氨酸酶抑制剂的设计与合成：体外和体内研究

Co-regulation of Nr1d1 and PparÎ± in age-related changes of lipid metabolism and its modulation by calorie restriction.

Nr1d1 和 PparÎ± 在与年龄相关的脂质代谢变化中的协同调节及其受热量限制的调节

8-Prenylgenistein Isoflavone in Cheonggukjang Acts as a Novel AMPK Activator Attenuating Hepatic Steatosis by Enhancing the SIRT1-Mediated Pathway

清麴酱中的8-异戊烯基染料木素异黄酮作为一种新型AMPK激活剂，通过增强SIRT1介导的通路来减轻肝脂肪变性。

Identification of Bioactive Compounds from the Roots of Rehmannia glutinosa and Their In Silico and In Vitro AMPK Activation Potential.

从地黄根中鉴定生物活性化合物及其计算机模拟和体外 AMPK 激活潜力

FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet

FoxO6介导的ApoC3上调促进高脂饮食喂养的老年大鼠发生肝脂肪变性和高脂血症

Anti-Inflammatory Activity of the Constituents from the Leaves of Perilla frutescens var. acuta

紫苏叶成分的抗炎活性

Design, Synthesis, In Vitro, and In Silico Insights of 5-(Substituted benzylidene)-2-phenylthiazol-4(5H)-one Derivatives: A Novel Class of Anti-Melanogenic Compounds

5-(取代亚苄基)-2-苯基噻唑-4(5H)-酮衍生物的设计、合成、体外和计算机模拟研究：一类新型抗黑色素生成化合物

Tsaokoic Acid: A New Bicyclic Nonene from the Fruits of Amomum tsao-ko with Acetylcholinesterase Inhibitory Activity

草果酸：一种从草果中分离得到的具有乙酰胆碱酯酶抑制活性的新型双环壬烯类化合物