日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Highly conserved brain vascular receptor ALPL mediates transport of engineered AAV vectors across the blood-brain barrier.

高度保守的脑血管受体ALPL介导工程化AAV载体跨越血脑屏障的运输。

Moyer Tyler C, Hoffman Brett A, Chen Weitong, Shah Ishan, Ren Xiao-Qin, Knox Tatiana, Liu Jiachen, Wang Wei, Li Jiangyu, Khalid Hamza, Kulkarni Anupriya S, Egbuchulam Munachiso, Clement Joseph, Bloedel Alexis, Child Matthew, Kaur Rupinderjit, Rouse Emily, Graham Kristin, Maura Damien, Thorpe Zachary, Sayed-Zahid Ambreen, Hiu-Yan Chung Charlotte, Kutchin Alexander, Johnson Amy, Yao Johnny, Thompson Jeffrey, Pande Nilesh, Nonnenmacher Mathieu E

Every little bit helps: A single-residue switch in a vascular AAV enables blood-brain barrier penetration

积少成多:血管型腺相关病毒(AAV)中单个残基的改变即可使其穿透血脑屏障。

Grimm, Dirk; Nonnenmacher, Mathieu

Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact

基因编辑逆转人源化PLN-R14del小鼠的心律失常易感性:模拟一种具有全球影响的欧洲心肌病

Dave, Jaydev; Raad, Nour; Mittal, Nishka; Zhang, Lu; Fargnoli, Anthony; Oh, Jae Gyun; Savoia, Maria Elisabetta; Hansen, Jens; Fava, Marika; Yin, Xiaoke; Theofilatos, Konstantinos; Ceholski, Delaine; Kohlbrenner, Erik; Jeong, Dongtak; Wills, Lauren; Nonnenmacher, Mathieu; Haghighi, Kobra; Costa, Kevin D; Turnbull, Irene C; Mayr, Manuel; Cai, Chen-Leng; Kranias, Evangelia G; Akar, Fadi G; Hajjar, Roger J; Stillitano, Francesca

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

利用人诱导多能干细胞衍生的心肌细胞,从功能和转录组学角度深入了解R9C磷蛋白突变的发病机制

Ceholski, Delaine K; Turnbull, Irene C; Kong, Chi-Wing; Koplev, Simon; Mayourian, Joshua; Gorski, Przemek A; Stillitano, Francesca; Skodras, Angelos A; Nonnenmacher, Mathieu; Cohen, Ninette; Björkegren, Johan L M; Stroik, Daniel R; Cornea, Razvan L; Thomas, David D; Li, Ronald A; Costa, Kevin D; Hajjar, Roger J

High capsid-genome correlation facilitates creation of AAV libraries for directed evolution

衣壳-基因组高度相关性有利于构建用于定向进化的AAV文库。

Nonnenmacher, Mathieu; van Bakel, Harm; Hajjar, Roger J; Weber, Thomas

High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy.

高剂量氯喹通过诱导压力超负荷肥大大鼠模型中的溶酶体和线粒体功能障碍,具有代谢性心脏毒性

Chaanine Antoine H, Gordon Ronald E, Nonnenmacher Mathieu, Kohlbrenner Erik, Benard Ludovic, Hajjar Roger J

Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure

硼替佐米对AAV9.SERCA2a治疗在压力负荷过重的大鼠心力衰竭模型中保护心脏功能的疗效的影响

Chaanine, Antoine H; Nonnenmacher, Mathieu; Kohlbrenner, Erik; Jin, Dongzhu; Kovacic, Jason C; Akar, Fadi G; Hajjar, Roger J; Weber, Thomas

Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway

腺相关病毒2型感染需要通过CLIC/GEEC途径进行内吞作用。

Nonnenmacher, Mathieu; Weber, Thomas

Effect of inhibition of dynein function and microtubule-altering drugs on AAV2 transduction

抑制动力蛋白功能和微管改变药物对AAV2转导的影响

Hirosue, Sachiko; Senn, Karin; Clément, Nathalie; Nonnenmacher, Mathieu; Gigout, Laure; Linden, R Michael; Weber, Thomas

Cottontail rabbit papillomavirus E8 protein is essential for wart formation and provides new insights into viral pathogenesis

棉尾兔乳头瘤病毒E8蛋白对疣的形成至关重要,并为病毒致病机制提供了新的见解。

Nonnenmacher, Mathieu; Salmon, Jérôme; Jacob, Yves; Orth, Gérard; Breitburd, Françoise