日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

cGAS inhibition delays TDP-43-driven ALS Pathogenesis

cGAS抑制可延缓TDP-43驱动的ALS发病机制

Liu, Yajing; Feng, Weixi; Aikedan, Abulimiti; Lee, Se-In; Bhagwat, Maitreyee; Nagiri, Ravi Kumar; Wong, Man Ying; Amin, Sadaf; Qu, Wenhui; Zhu, Jingjie; Wang, Si-Yu; Ye, Pearly; Norman, Kendra; Coronas-Samano, Guillermo; Olah, Marta; Tilgner, Hagen U; Fan, Li; Sinha, Subhash C; Gan, Li

cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy.

cGAS介导的I型干扰素信号传导促进药物难治性癫痫的疾病进展。

Huang Yige, Fan Li, Wong Man Ying, Lei Zhuofan, Krishnamachary Balaji, Zhu Daphne, Cadiz Mika, Nagiri Ravi Kumar, Ye Pearly, Norman Kendra, Bhagwat Maitreyee, Lee Young Jae, Li Hui, Zhu Jingjie, Amin Sadaf, Lauderdale Kelli, Chen Hao, Luo Wenjie, Gong Shiaoching, Liechty Benjamin L, Palop Jorge J, Sinha Subhash C, Wu Junfang, Zhao Mingrui, Gan Li

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.

APOE3 基因中的 R136S 突变通过抑制 cGAS-STING-IFN 通路赋予机体抵抗 tau 病理的能力

Naguib Sarah, Lopez-Lee Chloe, Torres Eileen Ruth, Lee Se-In, Zhu Jingjie, Zhu Daphne, Ye Pearly, Norman Kendra, Zhao Mingrui, Wong Man Ying, Ambaw Yohannes A, Muñoz-Castañeda Rodrigo, Wang Wei, Patel Tark, Bhagwat Maitreyee, Norinsky Rada, Mok Sue-Ann, Walther Tobias C, Farese Robert V Jr, Luo Wenjie, Sinha Subhash C, Wu Zhuhao, Fan Li, Gong Shiaoching, Gan Li

STING-IFN-CH25H lipid axis links innate immune activation to tau pathology

STING-IFN-CH25H脂质轴将先天免疫激活与tau蛋白病理联系起来

Chen, Hao; Fan, Li; Wong, Man Ying; Ambaw, Yohannes A; Zhu, Jingjie; Norman, Kendra; Ye, Pearly; Foxe, Nessa; Zhu, Daphne; Wan, Yuansong; Srinivasan, Mahalashmi; Mok, Sue-Ann; McIntire, Laura Beth J; Walther, Tobias C; Farese, Robert V; Gan, Li; Luo, Wenjie

Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.

Tlr7 驱动与年龄和阿尔茨海默病相关的脱髓鞘的性别差异

Lopez-Lee Chloe, Kodama Lay, Fan Li, Zhu Daphne, Zhu Jingjie, Wong Man Ying, Ye Pearly, Norman Kendra, Foxe Nessa R, Ijaz Laraib, Yu Fangmin, Chen Hao, Carling Gillian K, Torres Eileen R, Kim Rachel D, Dubal Dena B, Liddelow Shane A, Sinha Subhash C, Luo Wenjie, Gan Li

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

阿尔茨海默病相关风险等位基因在 tau 蛋白病模型中加剧小胶质细胞 cGAS 相关的衰老和神经退行性变

Carling Gillian K, Fan Li, Foxe Nessa R, Norman Kendra, Wong Man Ying, Zhu Daphne, Corona Carlo, Razzoli Agnese, Yu Fangmin, Yarahmady Allan, Ye Pearly, Chen Hao, Huang Yige, Amin Sadaf, Sereda Rebecca, Lopez-Lee Chloe, Zacharioudakis Emmanouil, Chen Xiaoying, Xu Jielin, Cheng Feixiong, Gavathiotis Evripidis, Cuervo Ana Maria, Holtzman David M, Mok Sue-Ann, Sinha Subhash C, Sidoli Simone, Ratan Rajiv R, Luo Wenjie, Gong Shiaoching, Gan Li