日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Computational design of serine hydrolases

丝氨酸水解酶的计算设计

Lauko, Anna; Pellock, Samuel J; Sumida, Kiera H; Anishchenko, Ivan; Juergens, David; Ahern, Woody; Jeung, Jihun; Shida, Alexander F; Hunt, Andrew; Kalvet, Indrek; Norn, Christoffer; Humphreys, Ian R; Jamieson, Cooper; Krishna, Rohith; Kipnis, Yakov; Kang, Alex; Brackenbrough, Evans; Bera, Asim K; Sankaran, Banumathi; Houk, K N; Baker, David

Computational design of sequence-specific DNA-binding proteins

序列特异性DNA结合蛋白的计算设计

Glasscock, Cameron J; Pecoraro, Robert J; McHugh, Ryan; Doyle, Lindsey A; Chen, Wei; Boivin, Olivier; Lonnquist, Beau; Na, Emily; Politanska, Yuliya; Haddox, Hugh K; Cox, David; Norn, Christoffer; Coventry, Brian; Goreshnik, Inna; Vafeados, Dionne; Lee, Gyu Rie; Gordân, Raluca; Stoddard, Barry L; DiMaio, Frank; Baker, David

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors.

从头设计靶向 G 蛋白偶联受体的微型蛋白激动剂和拮抗剂

Muratspahić Edin, Feldman David, Kim David E, Qu Xiangli, Bratovianu Ana-Maria, Rivera-Sánchez Paula, Dimitri Federica, Cao Jason, Cary Brian P, Belousoff Matthew J, Keov Peter, Chen Qingchao, Ren Yue, Fine Justyn, Sappington Isaac, Schlichthaerle Thomas, Zhang Jason Z, Pillai Arvind, Mihaljević Ljubica, Bauer Magnus, Torres Susana Vázquez, Motmaen Amir, Lee Gyu Rie, Tran Long, Wang Xinru, Goreshnik Inna, Vafeados Dionne K, Svendsen Justin E, Hosseinzadeh Parisa, Lindegaard Nicolai, Brandt Matthäus, Waltenspühl Yann, Deibler Kristine, Oostdyk Luke, Cao William, Anantharaman Lakshmi, Stewart Lance, Halloran Lauren, Spangler Jamie B, Sexton Patrick M, Roth Bryan L, Krumm Brian E, Wootten Denise, Tate Christopher G, Norn Christoffer, Baker David

Binding and sensing diverse small molecules using shape-complementary pseudocycles

利用形状互补的伪环结合和检测多种小分子

An, Linna; Said, Meerit; Tran, Long; Majumder, Sagardip; Goreshnik, Inna; Lee, Gyu Rie; Juergens, David; Dauparas, Justas; Anishchenko, Ivan; Coventry, Brian; Bera, Asim K; Kang, Alex; Levine, Paul M; Alvarez, Valentina; Pillai, Arvind; Norn, Christoffer; Feldman, David; Zorine, Dmitri; Hicks, Derrick R; Li, Xinting; Sanchez, Mariana Garcia; Vafeados, Dionne K; Salveson, Patrick J; Vorobieva, Anastassia A; Baker, David

Improved prediction of site-rates from structure with averaging across homologs

通过对同源序列进行平均,改进从结构预测位点速率的方法

Norn, Christoffer; Oliveira, Fábio; André, Ingemar

De novo design of luciferases using deep learning

利用深度学习从头设计荧光素酶

Yeh, Andy Hsien-Wei; Norn, Christoffer; Kipnis, Yakov; Tischer, Doug; Pellock, Samuel J; Evans, Declan; Ma, Pengchen; Lee, Gyu Rie; Zhang, Jason Z; Anishchenko, Ivan; Coventry, Brian; Cao, Longxing; Dauparas, Justas; Halabiya, Samer; DeWitt, Michelle; Carter, Lauren; Houk, K N; Baker, David

Atomistic simulation of protein evolution reveals sequence covariation and time-dependent fluctuations of site-specific substitution rates

蛋白质进化的原子级模拟揭示了序列共变和位点特异性替换率随时间变化的波动。

Norn, Christoffer; André, Ingemar

Small-molecule binding and sensing with a designed protein family

利用设计的蛋白质家族进行小分子结合和传感

Lee, Gyu Rie; Pellock, Samuel J; Norn, Christoffer; Tischer, Doug; Dauparas, Justas; Anischenko, Ivan; Mercer, Jaron A M; Kang, Alex; Bera, Asim; Nguyen, Hannah; Goreshnik, Inna; Vafeados, Dionne; Roullier, Nicole; Han, Hannah L; Coventry, Brian; Haddox, Hugh K; Liu, David R; Yeh, Andy Hsien-Wei; Baker, David

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles

利用形状互补伪环从头设计多种小分子结合剂和传感器

An, Linna; Said, Meerit; Tran, Long; Majumder, Sagardip; Goreshnik, Inna; Lee, Gyu Rie; Juergens, David; Dauparas, Justas; Anishchenko, Ivan; Coventry, Brian; Bera, Asim K; Kang, Alex; Levine, Paul M; Alvarez, Valentina; Pillai, Arvind; Norn, Christoffer; Feldman, David; Zorine, Dmitri; Hicks, Derrick R; Li, Xinting; Sanchez, Mariana Garcia; Vafeados, Dionne K; Salveson, Patrick J; Vorobieva, Anastassia A; Baker, David

De novo protein design by deep network hallucination

利用深度网络幻觉进行从头蛋白质设计

Anishchenko, Ivan; Pellock, Samuel J; Chidyausiku, Tamuka M; Ramelot, Theresa A; Ovchinnikov, Sergey; Hao, Jingzhou; Bafna, Khushboo; Norn, Christoffer; Kang, Alex; Bera, Asim K; DiMaio, Frank; Carter, Lauren; Chow, Cameron M; Montelione, Gaetano T; Baker, David