日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ectopic, hepatic GLP-1R agonism enhances the weight loss efficacy of GLP-1 analogues

异位肝脏GLP-1R激动作用可增强GLP-1类似物的减肥效果。

Douros, Jonathan D; Capozzi, Megan; Novikoff, Aaron; Mokrosinski, Jacek; DuBois, Barent; Stock, Joseph; Rohlfs, Rebecca; Anderson, Mikayla; Jedrzejcyk, Dominika J; Poulsen, Svend; Blenke, Erik Oude; Dago, Tomas; Huus, Kasper; Nørby, Peder L; Kobberup, Sune; Rivir, Marita; Sorrell, Joyce; Mowery, Stephanie A; Drucker, Daniel J; D'Alessio, David A; Campbell, Jonathan E; Müller, Timo D; Perez-Tilve, Diego; Finan, Brian; Knerr, Patrick J

Publisher Correction: GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice

出版商更正:GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量。

Gutgesell, Robert M; Khalil, Ahmed; Liskiewicz, Arkadiusz; Maity-Kumar, Gandhari; Novikoff, Aaron; Grandl, Gerald; Liskiewicz, Daniela; Coupland, Callum; Karaoglu, Ezgi; Akindehin, Seun; Castelino, Russell; Curion, Fabiola; Liu, Xue; Garcia-Caceres, Cristina; Cebrian-Serrano, Alberto; Douros, Jonathan D; Knerr, Patrick J; Finan, Brian; DiMarchi, Richard D; Sloop, Kyle W; Samms, Ricardo J; Theis, Fabian J; Tschöp, Matthias H; Müller, Timo D

GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice.

GIPR激动剂和拮抗剂通过不同的机制降低雄性小鼠的体重和食物摄入量

Gutgesell Robert M, Khalil Ahmed, Liskiewicz Arkadiusz, Maity-Kumar Gandhari, Novikoff Aaron, Grandl Gerald, Liskiewicz Daniela, Coupland Callum, Karaoglu Ezgi, Akindehin Seun, Castelino Russell, Curion Fabiola, Liu Xue, Garcia-Caceres Cristina, Cebrian-Serrano Alberto, Douros Jonathan D, Knerr Patrick J, Finan Brian, DiMarchi Richard D, Sloop Kyle W, Samms Ricardo J, Theis Fabian J, Tschöp Matthias H, Müller Timo D

GLP-1/GIP/GCG receptor triagonist (IUB447) enhances insulin secretion via GLP-1 receptor and Gαq signalling pathway in mice

GLP-1/GIP/GCG受体三激动剂(IUB447)通过GLP-1受体和Gαq信号通路增强小鼠胰岛素分泌。

Schreier, Pascale C F; Beyerle, Philipp; Boulassel, Severin; Beck, Andreas; Novikoff, Aaron; Reinach, Peter S; Boekhoff, Ingrid; Breit, Andreas; Neuberger, Arthur; Müller, Timo D; Serrano, Alberto Cebrian; Gudermann, Thomas; Khajavi, Noushafarin

Glucose-dependent insulinotropic polypeptide (GIP)

葡萄糖依赖性促胰岛素多肽(GIP)

Müller, Timo D; Adriaenssens, Alice; Ahrén, Bo; Blüher, Matthias; Birkenfeld, Andreas L; Campbell, Jonathan E; Coghlan, Matthew P; D'Alessio, David; Deacon, Carolyn F; DelPrato, Stefano; Douros, Jonathan D; Drucker, Daniel J; Figueredo Burgos, Natalie S; Flatt, Peter R; Finan, Brian; Gimeno, Ruth E; Gribble, Fiona M; Hayes, Matthew R; Hölscher, Christian; Holst, Jens J; Knerr, Patrick J; Knop, Filip K; Kusminski, Christine M; Liskiewicz, Arkadiusz; Mabilleau, Guillaume; Mowery, Stephanie A; Nauck, Michael A; Novikoff, Aaron; Reimann, Frank; Roberts, Anna G; Rosenkilde, Mette M; Samms, Ricardo J; Scherer, Philip E; Seeley, Randy J; Sloop, Kyle W; Wolfrum, Christian; Wootten, Denise; DiMarchi, Richard D; Tschöp, Matthias H

A GLP-1 analogue optimized for cAMP-biased signaling improves weight loss in obese mice.

针对 cAMP 偏向信号传导优化的 GLP-1 类似物可改善肥胖小鼠的体重减轻

Douros Jonathan D, Novikoff Aaron, DuBois Barent, Rohlfs Rebecca, Mokrosinski Jacek, Hogendorf Wouter F J, Augustin Robert, Merkestein Myrte, Egaa Martini Lene Brandt, Linderoth Lars, Gerrard Elliot, Kodra Janos Tibor, Norlin Jenny, Roed Nikolaj Kulahin, Oldenburger Anouk, Mowery Stephanie A, Waldhoer Maria, Perez-Tilve Diego, Finan Brian, Reedtz-Runge Steffen, Müller Timo D, Knerr Patrick J

Estrogenic activity of E2-conjugated GLP-1 is mediated by intracellular endolysosomal acidification and estrone metabolism.

E2 结合的 GLP-1 的雌激素活性是通过细胞内溶酶体酸化和雌酮代谢介导的

Coupland Callum, Sun Na, Khalil Ahmed, Karaoglu Özüm Ezgi, Liskiewicz Arkadiusz, Liskiewicz Daniela, Grandl Gerald, Akindehin Seun, Maity Gandhari, Yang Bin, Finan Brian, Knerr Patrick, Douros Jonathan D, Walch Axel, DiMarchi Richard, Tschöp Matthias H, Müller Timo D, Novikoff Aaron

Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity

整体、神经元或 β 细胞特异性受体缺失可改善饮食诱导肥胖雄性小鼠的血糖稳态

Gerald Grandl #, Gustav Collden #, Jin Feng #, Sreya Bhattacharya #, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Cac

Recent achievements and future directions of anti-obesity medications

抗肥胖药物的最新进展和未来发展方向

Grandl, Gerald; Novikoff, Aaron; Liu, Xue; Müller, Timo D

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

肠促胰岛素联合激动剂 tirzepatide 需要 GIPR 才能从人类胰岛分泌激素

Kimberley El #, Jonathan D Douros #, Francis S Willard, Aaron Novikoff, Ashot Sargsyan, Diego Perez-Tilve, David B Wainscott, Bin Yang, Alex Chen, Donald Wothe, Callum Coupland, Mattias H Tschöp, Brian Finan, David A D'Alessio, Kyle W Sloop, Timo D Müller, Jonathan E Campbell5