日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

激酶受损的 BTK 突变易受临床阶段 BTK 和 IKZF1/3 降解剂 NX-2127 的影响

Skye Montoya #, Jessie Bourcier #, Mark Noviski #, Hao Lu #, Meghan C Thompson, Alexandra Chirino, Jacob Jahn, Anya K Sondhi, Stefan Gajewski, Ying Siow May Tan, Stephanie Yung, Aleksandra Urban, Eric Wang, Cuijuan Han, Xiaoli Mi, Won Jun Kim, Quinlan Sievers, Paul Auger, Hugo Bousquet, Nivetha Brat

Medical students' motivations for participating in an elective focused on social inequalities and health disparities

医学生选修以社会不平等和健康差异为主题的课程的动机

Arps, Shahna; Noviski, Krista McCarthy; Tucker, Lauren; Tutwiler, Ameisha

NRX-0492 degrades wild-type and C481 mutant BTK and demonstrates in vivo activity in CLL patient-derived xenografts

NRX-0492 可降解野生型和 C481 突变型 BTK,并在 CLL 患者来源的异种移植模型中显示出体内活性。

Deyi Zhang ,Hailey M Harris ,Jonathan Chen ,Jen Judy ,Gabriella James ,Aileen Kelly ,Joel McIntosh ,Austin Tenn-McClellan ,Eileen Ambing ,Ying Siow Tan ,Hao Lu ,Stefan Gajewski ,Matthew C Clifton ,Stephanie Yung ,Daniel W Robbins ,Mehdi Pirooznia ,Sigrid S Skånland ,Erika Gaglione ,Maissa Mhibik ,Chingiz Underbayev ,Inhye E Ahn ,Clare Sun ,Sarah E M Herman ,Mark Noviski ,Adrian Wiestner

NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting

当第二信号缺失或限制时,NR4A 核受体会抑制 B 细胞对抗原的反应

Corey Tan #, Ryosuke Hiwa #, James L Mueller, Vivasvan Vykunta, Kenta Hibiya, Mark Noviski, John Huizar, Jeremy F Brooks, Jose Garcia, Cheryl Heyn, Zhongmei Li, Alexander Marson, Julie Zikherman

Self-reactivity on a spectrum: A sliding scale of peripheral B cell tolerance

自身反应性的连续谱:外周B细胞耐受性的滑动标度

Tan, Corey; Noviski, Mark; Huizar, John; Zikherman, Julie

Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery

Nur77通过限制外周自身反应性B细胞的存活,将慢性抗原刺激与B细胞耐受性联系起来。

Tan, Corey; Mueller, James L; Noviski, Mark; Huizar, John; Lau, Denise; Dubinin, Alexandra; Molofsky, Ari; Wilson, Patrick C; Zikherman, Julie

Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens

成熟B细胞的最佳发育需要识别内源性抗原

Noviski, Mark; Tan, Corey; Huizar, John; Vykunta, Vivasvan; Mueller, James L; Zikherman, Julie

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate

IgM 和 IgD B 细胞受体对内源性抗原的反应不同,并控制 B 细胞的命运。

Mark Noviski ,James L Mueller ,Anne Satterthwaite ,Lee Ann Garrett-Sinha ,Frank Brombacher ,Julie Zikherman

Control of autoreactive B cells by IgM and IgD B cell receptors: maintaining a fine balance

IgM和IgD B细胞受体对自身反应性B细胞的控制:维持微妙的平衡

Noviski, Mark; Zikherman, Julie

Nur77 Is Upregulated in B-1a Cells by Chronic Self-Antigen Stimulation and Limits Generation of Natural IgM Plasma Cells

慢性自身抗原刺激可上调 B-1a 细胞中 Nur77 的表达,并限制天然 IgM 浆细胞的生成。

Huizar, John; Tan, Corey; Noviski, Mark; Mueller, James L; Zikherman, Julie