日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
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影响因子:
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A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

一类新型共价抑制剂可阻断核苷酸与丙酮酸激酶活性位点的结合

期刊:Biochemical Journal
影响因子:4.3
doi:10.1042/BJ20121014
Morgan Hugh P, Walsh Martin J, Blackburn Elizabeth A, Wear Martin A, Boxer Matthew B, Shen Min, Veith Henrike, McNae Iain W, Nowicki Matthew W, Michels Paul A M, Auld Douglas S, Fothergill-Gilmore Linda A, Walkinshaw Malcolm D
其它
发表日期：2012
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The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.

锥虫杀灭药物苏拉明和其他锥虫蓝类似物是丙酮酸激酶抑制剂，可与腺苷结合

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M110.212613
Morgan Hugh P, McNae Iain W, Nowicki Matthew W, Zhong Wenhe, Michels Paul A M, Auld Douglas S, Fothergill-Gilmore Linda A, Walkinshaw Malcolm D
其它
药物研究
发表日期：2011
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High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase

高通量筛选获得了利什曼原虫CRK3:CYC6细胞周期蛋白依赖性激酶的小分子抑制剂

期刊:PLoS Neglected Tropical Diseases
影响因子:3.4
doi:10.1371/journal.pntd.0001033
Walker, Roderick G; Thomson, Graeme; Malone, Kirk; Nowicki, Matthew W; Brown, Elaine; Blake, David G; Turner, Nicholas J; Walkinshaw, Malcolm D; Grant, Karen M; Mottram, Jeremy C
信号转导
细胞生物学
CYC
发表日期：2011
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Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model

墨西哥利什曼原虫丙酮酸激酶的变构机制采用摇锁模型

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.M109.079905
Morgan, Hugh P; McNae, Iain W; Nowicki, Matthew W; Hannaert, Véronique; Michels, Paul A M; Fothergill-Gilmore, Linda A; Walkinshaw, Malcolm D
信号转导
发表日期：2010
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