日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Unfolding and Degradation of Micellar Immunodrug Carriers Derived From End Group Modified Aliphatic Poly(Carbonate)s with Acid-Responsive Ketal Side Groups

末端基团修饰的脂肪族聚碳酸酯与酸响应性缩酮侧基衍生的胶束免疫药物载体的展开和降解

期刊:Advanced Materials
影响因子:26.8
doi:10.1002/adma.202511752
Hauck, Adrian V; Fichter, Michael; Rosenberger, Laura J; Willig, Jannis; Fuchs, Alexander; Schön, Felicia; Schneider, Paul; Medina-Montano, Carolina; Ahmad, Taufiq; Erlenbusch, Jessica; Besenius, Pol; Kaps, Leonard; Bros, Matthias; Grabbe, Stephan; Mailänder, Volker; Groll, Jürgen; Nuhn, Lutz
免疫/内分泌
发表日期：2026
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Nanobodies targeting the tumor microenvironment and their formulation as nanomedicines

靶向肿瘤微环境的纳米抗体及其纳米药物制剂

期刊:Molecular Cancer
影响因子:33.9
doi:10.1186/s12943-025-02270-5
Maksymova, Liudmyla; Pilger, Yannick A; Nuhn, Lutz; Van Ginderachter, Jo A
肿瘤
肿瘤微环境
肿瘤免疫
发表日期：2025
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Enhancing anti-tumor immunity through intratumoral combination therapy with amphiphilic conjugates of oxaliplatin and imidazoquinoline TLR7/8 agonist.

通过肿瘤内联合治疗，将奥沙利铂和咪唑喹啉 TLR7/8 激动剂的两亲性缀合物与肿瘤内联合治疗，增强抗肿瘤免疫力

期刊:RSC Advances
影响因子:4.6
doi:10.1039/d5ra00163c
Verschuere Hanne, Kasmi Sabah, Nuhn Lutz, D'Almeida Sènan Mickaël, Zhu Qiwen, Zhong Zifu, Adjemian Sandy, Louage Benoit, De Vrieze Jana, Yu Haijun, De Geest Bruno G, Vandenabeele Peter
肿瘤
肿瘤免疫
发表日期：2025
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Hemiacetal Ester Side Chains as a Mild Protecting Group for Carboxylic Acids in Polycarbonate Backbones

半缩醛酯侧链作为聚碳酸酯骨架中羧酸的温和保护基

期刊:Macromolecular Rapid Communications
影响因子:4.3
doi:10.1002/marc.202500082
Bixenmann, Leon; Nuhn, Lutz
发表日期：2025
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PH-Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2-Propionic-3-Methyl-maleic Anhydrides with Cholesteryl End Groups

利用胆固醇末端基团的聚合物2-丙酸-3-甲基马来酸酐实现PH触发的淋巴结靶向免疫药物释放

期刊:Advanced Healthcare Materials
影响因子:9.6
doi:10.1002/adhm.202402875
Heck, Alina G; Medina-Montano, Carolina; Zhong, Zifu; Deswarte, Kim; Eigen, Katharina; Stickdorn, Judith; Kockelmann, Johannes; Scherger, Maximilian; Sanders, Niek N; Lienenklaus, Stefan; Lambrecht, Bart N; Grabbe, Stephan; De Geest, Bruno G; Nuhn, Lutz
代谢
免疫/内分泌
发表日期：2024
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Reversible Polymer-Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers

通过在RAFT衍生的聚合物上逐步引入胺反应性、还原响应性自裂解端基，实现可逆的聚合物-蛋白质功能化

期刊:ACS Biomaterials Science & Engineering
影响因子:5.5
doi:10.1021/acsbiomaterials.2c01106
Scherger, Maximilian; Pilger, Yannick A; Komforth, Patric; Räder, Hans-Joachim; Nuhn, Lutz
发表日期：2024
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Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors

全身给药的TLR7/8激动剂和抗原偶联纳米凝胶调控抗肿瘤免疫反应

期刊:ACS Nano
影响因子:16
doi:10.1021/acsnano.1c10709
Stickdorn, Judith; Stein, Lara; Arnold-Schild, Danielle; Hahlbrock, Jennifer; Medina-Montano, Carolina; Bartneck, Joschka; Ziß, Tanja; Montermann, Evelyn; Kappel, Cinja; Hobernik, Dominika; Haist, Maximilian; Yurugi, Hajime; Raabe, Marco; Best, Andreas; Rajalingam, Krishnaraj; Radsak, Markus P; David, Sunil A; Koynov, Kaloian; Bros, Matthias; Grabbe, Stephan; Schild, Hansjörg; Nuhn, Lutz
肿瘤
肿瘤免疫
TLR7
信号转导
免疫/内分泌
发表日期：2022
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pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages

pH可降解的双膦酸盐负载纳米凝胶通过M2型巨噬细胞的再极化来减轻肝纤维化

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2122310119
Kaps, Leonard; Huppertsberg, Anne; Choteschovsky, Niklas; Klefenz, Adrian; Durak, Feyza; Schrörs, Babara; Diken, Mustafa; Eichler, Emma; Rosigkeit, Sebastian; Schmitt, Sascha; Leps, Christian; Schulze, Alicia; Foerster, Friedrich; Bockamp, Ernesto; De Geest, Bruno G; Koynov, Kaloian; Räder, Hans-Joachim; Tenzer, Stefan; Marini, Federico; Schuppan, Detlef; Nuhn, Lutz
巨噬细胞
巨噬细胞
细胞生物学
免疫/内分泌
发表日期：2022
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Nontoxic N-Heterocyclic Olefin Catalyst Systems for Well-Defined Polymerization of Biocompatible Aliphatic Polycarbonates

用于生物相容性脂肪族聚碳酸酯明确聚合的无毒N-杂环烯烃催化剂体系

期刊:ACS Polymers Au
影响因子:6.9
doi:10.1021/acspolymersau.2c00017
Czysch, Christian; Dinh, Thi; Fröder, Yannick; Bixenmann, Leon; Komforth, Patric; Balint, Alexander; Räder, Hans-Joachim; Naumann, Stefan; Nuhn, Lutz
发表日期：2022
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Fluorescence Correlation Spectroscopy Monitors the Fate of Degradable Nanocarriers in the Blood Stream

荧光相关光谱法监测血液中可降解纳米载体的命运

期刊:Biomacromolecules
影响因子:5.4
doi:10.1021/acs.biomac.1c01407
Schmitt, Sascha; Huppertsberg, Anne; Klefenz, Adrian; Kaps, Leonard; Mailänder, Volker; Schuppan, Detlef; Butt, Hans-Jürgen; Nuhn, Lutz; Koynov, Kaloian
IF
发表日期：2022
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