日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Engineered coagulation factor VIII with enhanced secretion and coagulation potential for hemophilia A gene therapy

用于血友病A基因治疗的具有增强分泌和凝血潜能的工程化凝血因子VIII

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2025028481
Kashiwakura, Yuji; Nakajima, Yuto; Horinaka, Kio; Lopes, Tiago J S; Furuta, Yuma; Yamaguchi, Yuki; Baatartsogt, Nemekhbayar; Hayakawa, Morisada; Katakai, Yuko; Uchiyama, Susumu; Nureki, Osamu; Nogami, Keiji; Ohmori, Tsukasa
基因治疗
发表日期：2026
文献求助 收藏

Therapeutic base editing to generate a gain-of-function F9 variant for hemophilia B

利用治疗性碱基编辑技术生成治疗B型血友病的F9功能增强型变体。

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2024027870
Baatartsogt, Nemekhbayar; Kashiwakura, Yuji; Hiramoto, Takafumi; Ito, Rina; Sato, Rikako; Nagao, Yasumitsu; Naruoka, Hina; Takata, Haruka; Hayakawa, Morisada; Batjargal, Khishigjargal; Togashi, Tomoki; Hoshino, Atsushi; Shimizu, Taro; Sato, Yusuke; Ishida, Tatsuhiro; Nureki, Osamu; Ohmori, Tsukasa
碱基编辑
发表日期：2026
文献求助 收藏

Engineering a compact high-fidelity Staphylococcus aureus Cas9 variant with broader targeting range and mechanistic insights into its activation

构建一种结构紧凑、高保真度的金黄色葡萄球菌Cas9变体，使其具有更广泛的靶向范围，并深入了解其激活机制。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-71626-2
Omura, Satoshi N; Nakagawa, Ryoya; Kajimoto, Shohei; Okazaki, Sae; Ishiguro, Soh; Mori, Hideto; Onishi, Kosuke; Kashiwakura, Yuji; Hiramoto, Takafumi; Horinaka, Kio; Tanaka, Mamoru; Hirano, Hisato; Jividen, Kasey; Yamashita, Keitaro; Tsai, Shengdar Q; Yachie, Nozomu; Ohmori, Tsukasa; Nishimasu, Hiroshi; Nureki, Osamu
发表日期：2026
文献求助 收藏

HUH-tagged Cas9 as a platform for efficient ssODN-mediated knock-in via embryo and adult injection in insects.

HUH标记的Cas9作为平台，可通过胚胎和成虫注射在昆虫中高效地进行ssODN介导的基因敲入。

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-026-09777-7
Shirai Yu, Kao Jonchee A, Kumar Tarun, Matsuda Naoki, Nakagawa Ryoya, Nureki Osamu, Extavour Cassandra G, Daimon Takaaki
CAS9
发表日期：2026
文献求助 收藏

Structural insights into light harvesting by antenna-containing rhodopsins in marine Asgard archaea.

海洋阿斯加德古菌中含天线视紫红质的光捕获结构解析

期刊:Nature Microbiology
影响因子:19.4
doi:10.1038/s41564-025-02016-5
Tzlil Gali, Marín María Del Carmen, Matsuzaki Yuma, Nag Probal, Itakura Shota, Mizuno Yosuke, Murakoshi Shunya, Tanaka Tatsuki, Larom Shirley, Konno Masae, Abe-Yoshizumi Rei, Molina-Márquez Ana, Bárcenas-Pérez Daniela, Cheel José, Koblížek Michal, León Rosa, Katayama Kota, Kandori Hideki, Schapiro Igor, Shihoya Wataru, Nureki Osamu, Inoue Keiichi, Rozenberg Andrey, Chazan Ariel, Béjà Oded
微生物学
发表日期：2025
文献求助 收藏

Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.

CXC趋化因子受体CXCR2的混杂趋化因子结合和结构模拟的分子基础

期刊:Molecular Cell
影响因子:16.6
doi:10.1016/j.molcel.2025.01.024
Saha Shirsha, Sano Fumiya K, Sharma Saloni, Ganguly Manisankar, Mishra Sudha, Dalal Annu, Akasaka Hiroaki, Kobayashi Takaaki A, Zaidi Nashrah, Tiwari Divyanshu, Roy Nabarun, Yadav Manish K, Banerjee Nilanjana, Saha Sayantan, Mohapatra Samanwita, Itoh Yuzuru, Chevigné Andy, Banerjee Ramanuj, Shihoya Wataru, Nureki Osamu, Shukla Arun K
其它
发表日期：2025
文献求助 收藏

Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens

克氏藻（Klebsormidium nitens）蓝移通道视紫红质的冷冻电镜结构

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59299-9
Wang, Yuzhu Z; Natsume, Koki; Tanaka, Tatsuki; Hososhima, Shoko; Tashiro, Rintaro; Sano, Fumiya K; Akasaka, Hiroaki; Tsunoda, Satoshi P; Shihoya, Wataru; Kandori, Hideki; Nureki, Osamu
发表日期：2025
文献求助 收藏

Structural basis of anticancer drug recognition and amino acid transport by LAT1

LAT1 识别抗癌药物和转运氨基酸的结构基础

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-56903-w
Lee, Yongchan; Jin, Chunhuan; Ohgaki, Ryuichi; Xu, Minhui; Ogasawara, Satoshi; Warshamanage, Rangana; Yamashita, Keitaro; Murshudov, Garib; Nureki, Osamu; Murata, Takeshi; Kanai, Yoshikatsu
肿瘤
LAT
肿瘤免疫
LAT1
发表日期：2025
文献求助 收藏

A mini-hairpin shaped nascent peptide blocks translation termination by a distinct mechanism

微型发夹状新生肽通过一种独特的机制阻断翻译终止。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-57659-z
Ando, Yushin; Kobo, Akinao; Niwa, Tatsuya; Yamakawa, Ayako; Konoma, Suzuna; Kobayashi, Yuki; Nureki, Osamu; Taguchi, Hideki; Itoh, Yuzuru; Chadani, Yuhei
发表日期：2025
文献求助 收藏

Expanded genetic alphabet increases structural and chemical diversity of six-letter DNA for high-affinity protein-targeting aptamers

扩展的遗传字母表增加了六字母DNA的结构和化学多样性，从而提高了高亲和力蛋白质靶向适配体的数量。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-67486-x
Sawada, Kazuhiro; Kimoto, Michiko; Matsunaga, Ken-Ichiro; Tan, Hui Pen; Takayanagi, Ryu; Sano, Fumiya K; Shuto, Yutaro; Hirano, Hisato; Kusakizako, Tsukasa; Itoh, Yuzuru; Kise, Yoshiaki; Hirao, Ichiro; Nureki, Osamu
发表日期：2025
文献求助 收藏