日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.

纠正脂质代谢紊乱可使少突胶质细胞中的基因表达正常化,并延长雌性 poly-GA C9orf72 小鼠的寿命

Rezaei Ali, Kocsis-Jutka Virág, Gunes Zeynep I, Zeng Qing, Kislinger Georg, Bauernschmitt Franz, Isilgan Huseyin Berkcan, Parisi Laura R, Kaya Tuğberk, Franzenburg Sören, Koppenbrink Jonas, Knogler Julia, Arzberger Thomas, Farny Daniel, Nuscher Brigitte, Katona Eszter, Dhingra Ashutosh, Yang Chao, Gouna Garyfallia, LaClair Katherine D, Janjic Aleksandar, Enard Wolfgang, Zhou Qihui, Hagan Nellwyn, Ofengeim Dimitry, Beltrán Eduardo, Gokce Ozgun, Simons Mikael, Liebscher Sabine, Edbauer Dieter

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques

早期干预抗Aβ免疫疗法可减轻小胶质细胞活化,而不会导致残余斑块处的细胞耗竭。

Lis de Weerd ,Selina Hummel ,Stephan A Müller ,Iñaki Paris ,Thomas Sandmann ,Marie Eichholtz ,Robin Gröger ,Amelie L Englert ,Stephan Wagner ,Connie Ha ,Sonnet S Davis ,Valerie Warkins ,Dan Xia ,Brigitte Nuscher ,Anna Berghofer ,Marvin Reich ,Astrid F Feiten ,Kai Schlepckow ,Michael Willem ,Stefan F Lichtenthaler ,Joseph W Lewcock ,Kathryn M Monroe ,Matthias Brendel ,Christian Haass

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Tau 单体和聚集体在人类神经元中的吸收和细胞内积累的独特调节

Amir T Marvian, Tabea Strauss, Qilin Tang, Benjamin J Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S Sutherland, William A McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F Lichtenthaler, Wo

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

内源性 TDP-43 的错误定位导致类似 ALS 的早期代谢功能障碍和进行性运动障碍

Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

Association of Neurofilament Light Chain, [(18)F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS

神经丝轻链、[(18)F]PI-2620 Tau-PET、TSPO-PET 与 β-淀粉样蛋白阴性皮质基底节变性综合征患者临床进展的相关性

Palleis, Carla; Franzmeier, Nicolai; Weidinger, Endy; Bernhardt, Alexander M; Katzdobler, Sabrina; Wall, Stephan; Ferschmann, Christian; Harris, Stefanie; Schmitt, Julia; Schuster, Sebastian; Gnörich, Johannes; Finze, Anika; Biechele, Gloria; Lindner, Simon; Albert, Nathalie L; Bartenstein, Peter; Sabri, Osama; Barthel, Henryk; Rupprecht, Rainer; Nuscher, Brigitte; Stephens, Andrew W; Rauchmann, Boris-Stephan; Perneczky, Robert; Haass, Christian; Brendel, Matthias; Levin, Johannes; Höglinger, Günter U

Early Neuroaxonal Damage in Neurologic Disorders Associated With GAD65 Antibodies

GAD65抗体相关神经系统疾病中的早期神经轴突损伤

Eisenhut, Katharina; Faber, Jennifer; Engels, Daniel; Gerhards, Ramona; Lewerenz, Jan; Doppler, Kathrin; Sommer, Claudia; Markewitz, Robert; Falk, Kim K; Rössling, Rosa; Pruess, Harald; Finke, Carsten; Wickel, Jonathan; Geis, Christian; Ratuszny, Dominica; Pfeffer, Lena K; Bittner, Stefan; Piepgras, Johannes; Kraft, Andrea; Klausewitz, Jaqueline; Nuscher, Brigitte; Kümpfel, Tania; Thaler, Franziska S

GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)

GFAP 和 NfL 作为多系统萎缩症 (MSA) 临床疾病严重程度和疾病进展的体液生物标志物

Katzdobler, Sabrina; Nübling, Georg; Klietz, Martin; Fietzek, Urban M; Palleis, Carla; Bernhardt, Alexander M; Wegner, Florian; Huber, Meret; Rogozinski, Sophia; Schneider, Luisa-Sophie; Spruth, Eike Jakob; Beyle, Aline; Vogt, Ina R; Brandt, Moritz; Hansen, Niels; Glanz, Wenzel; Brockmann, Kathrin; Spottke, Annika; Hoffmann, Daniel C; Peters, Oliver; Priller, Josef; Wiltfang, Jens; Düzel, Emrah; Schneider, Anja; Falkenburger, Björn; Klockgether, Thomas; Gasser, Thomas; Nuscher, Brigitte; Haass, Christian; Höglinger, Günter; Levin, Johannes

Lewy body pathology in autosomal dominant and sporadic Alzheimer’s disease – neuropathological distribution patterns and associated survival and genetic findings

常染色体显性遗传和散发性阿尔茨海默病中的路易体病理——神经病理分布模式及相关的生存和遗传学发现

Wittchen, Hans-Ulrich; Beesdo-Baum, Katja; Kamps, Suzie; Hempel, Hugo L; van Amerongen, Suzan; de Bruin, Hannah; van der Linden, Fleur HC; Barkhof, Frederik; Scheltens, Philip; Ossenkoppele, Rik; Vijverberg, Everard GB; Moscoso, Alexis; van Essen, Martijn; Mainta, Isminni; Camacho, Valle; Rodríguez‐Fonseca, Omar; Silva‐Rodríguez, Jesús; Perissinotti, Andrés; Franzmeier, Nicolai; Grothe, Michel J; Frisoni, Giovanni B; Garibotto, Valentina; Schöll, Michael; Dewenter, Anna; Dehsarvi, Amir; Steward, Anna; Biel, Davina; Pescoller, Julia; Zhu, Zeyu; Wagner, Fabian; Gross, Mattes; Nuscher, Brigitte; Roemer, Sebastian Niclas; Buerger, Katharina; Janowitz, Daniel; Ewers, Michael; Tiedt, Steffen; Dichgans, Martin; Brendel, Matthias; Franzmeier, Nicolai; Kamps, Suzie; Hempel, Hugo L; van Amerongen, Suzan; de Bruin, Hannah; van der Linden, Fleur HC; Barkhof, Frederik; Scheltens, Philip; Ossenkoppele, Rik; Vijverberg, Everard GB; Rauchmann, Boris‐Stephan; Guersel, Selim Üstün; Kurz, Carolin Isabella; Lindner, Simon; Franzmeier, Nicolai; Buerger, Katharina; Gnörich, Johannes; Zaganjori, Mirlind; Vogler, Letitia; Sanzo, Laura; Seelos, Klaus; Perneczky, Robert; Brendel, Matthias; Vöglein, Jonathan; Ryan, Natalie S; Cruchaga, Carlos; Gorijala, Priyanka; Bateman, Randall J; McDade, Eric; Paumier, Katrina L; Cairns, Nigel J; Franklin, Erin E; Xiong, Chengjie; Jucker, Mathias; Lashley, Tammaryn; Arzberger, Thomas; Herms, Jochen; Perrin, Richard J; Danek, Adrian; Höglinger, Günter; Morris, John C; Fox, Nick C; Levin, Johannes

Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

利用抗体靶向 TDP-43 富含甘氨酸的结构域可防止其在体外聚集,并降低体内神经丝水平

Henrick Riemenschneider, Francesca Simonetti #, Udit Sheth #, Eszter Katona #, Stefan Roth, Saskia Hutten, Daniel Farny, Meike Michaelsen, Brigitte Nuscher, Michael K Schmidt, Andrew Flatley, Aloys Schepers, Lara A Gruijs da Silva, Qihui Zhou, Thomas Klopstock, Arthur Liesz, Thomas Arzberger, Jochen