日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

TREM2表达水平对小胶质细胞状态、代谢能力和TREM2激动剂的疗效至关重要。

Feiten, Astrid F; Dahm, Kilian; Schlepckow, Kai; van Lengerich, Bettina; Suh, Jung H; Reifschneider, Anika; Wefers, Benedikt; Bartos, Laura M; Wind-Mark, Karin; de Weerd, Lis; Ulas, Thomas; De-Domenico, Elena; Grundschöttel, Pia; Paulusch, Stefan; Tast, Benjamin; Honda, Tamisa; Müller, Stephan A; Becker, Matthias; Khalin, Igor; Ricci, Alessio; Liesz, Arthur; Brunner, Bettina; Krenner, Claudia; Buschmann, Katrin; Nuscher, Brigitte; Spieth, Lena; Junker, Niklas; Berghoff, Stefan A; Davis, Sonnet S; Neher, Jonas J; Wurst, Wolfgang; Plesnila, Nikolaus; Lewcock, Joseph W; Simons, Mikael; Lichtenthaler, Stefan F; Di Paolo, Gilbert; Brendel, Matthias; Capell, Anja; Monroe, Kathryn M; Schultze, Joachim L; Haass, Christian

Correction of dysregulated lipid metabolism normalizes gene expression in oligodendrocytes and prolongs lifespan in female poly-GA C9orf72 mice.

纠正脂质代谢紊乱可使少突胶质细胞中的基因表达正常化,并延长雌性 poly-GA C9orf72 小鼠的寿命

Rezaei Ali, Kocsis-Jutka Virág, Gunes Zeynep I, Zeng Qing, Kislinger Georg, Bauernschmitt Franz, Isilgan Huseyin Berkcan, Parisi Laura R, Kaya Tuğberk, Franzenburg Sören, Koppenbrink Jonas, Knogler Julia, Arzberger Thomas, Farny Daniel, Nuscher Brigitte, Katona Eszter, Dhingra Ashutosh, Yang Chao, Gouna Garyfallia, LaClair Katherine D, Janjic Aleksandar, Enard Wolfgang, Zhou Qihui, Hagan Nellwyn, Ofengeim Dimitry, Beltrán Eduardo, Gokce Ozgun, Simons Mikael, Liebscher Sabine, Edbauer Dieter

Association of Neurofilament Light Chain, [(18)F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS

神经丝轻链、[(18)F]PI-2620 Tau-PET、TSPO-PET 与 β-淀粉样蛋白阴性皮质基底节变性综合征患者临床进展的相关性

Palleis, Carla; Franzmeier, Nicolai; Weidinger, Endy; Bernhardt, Alexander M; Katzdobler, Sabrina; Wall, Stephan; Ferschmann, Christian; Harris, Stefanie; Schmitt, Julia; Schuster, Sebastian; Gnörich, Johannes; Finze, Anika; Biechele, Gloria; Lindner, Simon; Albert, Nathalie L; Bartenstein, Peter; Sabri, Osama; Barthel, Henryk; Rupprecht, Rainer; Nuscher, Brigitte; Stephens, Andrew W; Rauchmann, Boris-Stephan; Perneczky, Robert; Haass, Christian; Brendel, Matthias; Levin, Johannes; Höglinger, Günter U

GFAP and NfL as fluid biomarkers for clinical disease severity and disease progression in multiple system atrophy (MSA)

GFAP 和 NfL 作为多系统萎缩症 (MSA) 临床疾病严重程度和疾病进展的体液生物标志物

Katzdobler, Sabrina; Nübling, Georg; Klietz, Martin; Fietzek, Urban M; Palleis, Carla; Bernhardt, Alexander M; Wegner, Florian; Huber, Meret; Rogozinski, Sophia; Schneider, Luisa-Sophie; Spruth, Eike Jakob; Beyle, Aline; Vogt, Ina R; Brandt, Moritz; Hansen, Niels; Glanz, Wenzel; Brockmann, Kathrin; Spottke, Annika; Hoffmann, Daniel C; Peters, Oliver; Priller, Josef; Wiltfang, Jens; Düzel, Emrah; Schneider, Anja; Falkenburger, Björn; Klockgether, Thomas; Gasser, Thomas; Nuscher, Brigitte; Haass, Christian; Höglinger, Günter; Levin, Johannes

Lewy body pathology in autosomal dominant and sporadic Alzheimer’s disease – neuropathological distribution patterns and associated survival and genetic findings

常染色体显性遗传和散发性阿尔茨海默病中的路易体病理——神经病理分布模式及相关的生存和遗传学发现

Wittchen, Hans-Ulrich; Beesdo-Baum, Katja; Kamps, Suzie; Hempel, Hugo L; van Amerongen, Suzan; de Bruin, Hannah; van der Linden, Fleur HC; Barkhof, Frederik; Scheltens, Philip; Ossenkoppele, Rik; Vijverberg, Everard GB; Moscoso, Alexis; van Essen, Martijn; Mainta, Isminni; Camacho, Valle; Rodríguez‐Fonseca, Omar; Silva‐Rodríguez, Jesús; Perissinotti, Andrés; Franzmeier, Nicolai; Grothe, Michel J; Frisoni, Giovanni B; Garibotto, Valentina; Schöll, Michael; Dewenter, Anna; Dehsarvi, Amir; Steward, Anna; Biel, Davina; Pescoller, Julia; Zhu, Zeyu; Wagner, Fabian; Gross, Mattes; Nuscher, Brigitte; Roemer, Sebastian Niclas; Buerger, Katharina; Janowitz, Daniel; Ewers, Michael; Tiedt, Steffen; Dichgans, Martin; Brendel, Matthias; Franzmeier, Nicolai; Kamps, Suzie; Hempel, Hugo L; van Amerongen, Suzan; de Bruin, Hannah; van der Linden, Fleur HC; Barkhof, Frederik; Scheltens, Philip; Ossenkoppele, Rik; Vijverberg, Everard GB; Rauchmann, Boris‐Stephan; Guersel, Selim Üstün; Kurz, Carolin Isabella; Lindner, Simon; Franzmeier, Nicolai; Buerger, Katharina; Gnörich, Johannes; Zaganjori, Mirlind; Vogler, Letitia; Sanzo, Laura; Seelos, Klaus; Perneczky, Robert; Brendel, Matthias; Vöglein, Jonathan; Ryan, Natalie S; Cruchaga, Carlos; Gorijala, Priyanka; Bateman, Randall J; McDade, Eric; Paumier, Katrina L; Cairns, Nigel J; Franklin, Erin E; Xiong, Chengjie; Jucker, Mathias; Lashley, Tammaryn; Arzberger, Thomas; Herms, Jochen; Perrin, Richard J; Danek, Adrian; Höglinger, Günter; Morris, John C; Fox, Nick C; Levin, Johannes

Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study

脑脊液中可溶性TREM2及其与常染色体显性遗传阿尔茨海默病患者其他生物标志物和认知功能的关系:一项纵向观察研究

Morenas-Rodríguez, Estrella; Li, Yan; Nuscher, Brigitte; Franzmeier, Nicolai; Xiong, Chengjie; Suárez-Calvet, Marc; Fagan, Anne M; Schultz, Stephanie; Gordon, Brian A; Benzinger, Tammie L S; Hassenstab, Jason; McDade, Eric; Feederle, Regina; Karch, Celeste M; Schlepckow, Kai; Morris, John C; Kleinberger, Gernot; Nellgard, Bengt; Vöglein, Jonathan; Blennow, Kaj; Zetterberg, Henrik; Ewers, Michael; Jucker, Mathias; Levin, Johannes; Bateman, Randall J; Haass, Christian

Serum glial fibrillary acidic protein and neurofilament light chain in patients with early treated phenylketonuria

早期治疗苯丙酮尿症患者的血清胶质纤维酸性蛋白和神经丝轻链

Lotz-Havla, Amelie S; Katzdobler, Sabrina; Nuscher, Brigitte; Weiß, Katharina; Levin, Johannes; Havla, Joachim; Maier, Esther M

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

脑脊液中sTREM2水平升高可降低ApoE4相关的认知衰退和神经退行性疾病风险。

Franzmeier, Nicolai; Suárez-Calvet, M; Frontzkowski, Lukas; Moore, Annah; Hohman, Timothy J; Morenas-Rodriguez, Estrella; Nuscher, Brigitte; Shaw, Leslie; Trojanowski, John Q; Dichgans, Martin; Kleinberger, Gernot; Haass, Christian; Ewers, Michael

Aβ oligomers trigger and accelerate Aβ seeding

Aβ寡聚体触发并加速Aβ种子形成

Katzmarski, Natalie; Ziegler-Waldkirch, Stephanie; Scheffler, Nina; Witt, Christian; Abou-Ajram, Claudia; Nuscher, Brigitte; Prinz, Marco; Haass, Christian; Meyer-Luehmann, Melanie

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology.

阿尔茨海默病早期脑脊液 sTREM2 的增加与 tau 蛋白相关的神经退行性变有关,但与淀粉样蛋白-β 病理无关

Suárez-Calvet Marc, Morenas-Rodríguez Estrella, Kleinberger Gernot, Schlepckow Kai, Araque Caballero Miguel Ángel, Franzmeier Nicolai, Capell Anja, Fellerer Katrin, Nuscher Brigitte, Eren Erden, Levin Johannes, Deming Yuetiva, Piccio Laura, Karch Celeste M, Cruchaga Carlos, Shaw Leslie M, Trojanowski John Q, Weiner Michael, Ewers Michael, Haass Christian