日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

hiPSC-neurons recapitulate the subtype-specific cell intrinsic nature of susceptibility to neurodegenerative disease-relevant aggregation.

hiPSC-神经元重现了亚型特异性细胞内在的易感性,这种易感性与神经退行性疾病相关的聚集有关

Weidling Ian, Preiss Christina N, Chancellor Sarah E, Srivastava Gyan, Gibilisco Lauren, Lin Gen, Brennan Melanie Shackett, Lee Janice, Roth Lindsay M, Morozova Olga, Nam Kyong Nyon, Patel Nehal R, Liu Qing, Thomas J K, Reinhardt Peter, Wilkens Ruven, Ehrnhoefer Dagmar E, Striebinger Andreas, Barghorn Stefan, Xanthopoulos Christina, Weil Marie-Theres, Biesinger Sandra, Cik Miroslav, Romanul Nandini, Yanamandra Kiran, Welker Alessandra M, Wu Jessica, Gasparini Laura, Stöhr Jan, Langlois Xavier, Manos Justine D

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Trem2 缺乏对人类 APOE3 和 APOE4 小鼠的表型和转录组产生不同的影响

Nicholas F Fitz, Cody M Wolfe, Brittany E Playso, Richard J Biedrzycki, Yi Lu, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamova

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

APOE2 调控阿尔茨海默症死后脑组织转录组和脂质组学特征的差异

Iliya Lefterov, Cody M Wolfe, Nicholas F Fitz, Kyong Nyon Nam, Florent Letronne, Richard J Biedrzycki, Julia Kofler, Xianlin Han, Jianing Wang, Jonathan Schug, Radosveta Koldamova

Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10

维生素 D(1,25(OH)2D3)可诱导 CD4+ T 细胞合成 α-1-抗胰蛋白酶,这是 1,25(OH)2D3 驱动的 IL-10 所必需的

Sarah Dimeloe, Louise V Rice, Hebe Chen, Charlotte Cheadle, John Raynes, Paul Pfeffer, Paul Lavender, David F Richards, Mun Peak Nyon, James M McDonnell, Claudia Kemper, Bibek Gooptu, Catherine M Hawrylowicz

ABCA1 haplodeficiency affects the brain transcriptome following traumatic brain injury in mice expressing human APOE isoforms

ABCA1单倍体缺乏症会影响表达人类APOE同种型的小鼠在创伤性脑损伤后的脑转录组。

Castranio, Emilie L; Wolfe, Cody M; Nam, Kyong Nyon; Letronne, Florent; Fitz, Nicholas F; Lefterov, Iliya; Koldamova, Radosveta

The Role of APOE and TREM2 in Alzheimer's Disease-Current Understanding and Perspectives

APOE和TREM2在阿尔茨海默病中的作用——目前的认识和展望

Wolfe, Cody M; Fitz, Nicholas F; Nam, Kyong Nyon; Lefterov, Iliya; Koldamova, Radosveta

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

构建稳定的 CHO 细胞系以表达 MERS 冠状病毒疫苗抗原

Mun Peak Nyon, Lanying Du, Chien-Te Kent Tseng, Christopher A Seid, Jeroen Pollet, Kevin S Naceanceno, Anurodh Agrawal, Abdullah Algaissi, Bi-Hung Peng, Wanbo Tai, Shibo Jiang, Maria Elena Bottazzi, Ulrich Strych, Peter J Hotez

Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice

综合研究揭示饮食、APOE基因型和性别影响APP小鼠的免疫反应

Nam, Kyong Nyon; Wolfe, Cody M; Fitz, Nicholas F; Letronne, Florent; Castranio, Emilie L; Mounier, Anais; Schug, Jonathan; Lefterov, Iliya; Koldamova, Radosveta

Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury

基因共表达网络确定 Trem2 和 Tyrobp 是创伤性脑损伤后人类 APOE 表达小鼠的主要枢纽

Emilie L Castranio, Anais Mounier, Cody M Wolfe, Kyong Nyon Nam, Nicholas F Fitz, Florent Letronne, Jonathan Schug, Radosveta Koldamova, Iliya Lefterov

Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice

高脂饮食对阿尔茨海默病模型小鼠表型、脑转录组和脂质组的影响

Kyong Nyon Nam, Anais Mounier, Cody M Wolfe, Nicholas F Fitz, Alexis Y Carter, Emilie L Castranio, Hafsa I Kamboh, Valerie L Reeves, Jianing Wang, Xianlin Han, Jonathan Schug, Iliya Lefterov, Radosveta Koldamova