Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication
在慢性SIV感染期间，使用PAS化拮抗剂阻断I型干扰素信号通路可抑制特定的炎症通路，但不会改变T细胞活化或病毒复制。
期刊:PLoS Pathogens
影响因子:4.9
doi:10.1371/journal.ppat.1007246
Nganou-Makamdop, Krystelle; Billingsley, James M; Yaffe, Zachary; O'Connor, Gregory; Tharp, Gregory K; Ransier, Amy; Laboune, Farida; Matus-Nicodemos, Rodrigo; Lerner, Andrea; Gharu, Lavina; Robertson, Jennifer M; Ford, Mandy L; Schlapschy, Martin; Kuhn, Nadine; Lensch, Alexandra; Lifson, Jeffrey; Nason, Martha; Skerra, Arne; Schreiber, Gideon; Bosinger, Steven E; Douek, Daniel C
炎症
T细胞
炎症/感染
信号转导
微生物学
T细胞
细胞生物学
免疫/内分泌
