日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2

Mac1 ADP-核糖水解酶是SARS-CoV-2的治疗靶点。

Suryawanshi, Rahul K; Jaishankar, Priyadarshini; Correy, Galen J; Rachman, Moira M; O'Leary, Patrick C; Taha, Taha Y; Matsui, Yusuke; Zapatero-Belinchón, Francisco J; McCavitt-Malvido, Maria; Doruk, Yagmur U; Stevens, Maisie G V; Diolaiti, Morgan E; Jogalekar, Manasi P; Chen, Huadong; Richards, Alicia L; Kongpracha, Pornparn; Bali, Sofia; Montano, Mauricio; Rosecrans, Julia; Matthay, Michael; Togo, Takaya; Gonciarz, Ryan L; Gopalkrishnan, Saumya; Neitz, R Jeffrey; Krogan, Nevan J; Swaney, Danielle L; Shoichet, Brian K; Ott, Melanie; Renslo, Adam R; Ashworth, Alan; Fraser, James S

Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer.

转录和 DNA 复制的冲突会导致大量的串联重复,并暴露出癌症中可靶向治疗的弱点

Yang Yang, Badura Michelle L, O'Leary Patrick C, Delavan Henry M, Robinson Troy M, Egusa Emily A, Zhong Xiaoming, Swinderman Jason T, Li Haolong, Zhang Meng, Kim Minkyu, Ashworth Alan, Feng Felix Y, Chou Jonathan, Yang Lixing

Resistance to ATR Inhibitors Is Mediated by Loss of the Nonsense-Mediated Decay Factor UPF2

对ATR抑制剂的耐药性是由无义介导衰变因子UPF2的缺失介导的。

O'Leary, Patrick C; Chen, Huadong; Doruk, Yagmur U; Williamson, Tess; Polacco, Benjamin; McNeal, Andrew S; Shenoy, Tanushree; Kale, Nupura; Carnevale, Julia; Stevenson, Erica; Quigley, David A; Chou, Jonathan; Feng, Felix Y; Swaney, Danielle L; Krogan, Nevan J; Kim, Minkyu; Diolaiti, Morgan E; Ashworth, Alan

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

靶向过氧化物酶1可抑制乳腺癌细胞的生长,并显著增强这些细胞对促氧化剂的敏感性。

Bajor, Malgorzata; Zych, Agata O; Graczyk-Jarzynka, Agnieszka; Muchowicz, Angelika; Firczuk, Malgorzata; Trzeciak, Lech; Gaj, Pawel; Domagala, Antoni; Siernicka, Marta; Zagozdzon, Agnieszka; Siedlecki, Pawel; Kniotek, Monika; O'Leary, Patrick C; Golab, Jakub; Zagozdzon, Radoslaw