日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome

SCN1B相关Dravet综合征小鼠模型中的共济失调和小脑兴奋性降低

Yuan, Yukun; O'Malley, Heather A; Winters, Jesse J; Lavado, Alfonso; Denomme, Nicholas S; Bakshi, Shreeya; Hodges, Samantha L; Lopez-Santiago, Luis; Chen, Chunling; Isom, Lori L

Scn1b deletion in adult mice results in seizures and SUDEP

成年小鼠中Scn1b基因缺失会导致癫痫发作和猝死。

O'Malley, Heather A; Hull, Jacob M; Clawson, Brittany C; Chen, Chunling; Owens-Fiestan, Gic; Jameson, Margaret B; Aton, Sara J; Parent, Jack M; Isom, Lori L

Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.

晚期 Na(+) 电流和延长的电恢复是老年性肌病的关键决定因素

Signore Sergio, Sorrentino Andrea, Borghetti Giulia, Cannata Antonio, Meo Marianna, Zhou Yu, Kannappan Ramaswamy, Pasqualini Francesco, O'Malley Heather, Sundman Mark, Tsigkas Nikolaos, Zhang Eric, Arranto Christian, Mangiaracina Chiara, Isobe Kazuya, Sena Brena F, Kim Junghyun, Goichberg Polina, Nahrendorf Matthias, Isom Lori L, Leri Annarosa, Anversa Piero, Rota Marcello

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

Dravet综合征患者来源的神经元提示了一种新的癫痫机制

Liu, Yu; Lopez-Santiago, Luis F; Yuan, Yukun; Jones, Julie M; Zhang, Helen; O'Malley, Heather A; Patino, Gustavo A; O'Brien, Janelle E; Rusconi, Raffaella; Gupta, Ajay; Thompson, Robert C; Natowicz, Marvin R; Meisler, Miriam H; Isom, Lori L; Parent, Jack M

PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons

PKCβ 与中脑神经元中的多巴胺转运蛋白共定位

O'Malley, Heather A; Park, Yanghae; Isom, Lori L; Gnegy, Margaret E

A functional null mutation of SCN1B in a patient with Dravet syndrome

Dravet综合征患者中发现SCN1B功能性无义突变。

Patino, Gustavo A; Claes, Lieve R F; Lopez-Santiago, Luis F; Slat, Emily A; Dondeti, Raja S R; Chen, Chunling; O'Malley, Heather A; Gray, Charles B B; Miyazaki, Haruko; Nukina, Nobuyuki; Oyama, Fumitaka; De Jonghe, Peter; Isom, Lori L

Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.

在多发性硬化症小鼠模型中,Na+通道β2亚基的缺失具有神经保护作用

O'Malley Heather A, Shreiner Andrew B, Chen Gwo-Hsiao, Huffnagle Gary B, Isom Lori L