日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome

SCN1B相关Dravet综合征小鼠模型中的共济失调和小脑兴奋性降低

Yuan, Yukun; O'Malley, Heather A; Winters, Jesse J; Lavado, Alfonso; Denomme, Nicholas S; Bakshi, Shreeya; Hodges, Samantha L; Lopez-Santiago, Luis; Chen, Chunling; Isom, Lori L

Scn1b deletion in adult mice results in seizures and SUDEP

成年小鼠中Scn1b基因缺失会导致癫痫发作和猝死。

O'Malley, Heather A; Hull, Jacob M; Clawson, Brittany C; Chen, Chunling; Owens-Fiestan, Gic; Jameson, Margaret B; Aton, Sara J; Parent, Jack M; Isom, Lori L

Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism

Dravet综合征患者来源的神经元提示了一种新的癫痫机制

Liu, Yu; Lopez-Santiago, Luis F; Yuan, Yukun; Jones, Julie M; Zhang, Helen; O'Malley, Heather A; Patino, Gustavo A; O'Brien, Janelle E; Rusconi, Raffaella; Gupta, Ajay; Thompson, Robert C; Natowicz, Marvin R; Meisler, Miriam H; Isom, Lori L; Parent, Jack M

PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons

PKCβ 与中脑神经元中的多巴胺转运蛋白共定位

O'Malley, Heather A; Park, Yanghae; Isom, Lori L; Gnegy, Margaret E

A functional null mutation of SCN1B in a patient with Dravet syndrome

Dravet综合征患者中发现SCN1B功能性无义突变。

Patino, Gustavo A; Claes, Lieve R F; Lopez-Santiago, Luis F; Slat, Emily A; Dondeti, Raja S R; Chen, Chunling; O'Malley, Heather A; Gray, Charles B B; Miyazaki, Haruko; Nukina, Nobuyuki; Oyama, Fumitaka; De Jonghe, Peter; Isom, Lori L

Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.

在多发性硬化症小鼠模型中,Na+通道β2亚基的缺失具有神经保护作用

O'Malley Heather A, Shreiner Andrew B, Chen Gwo-Hsiao, Huffnagle Gary B, Isom Lori L