日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo

引导RNA 3'末端区域中磷酸二酯骨架的存在(而非核碱基的存在)是RISC在体外和体内装载和靶标切割所必需的。

O'Reilly, Daniel; Furgal, Raymond C; Ross, Vella M; Luu, Eric; Gross, Katherine Y; Hariharan, Vignesh; Summers, Ashley; Cooper, David; Allen, Sarah; Dahlke, Christopher; Rachid, Mohamad Omar; Chan, Io Long; Fakih, Hassan H; Alterman, Julia F; Echeverria, Dimas; Watts, Jonathan K; Khvorova, Anastasia

Chemical control of 2'-hydroxyl-dependent Cas9 target engagement enables CRISPR RNA ribose replacement

通过化学方法控制 2'-羟基依赖的 Cas9 靶标结合,可以实现 CRISPR RNA 核糖替换。

Pater, Adrian A; Barber, Halle M; Sudhakar, Sruthi; Chilamkurthy, Ramadevi; Jana, Sunit K; Parasrampuria, Mansi A; Bosmeny, Michael S; Graczyk-Marrs, Jacob A; Eddington, Seth B; Blazier, Cole A; Abdullahu, Leonora; Malek-Adamian, Elise; Barkau, Christopher L; O'Reilly, Daniel; Korolev, Sergey; Pradeepkumar, P I; Damha, Masad J; Gagnon, Keith T

Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding.

通过转录抑制和直接 CAG 重复序列结合抑制亨廷顿病体细胞不稳定性。

Mathews Ella W, Coffey Sydney R, Gärtner Annette, Belgrad Jillian, Bragg Robert M, O'Reilly Daniel, Cantle Jeffrey P, McHugh Cassandra, Summers Ashley, Fentz Joachim, Schwagarus Tom, Cornelius Antje, Lingos Ioannis, Burch Zoe, Kovalenko Marina, Andrew Marissa A, Bennett C Frank, Kordasiewicz Holly B, Marchionini Deanna M, Wilkinson Hilary, Vogt Thomas F, Beuzer Paolo, Pinto Ricardo M, Khvorova Anastasia, Howland David, Wheeler Vanessa C, Carroll Jeffrey B

Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy.

对影响完全化学修饰的siRNA功效的siRNA和mRNA特征进行系统分析

Davis Sarah M, Hildebrand Samuel, MacMillan Hannah J, Monopoli Kathryn R, Buchwald Julianna, Sousa Jacquelyn, Cooper David, Ly Socheata, Echeverria Dimas, McHugh Nicholas, Ferguson Chantal, Coles Andrew, Hariharan Vignesh N, O'Reilly Daniel, Tang Qi, Furgal Raymond, Yamada Ken, Alterman Julia F, Gilbert James W, Knox Emily, Pineda Yamilett, Weston Caitlyn N, Baer Christina E, Pai Athma A, Khvorova Anastasia

Systematic Evaluation of Position-Specific Tolerability of Seven Backbone and Ribose Modifications in Fully Chemically Stabilized siRNAs

对七种骨架和核糖修饰在完全化学稳定的siRNA中的位置特异性耐受性进行系统评价

O'Reilly, Daniel; Furgal, Raymond; Hariharan, Vignesh; Lochmann, Clemens; Cooper, David; Echeverria, Dimas; Khvorova, Anastasia

Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation.

利用新表位抗体在小鼠脑中检测到突变亨廷顿蛋白外显子 1 蛋白:CAG 重复扩增、MutS 同源物 3 沉默和聚集的影响

Sapp Ellen, Boudi Adel, Iwanowicz Andrew, Belgrad Jillian, Miller Rachael, Robertson Riannon, O'Reilly Daniel, Yamada Ken, Deng Yunping, Joni Marion, Li Xueyi, Kegel-Gleason Kimberly, Khvorova Anastasia, Reiner Anton, Aronin Neil, DiFiglia Marian

Increased risk of admission to neonatal intensive care unit in neonates born to mothers with pregestational diabetes

患有妊娠前糖尿病的母亲所生的新生儿入住新生儿重症监护室的风险增加

Hillick, Dearbhla; O'Reilly, Daniel; Murphy, Lauren; Breathnach, Fionnuala; McCallion, Naomi

Acute kidney injury in late-onset neonatal bacteraemia: The role of the neonatal sequential organ failure assessment tool in predicting kidney injury

晚发型新生儿菌血症并发急性肾损伤:新生儿序贯器官衰竭评估工具在预测肾损伤中的作用

Wildes, Dermot Michael; O'Reilly, Daniel; Brennan, Elysha; Drew, Richard; Awan, Atif; Boyle, Michael A

Carbon emissions from road transport on a national neonatal transport service: a retrospective observational study

国家新生儿运输服务道路运输的碳排放:一项回顾性观察研究

Moore, Carmel Maria; O'Reilly, Daniel; Aminudin, Nurul; Purna, Jyosthsna R; Franta, Jan; Fucikova, Hana

Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study

早期血浆铁蛋白浓度与极早产儿和超早产儿红细胞输注时间无关:一项前瞻性单中心观察研究

O'Reilly, Daniel; Fox, Áine; Murphy, Lauren; Murphy, Claire; Glynn, Anna-Claire; Kelleher, Grainne; Ni Ainle, Fionnuala; McCallion, Naomi