日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype

p62结合的丧失导致TIF-IA在衰老过程中积累,进而促进核仁的表型改变以及衰老相关分泌表型的形成。

Thoms, Hazel C; Brant, Tyler S; Duckett, Katie; Yang, Yizheng; Dong, Jinxi; Wang, Hongfei; Derby, Freya; Akeke, Oluwatumilara F; Al-Alayeen, Faizah; Newell, Amy; Manasterski, Piotr; Gopalakrishnan, Aishwarya; Mann, Derek; Millar, Fraser R; Von Kriegsheim, Alex; Acosta, Juan Carlos; Oakley, Fiona; Stark, Lesley A

Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways

内皮细胞 c-REL 通过与 TXNIP-p38 和非经典 NF-κB 通路的相互作用,在血流紊乱区域调控动脉粥样硬化。

Tardajos Ayllon, Blanca; Bowden, Neil; Souilhol, Celine; Darwish, Hazem; Tian, Siyu; Duckworth, Carrie; Pritchard, David Mark; Xu, Suowen; Sayers, Jon; Francis, Sheila; Serbanovic-Canic, Jovana; Oakley, Fiona; Evans, Paul Charles

Precision-cut tumor slices for modeling hepatocellular carcinoma enable at-scale drug screening.

精确切割的肿瘤切片可用于模拟肝细胞癌,从而实现大规模药物筛选

Collins Amy L, Kirkness Keara, Ramon-Gil Erik, Tzortzopoulou Eleni, Geh Daniel, Dishington Jack, Graham Eleanor, Muir Rhys, Cameron Rainie, Luli Saimir, Khurram Eman, Storey Daniel, Paish Hannah L, Nelson Glyn, McDonald David, Filby Andrew, Borthwick Lee A, Oakley Fiona, Mann Derek A, Leslie Jack

Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitors.

利用新型 HDAC6 抑制剂进行肝纤维化进展的药理学调控

Borrello Maria Teresa, Ruzic Dusan, Paish Hannah, Graham Eleanor, Collins Amy L, Scott Rebecca, Higginbotham Sam, Radovic Branko, Nelson Glyn, Bulmer David, Borthwick Lee A, Robinson Stuart M, French Jeremy, Moir John, White Steve A, Wilson Colin, Pandanaboyana Sanjay, Hammond John, Thakkar Rohan, Alrawashdeh Wasfi, Figueiredo Rodrigo, Petkovic Milos, Nikolic Katarina, Oakley Fiona, Mann Derek A, Mann Jelena

Bioprinted High-Cell-Density Laminar Scaffolds Stimulate Extracellular Matrix Production in Osteochondral Co-Cultures.

生物打印高细胞密度层状支架刺激骨软骨共培养物中细胞外基质的产生

Bowes Aidan, Collins Amy, Oakley Fiona, Gentile Piergiorgio, Ferreira Ana Marina, Dalgarno Kenny

c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

c-Rel依赖的Chk2信号通路调控DNA损伤反应,从而限制肝癌的发生。

Leslie, Jack; Hunter, Jill E; Collins, Amy; Rushton, Amelia; Russell, Lauren G; Ramon-Gil, Erik; Laszczewska, Maja; McCain, Misti; Zaki, Marco Y W; Knox, Amber; Seow, Yixin; Sabater, Laura; Geh, Daniel; Perkins, Neil D; Reeves, Helen L; Tiniakos, Dina; Mann, Derek A; Oakley, Fiona

miRNA Expression in Fibroblastic Foci within Idiopathic Pulmonary Fibrosis Lungs Reveals Novel Disease-Relevant Pathways

特发性肺纤维化肺组织中成纤维细胞灶内 miRNA 表达揭示了与疾病相关的新通路

Sabater, Laura; Gossart, Jean B; Hernandez, Inmaculada; Rico, Daniel; Blanchard, Andy; Borthwick, Lee A; Fisher, Andrew J; Majo, Joaquim; Jiwa, Kasim; Collins, Amy; Abbate, Giuseppe; Oakley, Fiona; Mann, Derek A; Mann, Jelena

Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?

来自癌症相关成纤维细胞的硫酸酯酶-2:肝细胞癌的环境靶点?

Zaki, Marco Y W; Alhasan, Sari F; Shukla, Ruchi; McCain, Misti; Laszczewska, Maja; Geh, Daniel; Patman, Gillian L; Televantou, Despina; Whitehead, Anna; Maurício, João P; Barksby, Ben; Gee, Lucy M; Paish, Hannah L; Leslie, Jack; Younes, Ramy; Burt, Alastair D; Borthwick, Lee A; Thomas, Huw; Beale, Gary S; Govaere, Olivier; Sia, Daniela; Anstee, Quentin M; Tiniakos, Dina; Oakley, Fiona; Reeves, Helen L

Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression

肝细胞衰老在肝星状细胞活化和肝纤维化进展中的作用

Wijayasiri, Pramudi; Astbury, Stuart; Kaye, Philip; Oakley, Fiona; Alexander, Graeme J; Kendall, Timothy J; Aravinthan, Aloysious D

Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression

抑制胰岛素诱导基因1 (INSIG1) 的功能可促进肝脏脂质重塑并抑制非酒精性脂肪性肝炎 (NASH) 的进展。

Azzu, Vian; Vacca, Michele; Kamzolas, Ioannis; Hall, Zoe; Leslie, Jack; Carobbio, Stefania; Virtue, Samuel; Davies, Susan E; Lukasik, Agnes; Dale, Martin; Bohlooly-Y, Mohammad; Acharjee, Animesh; Lindén, Daniel; Bidault, Guillaume; Petsalaki, Evangelia; Griffin, Julian L; Oakley, Fiona; Allison, Michael E D; Vidal-Puig, Antonio