日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Hair-follicle-associated pluripotent (HAP) stem-cell-sheet implantation accelerates cutaneous wound closure and suppresses scar formation in a mouse model.

毛囊相关多能干细胞(HAP)片移植可加速小鼠模型皮肤伤口愈合并抑制疤痕形成

Obara Koya, Baba Kyoko, Shirai Kyoumi, Hamada Yuko, Arakawa Nobuko, Hasegawa Ayami, Takaoka Nanako, Aki Ryoichi, Hoffman Robert M

Engineered Methioninase-expressing Tumor-targeting Salmonella typhimurium A1-R Inhibits Syngeneic-Cancer Mouse Models by Depleting Tumor Methionine

经基因工程改造表达甲硫氨酸酶的肿瘤靶向鼠伤寒沙门氏菌A1-R通过消耗肿瘤甲硫氨酸抑制同源癌症小鼠模型

Kubota, Yutaro; Zhao, Ming; Han, Qinghong; Aoki, Yusuke; Masaki, Noriyuki; Obara, Koya; Morinaga, Sei; Mizuta, Kohei; Sato, Motokazu; Bouvet, Michael; Kubota, Koichi; Tsunoda, Takuya; Hoffman, Robert M

Precise Non-invasive Imaging Mouse Model of Pancreatic Cancer: Very Narrow Band-width Laser Fluorescence Excitation of Green Fluorescent Protein Provides Ultra-bright Tumor Images With no Skin Autofluorescence

胰腺癌精准无创成像小鼠模型:利用极窄带宽激光荧光激发绿色荧光蛋白,可获得超亮肿瘤图像,且无皮肤自发荧光干扰

Kubota, Yutaro; Wang, April; Chang, Neil; Tarantino, Samantha; Gallagher, Sean; Aoki, Yusuke; Masaki, Noriyuki; Obara, Koya; Morinaga, Sei; Tsunoda, Takuya; Hoffman, Robert M

Superiority of [(11)C]methionine over [(18)F]deoxyglucose for PET Imaging of Multiple Cancer Types Due to the Methionine Addiction of Cancer

由于癌症对蛋氨酸的依赖性,[(11)C]蛋氨酸在多种癌症类型的PET成像中优于[(18)F]脱氧葡萄糖。

Kubota, Yutaro; Sato, Toshihiko; Hozumi, Chihiro; Han, Qinghong; Aoki, Yusuke; Masaki, Noriyuki; Obara, Koya; Tsunoda, Takuya; Hoffman, Robert M

Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice

在C57BL/6小鼠中,通过缺乏蛋氨酸的饮食或口服重组产蛋氨酸酶的大肠杆菌可逆转老年性肥胖。

Kubota, Yutaro; Han, Qinghong; Reynoso, Jose; Aoki, Yusuke; Masaki, Noriyuki; Obara, Koya; Hamada, Kazuyuki; Bouvet, Michael; Tsunoda, Takuya; Hoffman, Robert M

The Combination of Methioninase and Ethionine Exploits Methionine Addiction to Selectively Eradicate Osteosarcoma Cells and Not Normal Cells and Synergistically Down-regulates the Expression of C-MYC.

甲硫氨酸酶和乙硫氨酸的结合利用甲硫氨酸的依赖性选择性地根除骨肉瘤细胞,而不影响正常细胞,并协同下调 C-MYC 的表达

Aoki Yusuke, Kubota Yutaro, Han Qinghong, Masaki Noriyuki, Obara Koya, Bouvet Michael, Chawla Sant P, Tome Yasunori, Nishida Kotaro, Hoffman Robert M

Oncogenes and Methionine Addiction of Cancer: Role of c-MYC.

癌基因与蛋氨酸成瘾:c-MYC 的作用

Aoki Yusuke, Han Qinghong, Kubota Yutaro, Masaki Noriyuki, Obara Koya, Tome Yasunori, Bouvet Michael, Nishida Kotaro, Hoffman Robert M

Meckel's Diverticulum Carcinoma Is Arrested by Oxaliplatinum and Eradicated by 5-Fluorouracil in a PDX Mouse Model Indicating Candidate First-line Treatment for a Rare Cancer

在PDX小鼠模型中,奥沙利铂可抑制梅克尔憩室癌的进展,而5-氟尿嘧啶可根除该癌,这表明其可能成为一种罕见癌症的一线治疗方案。

Masaki, Noriyuki; Yonemura, Yutaka; Hozumi, Chihiro; Obara, Koya; Kubota, Yutaro; Aoki, Yusuke; Hoffman, Robert M

Precise and Facile Endotracheal Lung-tumor-implantation Mouse Model Visualized by GFP Expression

通过GFP表达可视化的精确简便的气管内肺肿瘤移植小鼠模型

Aoki, Yusuke; Kobayashi, Keita J; Varshney, Nundini; Kubota, Yutaro; Masaki, Noriyuki; Obara, Koya; Wang, Justin D; Tome, Yasunori; Bouvet, Michael; Nishida, Kotaro; Hoffman, Robert M

Synergy of Combining Methionine Restriction and Chemotherapy: The Disruptive Next Generation of Cancer Treatment

蛋氨酸限制疗法与化疗的协同作用:颠覆性的下一代癌症治疗

Kubota, Yutaro; Han, Qinghong; Aoki, Yusuke; Masaki, Noriyuki; Obara, Koya; Hamada, Kazuyuki; Hozumi, Chihiro; Wong, Andrew C W; Bouvet, Michael; Tsunoda, Takuya; Hoffman, Robert M