日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic

脑 P450 环氧合酶活性是非阿片类镇痛药 improgan 发挥抗伤害作用所必需的

Lindsay B Hough, Julia W Nalwalk, Jun Yang, Jennie L Conroy, Melissa A VanAlstine, Weizhu Yang, Joseph Gargano, Zhixing Shan, Shao-Zhong Zhang, Mark P Wentland, James G Phillips, Brian I Knapp, Jean M Bidlack, Obbe P Zuiderveld, Rob Leurs, Xinxin Ding

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A

片段库筛选揭示了G蛋白偶联受体组胺H₄与离子通道血清素5-HT₃A之间存在显著的相似性。

Verheij, Mark H P; de Graaf, Chris; de Kloe, Gerdien E; Nijmeijer, Saskia; Vischer, Henry F; Smits, Rogier A; Zuiderveld, Obbe P; Hulscher, Saskia; Silvestri, Linda; Thompson, Andrew J; van Muijlwijk-Koezen, Jacqueline E; Lummis, Sarah C R; Leurs, Rob; de Esch, Iwan J P

Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling

阿片类药物通过细胞色素P450/环氧酶信号通路激活大脑镇痛回路。

Conroy, Jennie L; Fang, Cheng; Gu, Jun; Zeitlin, Scott O; Yang, Weizhu; Yang, Jun; VanAlstine, Melissa A; Nalwalk, Julia W; Albrecht, Phillip J; Mazurkiewicz, Joseph E; Snyder-Keller, Abigail; Shan, Zhixing; Zhang, Shao-Zhong; Wentland, Mark P; Behr, Melissa; Knapp, Brian I; Bidlack, Jean M; Zuiderveld, Obbe P; Leurs, Rob; Ding, Xinxin; Hough, Lindsay B