日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

曲妥珠单抗下铰链区内的单个蛋白水解切割会降低免疫效应功能和体内疗效

Fan Xuejun, Brezski Randall J, Fa Ming, Deng Hui, Oberholtzer Allison, Gonzalez Anneliese, Dubinsky William P, Strohl William R, Jordan Robert E, Zhang Ningyan, An Zhiqiang

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

肿瘤相关蛋白酶和微生物蛋白酶通过在铰链区附近的一次切割,破坏宿主IgG效应功能。

Brezski, Randall J; Vafa, Omid; Petrone, Diane; Tam, Susan H; Powers, Gordon; Ryan, Mary H; Luongo, Jennifer L; Oberholtzer, Allison; Knight, David M; Jordan, Robert E