日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Regulation of Duplex Formation in Response to pH and Complementary RNA: Development of Oligonucleotides Modified with S‑Methylthioimidate-Bridged Nucleic Acid and Evaluation of Their Function

pH值和互补RNA对双链形成调控的研究：S-甲基硫代亚胺桥联核酸修饰寡核苷酸的开发及其功能评价

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.5c10817
Osawa, Takashi; Miyata, Kosuke; Ito, Sayoko; Uda, Keito; Obika, Satoshi
信号转导
发表日期：2026
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Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses.

针对 GBF1 的反义寡核苷酸对 SARS-CoV-2 和流感病毒具有广谱抗病毒活性。

期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2026.114851
Simanihuruk Victoria, Kida Yurie, Takada Kosuke, Yamaguma Harumi, Kameoka Natsumi, Anzai Itsuki, Shichinohe Shintaro, Obika Satoshi, Kasahara Yuuya, Watanabe Tokiko
流感
GBF1
SARS-CoV-2
发表日期：2026
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Genetic Encoding of a Trifunctional Photo-Cross-Linker with a Cleavable Alkyl Ester Moiety

具有可裂解烷基酯部分的三功能光交联剂的基因编码

期刊:Chembiochem
影响因子:2.8
doi:10.1002/cbic.202500827
Takayama, Masahiro; Tsubota, Tomoya; Yamaguchi, Takao; Chiba, Kosuke; Yoshida, Takumi; Hari, Yoshiyuki; Tian, Yu-Shi; Takaya, Daisuke; Mori, Asuka; Tsukamoto, Tomohito; Ishimoto, Kenji; Ago, Yukio; Okada, Yoshiaki; Sakamoto, Kensaku; Doi, Takefumi; Fukuzawa, Kaori; Obika, Satoshi; Nakagawa, Shinsaku; Hino, Nobumasa
发表日期：2026
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Cycloalkane Incorporation Into the 2',4'-Bridge of Locked Nucleic Acid: Enhancing Nuclease Stability, Reducing Phosphorothioate Modifications, and Lowering Hepatotoxicity in Antisense Oligonucleotides

环烷烃掺入锁定核酸的2',4'-桥：增强核酸酶稳定性，减少硫代磷酸酯修饰，降低反义寡核苷酸的肝毒性

期刊:JACS Au
影响因子:8.7
doi:10.1021/jacsau.5c01005
Yamaguchi, Takao; Komine, Hibiki; Sugiura, Takaya; Kumagai, Riku; Yoshida, Tokuyuki; Sasaki, Kiyomi; Nakayama, Taisuke; Kamada, Haruhiko; Inoue, Takao; Obika, Satoshi
毒理研究
发表日期：2025
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MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration.

抑制MicroRNA-33可增强骨骼肌再生，从而改善肌肉萎缩症

期刊:EMBO Molecular Medicine
影响因子:8.3
doi:10.1038/s44321-025-00273-9
Sowa Naoya, Horie Takahiro, Ide Yuya, Baba Osamu, Kora Kengo, Yoshida Takeshi, Nakamura Yujiro, Matsumura Shigenobu, Matsushita Kazuki, Imanaka Miyako, Zou Fuquan, Kume Eitaro, Kojima Hidenori, Qian Qiuxian, Kimura Kayo, Otsuka Ryotaro, Hara Noriko, Yamasaki Tomohiro, Otani Chiharu, Tsujisaka Yuta, Takaya Tomohide, Nishimura Chika, Watanabe Dai, Hasegawa Koji, Kotera Jun, Oka Kozo, Fujita Ryo, Takemiya Akihiro, Sasaki Takashi, Kasahara Yuuya, Obika Satoshi, Kimura Takeshi, Ono Koh
骨科研究
发表日期：2025
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Rupatadine suppresses tumor growth and EMT in pancreatic cancer: Evidence from in vitro and in vivo models

卢帕他定抑制胰腺癌的肿瘤生长和上皮间质转化：来自体外和体内模型的证据

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-024-02859-5
Kanda, Mitsuro; Kasahara, Yuuya; Shimizu, Dai; Shinozuka, Takahiro; Sasahara, Masahiro; Nakamura, Shunsuke; Iguchi, Yohei; Katsuno, Masahisa; Kodera, Yasuhiro; Obika, Satoshi; Choi, Byung Jo; Choi, Ho Joong; Lee, Dosang; Park, Jung Hyun; Hong, Tae Ho; Jung, Hee-Jung; Jo, Ga-Hee; Kim, Ok-Hee; Kim, Say-June
胰腺癌
肿瘤
肿瘤免疫
上皮间质转化
发表日期：2025
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Effect of chemical modification on the exon-skipping activity of heteroduplex oligonucleotides

化学修饰对外显子跳跃活性的影响

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.5
doi:10.1016/j.omtn.2025.102468
Takenori Shimo, Juri Hasegawa, Kotaro Yoshioka, Yusuke Nakatsuji, Kotomi Aso, Keisuke Tachibana, Tetsuya Nagata, Takanori Yokota, Satoshi Obika
表观遗传
发表日期：2025
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Antisense oligonucleotide targeting the E3 ligase RFFL potentiates CFTR modulator efficacy in CF primary bronchial epithelial cells

靶向E3连接酶RFFL的反义寡核苷酸可增强CFTR调节剂在CF原代支气管上皮细胞中的疗效

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102756
Hinata, Daichi; Kai, Yukari; Fukuda, Ryosuke; Kamada, Yuka; Kasahara, Yuuya; Sasaki, Kiyomi; Yoshida, Tokuyuki; Obika, Satoshi; Inoue, Takao; Okiyoneda, Tsukasa
上皮细胞
CFTR
细胞生物学
发表日期：2025
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Unraveling and controlling late-onset neurotoxicity of antisense oligonucleotides through strategic chemical modifications

通过策略性化学修饰揭示和控制反义寡核苷酸的迟发性神经毒性

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102692
Kuroda, Takayuki; Yoshioka, Kotaro; Mon, Su Su Lei; Katsuyama, Maho; Sato, Kumiko; Isogai, Eriko; Yoshida-Tanaka, Kie; Iwata-Hara, Rintaro; Yamaguchi, Takao; Obika, Satoshi; Yokota, Takanori
毒理研究
发表日期：2025
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Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects

靶向烟酰胺N-甲基转移酶的反义寡核苷酸具有抗肿瘤作用

期刊:Molecular Therapy-Nucleic Acids
影响因子:6.1
doi:10.1016/j.omtn.2025.102548
Hara, Tomoaki; Meng, Sikun; Kasahara, Yuuya; Osawa, Takashi; Motooka, Daisuke; Sato, Hiromichi; Arao, Yasuko; Saito, Yoshiko; Inoue, Kana; Hamano, Yumiko; Doki, Yuichiro; Eguchi, Hidetoshi; Obika, Satoshi; Ishii, Hideshi
肿瘤
肿瘤免疫
发表日期：2025
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