日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

From consortia discovery to biotech creation: An innovative approach to next-gen Alzheimer's drugs

从联盟发现到生物技术创造:下一代阿尔茨海默病药物的创新方法

Giardina, Sarah F; Culver, Alexander; Ahmed, Chandrama; Mirescu, Christian; Oblak, Adrian L; Brosch, Jared; Clayton, W Brent; Dage, Jeffrey L; Lamb, Bruce T; Richardson, Timothy I; Small, Derek; Palkowitz, Alan D

Müller Glial Kir4.1 Channel Dysfunction in APOE4-KI Model of Alzheimer's Disease

阿尔茨海默病APOE4-KI模型中Müller胶质细胞Kir4.1通道功能障碍

Abhyankar, Surabhi D; Xiao, Yucheng; Mahajan, Neha; Luo, Qianyi; Cummins, Theodore R; Oblak, Adrian L; Lamb, Bruce T; Corson, Timothy W; Bhatwadekar, Ashay D

High-fat Western diet induces retinal and metabolic alterations in APOE3 and APOE4 knock-in mice

高脂西式饮食可诱导APOE3和APOE4基因敲入小鼠的视网膜和代谢改变。

Abhyankar, Surabhi D; Luo, Qianyi; Hartman, Gabriella D; Mahajan, Neha; Corson, Timothy W; Oblak, Adrian L; Lamb, Bruce T; Bhatwadekar, Ashay D

Optimization and Characterization of SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease Models.

SHIP1 配体的优化和表征及其在阿尔茨海默病模型中的细胞靶点结合和活性。

Jesudason Cynthia D, Rangel-Barajas Claudia, Beach Colin J, Beck Daniel E, Caballero-Floran Isaac H, Clayton W Brent, Da Silva Lais, David Juliane C, Doolen Suzanne, Faulkner Alexandra N, Hamdani Adam K, Huhe Hasi, Huynh Kevin, Imhoff Ryan D, Javens-Wolfe June, Mason Emily R, Moussaif Mustapha, Singhal Kratika, Soni Disha M, van Buuren-Milne Matilda, Williams Sean-Paul, Angus Steven P, Chu Shaoyou, Dage Jeffrey L, Hipskind Philip A, Johnson Travis S, Kaddurah-Daouk Rima, Lamb Bruce T, Meikle Peter J, Mesecar Andrew D, Palkowitz Alan D, Quinney Sara K, Sukoff Rizzo Stacey J, Oblak Adrian L, Richardson Timothy I

Multi‐Omics analysis identifies that different genetic perturbations affect various molecular mechanisms underlying Alzheimer's Disease (AD) in an age‐dependent manner

多组学分析表明,不同的基因扰动会以年龄依赖的方式影响阿尔茨海默病(AD)的各种分子机制。

Curtis, David; Joseph, Shujaani; Xiao, Xuewen; Liao, Xinxin; Liu, Yiliang; Luo, Shilin; Tang, Beisha; Li, Jinchen; Jiao, Bin; Shen, Lu; Akinyemi, Rufus O; Rajabli, Farid; Consortium, African Dementia; Griswold, Anthony J; Badillo, Vanessa M Colón; Reddy, Joseph S; Jin, Jiangli; Lincoln, Sarah J; Ho, Charlotte CG; Crook, Julia E; Wang, Xue; Malphrus, Kimberly G; Nguyen, Thuy T; Kuchenbecker, Lindsey A; Polanco, Jean M Marrero; Tamvaka, Nicole; Lachner, Christian; Day, Gregory S; Lucas, John A; Graff‐Radford, Neill R; Ertekin‐Taner, Nilüfer; Carrasquillo, Minerva M; Scott, Kyle M; Rajabli, Farid; Akinyemi, Joshua O; Adams, Larry D; Coker, Motunrayo; Akinwande, Kazeem; Diala, Samuel; Whitehead, Patrice G; Ogunronbi, Mayowa; Hamilton‐Nelson, Kara L; Damasceno, Albertino; Zaman, Andrew F; Zewde, Yared Z; Ayele, Biniyam A; Caban‐Holt, Allison M; Ndetei, David; Griswold, Anthony J; Sarfo, Fred Stephen; Blanton, Susan H; Akpalu, Albert; Cuccaro, Michael L; Wahab, Kolawole; McInerney, Katalina F; Obiako, Reginald; Baiyewu, Olusegun; Mena, Pedro R; Okubadejo, Njideka U; Owolabi, Mayowa O; Chavez, Jenny; Martinez, Izri M; Kunkle, Brian W; Vance, Jeffery M; Reitz, Christiane; Tosto, Giuseppe; Williams, Scott M; Bush, William S; Kalaria, Raj; Haines, Jonathan L; Ogunniyi, Adesola; Byrd, Goldie S; Akinyemi, Rufus O; Pericak‐Vance, Margaret; Pandey, Ravi S; Kotredes, Kevin P; Garceau, Dylan; Spruce, Catrina; Shantaraman, Anantharaman; Duong, Duc M; Paisie, Carolyn; Seyfried, Nicholas T; Rangel‐Barajas, Claudia; Sasner, Michael; Oblak, Adrian L; Howell, Gareth R; Lamb, Bruce T; Carter, Gregory W

Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease.

APOE4 基因敲入小鼠阿尔茨海默病模型中的视网膜功能障碍

Abhyankar Surabhi D, Luo Qianyi, Hartman Gabriella D, Mahajan Neha, Corson Timothy W, Oblak Adrian L, Lamb Bruce T, Bhatwadekar Ashay D

Detecting Beta-amyloid Plaque via Low Rank Based Orthogonal Projection and Spatial-spectrum Detector Using High-resolution Quantitative Susceptibility Mapping for Preclinical Studies

利用高分辨率定量磁化率成像技术,通过低秩正交投影和空间谱检测器检测β-淀粉样蛋白斑块,用于临床前研究

Chen, Jie; Han, Xinyue; Liu, Zhuoheng; Zhou, Chengqian; Hu, Rui; Tabassam, Saira; Wyatt-Johnson, Season K; Oblak, Adrian L; Brutkiewicz, Randy R; Lin, Mingquan; Wang, Nian

Multi‐Omics analysis identifies that different genetic perturbations affect various molecular mechanisms underlying Alzheimer's Disease (AD) in an age‐dependent manner

多组学分析表明,不同的基因扰动会以年龄依赖的方式影响阿尔茨海默病(AD)的各种分子机制。

Miki, Takafumi; Pandey, Ravi S; Kotredes, Kevin P; Garceau, Dylan; Spruce, Catrina; Shantaraman, Anantharaman; Duong, Duc M; Paisie, Carolyn; Seyfried, Nicholas T; Rangel‐Barajas, Claudia; Sasner, Michael; Oblak, Adrian L; Howell, Gareth R; Lamb, Bruce T; Carter, Gregory W

A1527G variant of ABCA7 increases soluble and insoluble Aβ40‐42 in an animal model for late‐onset Alzheimer's disease

ABCA7 的 A1527G 变体在晚发性阿尔茨海默病动物模型中增加可溶性和不溶性 Aβ40-42

Sampath, Nishanth; Raghavendra, Sunil Kapilavayi; Ratha, Vishwaraj; Sivakumar, Gomathi; Sankaran, Vijay; Suresh Bapu, K R; Bernabe, Cristian S; Kotredes, Kevin P; Pandey, Ravi S; Carter, Gregory W; Sasner, Michael; Oblak, Adrian L; Howell, Gareth R; Lamb, Bruce T; Territo, Paul R

Pulmonary Hypertension Promotes Neuroinflammation and Neurodegeneration

肺动脉高压促进神经炎症和神经退行性变

De La Cruz, Priscilla M; Lockett, Angelia; Gomes, Marta T; Banerjee, Somanshu; Razee, Asif; Fisher, Amanda; Cook, Todd; Lloyd, Christopher D; Magaki, Shino; Umar, Soban; Oblak, Adrian L; Machado, Roberto F