Obsil相关文献与解析，生知库 | 链接生命科学的每一步

Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins

泛素连接酶Nedd4-2自身抑制的结构基础及其受钙和14-3-3蛋白的调控

Janosev, Masa; Kosek, Dalibor; Tekel, Andrej; Joshi, Rohit; Honzejkova, Karolina; Pohl, Pavel; Obsil, Tomas; Obsilova, Veronika

信号转导

发表日期：2025

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The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

ASK1的冷冻电镜结构揭示了一种受TRX1变构调节的不对称结构。

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.95199

Honzejkova, Karolina; Kosek, Dalibor; Obsilova, Veronika; Obsil, Tomas

TRX

发表日期：2024

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Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins

寻找支架：14-3-3蛋白对酶活性的多方面调控

期刊:Physiological Research

影响因子:2

doi:10.33549/physiolres.935306

Obsilova, V; Obsil, T

信号转导

发表日期：2024

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14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices

14-3-3蛋白通过其C端最后两个螺旋阻断激酶活性位点来抑制CaMKK1。

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.4805

Petrvalska, Olivia; Honzejkova, Karolina; Koupilova, Nicola; Herman, Petr; Obsilova, Veronika; Obsil, Tomas

信号转导

发表日期：2023

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FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA

FOXO4 与 p53 的 TAD 和 CRD 相互作用，并抑制其与 DNA 的结合。

期刊:Protein Science

影响因子:5.2

doi:10.1002/pro.4287

Mandal, Raju; Kohoutova, Klara; Petrvalska, Olivia; Horvath, Matej; Srb, Pavel; Veverka, Vaclav; Obsilova, Veronika; Obsil, Tomas

FOXO4

发表日期：2022

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Lengthening the Guanidine-Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription

延长苯基嘧啶胍的胍-芳基连接体可增强其作为 FOXO3 诱导基因转录抑制剂的效力

期刊:ACS Omega

影响因子:3.7

doi:10.1021/acsomega.2c04613

Klara Kohoutova, Vojtěch Dočekal, Michael J Ausserlechner, Nora Kaiser, Andrej Tekel, Raju Mandal, Matej Horvath, Veronika Obsilova, Jan Vesely, Judith Hagenbuchner, Tomas Obsil

信号转导

发表日期：2022

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Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains

Nedd4-2 与 14-3-3 的结合调节其催化位点和 WW 结构域的可及性

期刊:Biophysical Journal

影响因子:3.1

doi:10.1016/j.bpj.2022.02.025

Joshi, Rohit; Pohl, Pavel; Strachotova, Dita; Herman, Petr; Obsil, Tomas; Obsilova, Veronika

发表日期：2022

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14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

14-3-3蛋白通过调节HECT和WW结构域之间的相互作用来调控Nedd4-2。

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-021-02419-0

Pohl, Pavel; Joshi, Rohit; Petrvalska, Olivia; Obsil, Tomas; Obsilova, Veronika

信号转导

发表日期：2021

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14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites

14-3-3蛋白通过促进DAPK2二聚化和保护关键调控磷酸化位点来使其失活。

期刊:Communications Biology

影响因子:5.1

doi:10.1038/s42003-021-02518-y

Horvath, Matej; Petrvalska, Olivia; Herman, Petr; Obsilova, Veronika; Obsil, Tomas

Structural plasticity of the FOXO-DBD:p53-TAD interaction

FOXO-DBD:p53-TAD相互作用的结构可塑性

Structural basis of ubiquitin ligase Nedd4-2 autoinhibition and regulation by calcium and 14-3-3 proteins

泛素连接酶Nedd4-2自身抑制的结构基础及其受钙和14-3-3蛋白的调控

The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

ASK1的冷冻电镜结构揭示了一种受TRX1变构调节的不对称结构。

Look for the Scaffold: Multifaceted Regulation of Enzyme Activity by 14-3-3 Proteins

寻找支架：14-3-3蛋白对酶活性的多方面调控

14-3-3 protein inhibits CaMKK1 by blocking the kinase active site with its last two C-terminal helices

14-3-3蛋白通过其C端最后两个螺旋阻断激酶活性位点来抑制CaMKK1。

FOXO4 interacts with p53 TAD and CRD and inhibits its binding to DNA

FOXO4 与 p53 的 TAD 和 CRD 相互作用，并抑制其与 DNA 的结合。

Lengthening the Guanidine-Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription

延长苯基嘧啶胍的胍-芳基连接体可增强其作为 FOXO3 诱导基因转录抑制剂的效力

Nedd4-2 binding to 14-3-3 modulates the accessibility of its catalytic site and WW domains

Nedd4-2 与 14-3-3 的结合调节其催化位点和 WW 结构域的可及性

14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains

14-3-3蛋白通过调节HECT和WW结构域之间的相互作用来调控Nedd4-2。

14-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites

14-3-3蛋白通过促进DAPK2二聚化和保护关键调控磷酸化位点来使其失活。