日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety and efficacy of CRS3123 in adults with a primary episode or first recurrence of Clostridioides difficile infection: a phase 2, randomised, double-blind, multicentre, vancomycin-controlled study

CRS3123治疗成人首次感染或复发性艰难梭菌感染的安全性和有效性:一项II期随机、双盲、多中心、万古霉素对照研究

Louie, Thomas; Ribble, Wendy; Boccumini, Louis; Johnson, Katherine; De Groote, Mary A; Day, Joshua; Mason, Clifford; Sun, Xicheng; Freeman, Jane; Gu, Kenan; Tillotson, Glenn; Wilcox, Mark H; Janjic, Nebojsa; Jarvis, Thale C; Nayak, Seema U; Ochsner, Urs A; Bruss, Jon B

Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.

CRS0393 是一种新型抗分枝杆菌药物,靶向 MmpL3,其微生物学特征、临床前药代动力学和疗效研究

Ochsner Urs A, De Groote Mary A, Jarvis Thale C, Liu Hang, Youmans Tessa, Hoang Teresa, Ribble Wendy, Day Joshua, Li Wei, Pearce Camron, Walz Amanda, Panthi Chandra M, Rimal Binayak, Stevens Casey M, Zgurskaya Helen I, Jackson Mary, Ordway Diane, Gonzalez-Juarrero Mercedes, Sun Xicheng, Lamichhane Gyanu, Mason Clifford

Potency of the novel PolC DNA polymerase inhibitor CRS0540 in a disseminated Listeria monocytogenes intracellular hollow-fibre model

新型PolC DNA聚合酶抑制剂CRS0540在播散性单核细胞增生李斯特菌细胞内空心纤维模型中的效力

Patel, Swati; Chapagain, Moti; Mason, Clifford; Gingrich, Matthew; Athale, Shruti; Ribble, Wendy; Hoang, Teresa; Day, Joshua; Sun, Xicheng; Jarvis, Thale; Ochsner, Urs A; Howe, David; Gumbo, Tawanda

Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection

利用高通量蛋白质组学分析Quantiferon上清液,鉴定潜伏性结核感染的生物标志物

De Groote, Mary Ann; Higgins, Michael; Hraha, Thomas; Wall, Kirsten; Wilson, Michael L; Sterling, David G; Janjic, Nebojsa; Reves, Randall; Ochsner, Urs A; Belknap, Robert

Correction for De Groote et al., "Highly Multiplexed Proteomic Analysis of Quantiferon Supernatants To Identify Biomarkers of Latent Tuberculosis Infection"

对 De Groote 等人的论文“利用 QuantiFERON 上清液进行高通量蛋白质组学分析以鉴定潜伏性结核感染的生物标志物”的更正

De Groote, Mary Ann; Higgins, Michael; Hraha, Thomas; Wall, Kirsten; Wilson, Michael L; Sterling, David G; Janjic, Nebojsa; Reves, Randall; Ochsner, Urs A; Belknap, Robert

Discovery and Validation of a Six-Marker Serum Protein Signature for the Diagnosis of Active Pulmonary Tuberculosis

发现并验证用于诊断活动性肺结核的六种血清蛋白标志物

De Groote, Mary A; Sterling, David G; Hraha, Thomas; Russell, Theresa M; Green, Louis S; Wall, Kirsten; Kraemer, Stephan; Ostroff, Rachel; Janjic, Nebojsa; Ochsner, Urs A

Safety, Tolerability, Systemic Exposure, and Metabolism of CRS3123, a Methionyl-tRNA Synthetase Inhibitor Developed for Treatment of Clostridium difficile, in a Phase 1 Study

在一项 1 期研究中,评估了 CRS3123(一种用于治疗艰难梭菌感染的甲硫氨酰-tRNA 合成酶抑制剂)的安全性、耐受性、全身暴露量和代谢情况。

Nayak, Seema U; Griffiss, J McLeod; Blumer, Jeffrey; O'Riordan, Mary Ann; Gray, Wesley; McKenzie, Robin; Jurao, Robert A; An, Amanda T; Le, Melissa; Bell, Stacie J; Ochsner, Urs A; Jarvis, Thale C; Janjic, Nebojsa; Zenilman, Jonathan M

Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

具有类蛋白侧链的核酸配体:修饰适体及其在诊断和治疗中的应用

Rohloff, John C; Gelinas, Amy D; Jarvis, Thale C; Ochsner, Urs A; Schneider, Daniel J; Gold, Larry; Janjic, Nebojsa

Aptamer-based proteomic signature of intensive phase treatment response in pulmonary tuberculosis

基于适体的肺结核强化期治疗反应蛋白质组学特征

Nahid, Payam; Bliven-Sizemore, Erin; Jarlsberg, Leah G; De Groote, Mary A; Johnson, John L; Muzanyi, Grace; Engle, Melissa; Weiner, Marc; Janjic, Nebojsa; Sterling, David G; Ochsner, Urs A

Elucidating novel serum biomarkers associated with pulmonary tuberculosis treatment

阐明与肺结核治疗相关的新型血清生物标志物

De Groote, Mary A; Nahid, Payam; Jarlsberg, Leah; Johnson, John L; Weiner, Marc; Muzanyi, Grace; Janjic, Nebojsa; Sterling, David G; Ochsner, Urs A