日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

不同的 α-突触核蛋白朊病毒株可导致路易体痴呆和多系统萎缩

Jacob I Ayers, Joanne Lee, Octovia Monteiro, Amanda L Woerman, Ann A Lazar, Carlo Condello, Nick A Paras, Stanley B Prusiner

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

一种靶向溴结构域内非催化性、高度保守氨基酸残基的活性探针

D'Ascenzio, Melissa; Pugh, Kathryn M; Konietzny, Rebecca; Berridge, Georgina; Tallant, Cynthia; Hashem, Shaima; Monteiro, Octovia; Thomas, Jason R; Schirle, Markus; Knapp, Stefan; Marsden, Brian; Fedorov, Oleg; Bountra, Chas; Kessler, Benedikt M; Brennan, Paul E

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

MLLT1/3 YEATS结构域化学探针的发现

Moustakim, Moses; Christott, Thomas; Monteiro, Octovia P; Bennett, James; Giroud, Charline; Ward, Jennifer; Rogers, Catherine M; Smith, Paul; Panagakou, Ioanna; Díaz-Sáez, Laura; Felce, Suet Ling; Gamble, Vicki; Gileadi, Carina; Halidi, Nadia; Heidenreich, David; Chaikuad, Apirat; Knapp, Stefan; Huber, Kilian V M; Farnie, Gillian; Heer, Jag; Manevski, Nenad; Poda, Gennady; Al-Awar, Rima; Dixon, Darren J; Brennan, Paul E; Fedorov, Oleg

Discovery of a PCAF Bromodomain Chemical Probe

PCAF 溴结构域化学探针的发现

Moses Moustakim, Peter G K Clark, Laura Trulli, Angel L Fuentes de Arriba, Matthias T Ehebauer, Apirat Chaikuad, Emma J Murphy, Jacqui Mendez-Johnson, Danette Daniels, Chun-Feng D Hou, Yu-Hui Lin, John R Walker, Raymond Hui, Hongbing Yang, Lucy Dorrell, Catherine M Rogers, Octovia P Monteiro, Oleg F

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia

溴孢菌素对溴结构域的广泛靶向性表明 BET 蛋白是白血病中初级转录反应的主要调节剂

Sarah Picaud, Katharina Leonards, Jean-Philippe Lambert, Oliver Dovey, Christopher Wells, Oleg Fedorov, Octovia Monteiro, Takao Fujisawa, Chen-Yi Wang, Hannah Lingard, Cynthia Tallant, Nikzad Nikbin, Lucie Guetzoyan, Richard Ingham, Steven V Ley, Paul Brennan, Susanne Muller, Anastasia Samsonova, An

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain

一个预先构建的片段库能够实现快速合成扩展,从而获得了首批报道的非典型溴结构域 PHIP(2) 抑制剂。

Cox, Oakley B; Krojer, Tobias; Collins, Patrick; Monteiro, Octovia; Talon, Romain; Bradley, Anthony; Fedorov, Oleg; Amin, Jahangir; Marsden, Brian D; Spencer, John; von Delft, Frank; Brennan, Paul E

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

鉴定和开发靶向Switch/蔗糖非发酵复合物中溴结构域的2,3-二氢吡咯并[1,2-a]喹唑啉-5(1H)-酮抑制剂

Sutherell, Charlotte L; Tallant, Cynthia; Monteiro, Octovia P; Yapp, Clarence; Fuchs, Julian E; Fedorov, Oleg; Siejka, Paulina; Müller, Suzanne; Knapp, Stefan; Brenton, James D; Brennan, Paul E; Ley, Steven V

BET inhibition as a new strategy for the treatment of gastric cancer

BET抑制剂作为治疗胃癌的新策略

Montenegro, Raquel C; Clark, Peter G K; Howarth, Alison; Wan, Xiao; Ceroni, Alessandro; Siejka, Paulina; Nunez-Alonso, Graciela A; Monteiro, Octovia; Rogers, Catherine; Gamble, Vicki; Burbano, Rommel; Brennan, Paul E; Tallant, Cynthia; Ebner, Daniel; Fedorov, Oleg; O'Neill, Eric; Knapp, Stefan; Dixon, Darren; Müller, Susanne

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

开发一种选择性小分子抑制剂,靶向CBP/p300溴结构域,用于白血病治疗

Picaud, Sarah; Fedorov, Oleg; Thanasopoulou, Angeliki; Leonards, Katharina; Jones, Katherine; Meier, Julia; Olzscha, Heidi; Monteiro, Octovia; Martin, Sarah; Philpott, Martin; Tumber, Anthony; Filippakopoulos, Panagis; Yapp, Clarence; Wells, Christopher; Che, Ka Hing; Bannister, Andrew; Robson, Samuel; Kumar, Umesh; Parr, Nigel; Lee, Kevin; Lugo, Dave; Jeffrey, Philip; Taylor, Simon; Vecellio, Matteo L; Bountra, Chas; Brennan, Paul E; O'Mahony, Alison; Velichko, Sharlene; Müller, Susanne; Hay, Duncan; Daniels, Danette L; Urh, Marjeta; La Thangue, Nicholas B; Kouzarides, Tony; Prinjha, Rab; Schwaller, Jürg; Knapp, Stefan

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance

BRG/PB1 溴结构域的选择性靶向作用会损害胚胎和滋养层干细胞的维持

Oleg Fedorov, Josefina Castex, Cynthia Tallant, Dafydd R Owen, Sarah Martin, Matteo Aldeghi, Octovia Monteiro, Panagis Filippakopoulos, Sarah Picaud, John D Trzupek, Brian S Gerstenberger, Chas Bountra, Dominica Willmann, Christopher Wells, Martin Philpott, Catherine Rogers, Philip C Biggin, Paul E