日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Histone methyltransferase Setd8 preserves chromatin accessibility to safeguard retinal progenitor cell identity during development.

组蛋白甲基转移酶 Setd8 维持染色质的可及性，从而在发育过程中保护视网膜祖细胞的特性。

期刊:Stem Cell Reports
影响因子:5.1
doi:10.1016/j.stemcr.2025.102789
Sekiryu Haruka, Shimokawa Sakurako, Matsuda-Ito Kanae, Oda Hisanobu, Murakami Yusuke, Sonoda Koh-Hei, Nakashima Kinichi, Matsuda Taito
细胞生物学
发育与干细胞
发表日期：2026
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Predictors of prolonged progression-free survival in patients with unresectable or recurrent pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid (NAPOLEON-2 study)

纳米脂质体伊立替康联合氟尿嘧啶和亚叶酸治疗不可切除或复发性胰腺癌患者的无进展生存期延长预测因素（NAPOLEON-2 研究）

期刊:Therapeutic Advances in Medical Oncology
影响因子:4.2
doi:10.1177/17588359261442386
Kawaguchi, Yasunori; Hayashi, Kohei; Shimokawa, Mototsugu; Otsuka, Taiga; Nakazawa, Junichi; Shimokawa, Hozumi; Shinohara, Yudai; Koga, Futa; Oza, Noriko; Oda, Hisanobu; Takeshita, Shigeyuki; Arima, Shiho; Arita, Shuji; Nishikawa, Kazuo; Otsu, Satoshi; Taguchi, Hiroki; Jikuya, Kenichi; Sakai, Tatsunori; Ueda, Yujiro; Sakae, Takahiro; Araki, Norimasa; Sawase, Hironori; Ide, Yasushi; Kawahira, Machiko; Nio, Kenta; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
肿瘤免疫
肿瘤
胰腺癌
发表日期：2026
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Epigenetic regulation of neural stem cell aging in the mouse hippocampus by Setd8 downregulation.

Setd8下调对小鼠海马神经干细胞衰老进行表观遗传调控

期刊:EMBO Journal
影响因子:8.3
doi:10.1038/s44318-025-00455-8
Matsubara Shuzo, Matsuda-Ito Kanae, Sekiryu Haruka, Doi Hiroyoshi, Nakagawa Takumi, Murao Naoya, Oda Hisanobu, Nakashima Kinichi, Matsuda Taito
发育与干细胞
神经科学
细胞生物学
表观遗传
Hippo
Mouse
细胞衰老
发表日期：2025
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Comparison of inflammatory markers before and after nanoliposomal irinotecan and fluorouracil with folic acid in patients with pancreatic cancer: results from the NAPOLEON-2 study (NN-2302)

比较胰腺癌患者接受纳米脂质体伊立替康和氟尿嘧啶联合叶酸治疗前后炎症标志物的变化：NAPOLEON-2 研究 (NN-2302) 的结果

期刊:Therapeutic Advances in Medical Oncology
影响因子:4.2
doi:10.1177/17588359251320768
Araki, Tomonori; Hayashi, Kohei; Shimokawa, Mototsugu; Otsuka, Taiga; Sonoda, Yuki; Honda, Takuya; Shibuki, Taro; Nakazawa, Junichi; Arima, Shiho; Miwa, Keisuke; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Shimokawa, Hozumi; Takeshita, Shigeyuki; Nishikawa, Kazuo; Komori, Azusa; Otsu, Satoshi; Hosokawa, Ayumu; Sakai, Tatsunori; Oda, Hisanobu; Kawahira, Machiko; Arita, Shuji; Taguchi, Hiroki; Tsuneyoshi, Kengo; Fujita, Toshihiro; Sakae, Takahiro; Kawaguchi, Yasunori; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
肿瘤
炎症
肿瘤免疫
炎症/感染
胰腺癌
发表日期：2025
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Impact of prior chemotherapy on nanoliposomal irinotecan with fluorouracil and folinic acid for unresectable pancreatic cancer: a retrospective analysis of data from the multicenter NAPOLEON-2 study

既往化疗对纳米脂质体伊立替康联合氟尿嘧啶和亚叶酸治疗不可切除胰腺癌的影响：一项来自多中心 NAPOLEON-2 研究的回顾性数据分析

期刊:Therapeutic Advances in Medical Oncology
影响因子:4.2
doi:10.1177/17588359251393156
Koike, Tomomi; Kawaguchi, Yasunori; Shimokawa, Mototsugu; Otsuka, Taiga; Furukawa, Kanami; Shinohara, Yudai; Shimokawa, Hozumi; Yoshihiro, Tomoyasu; Shibuki, Taro; Nakazawa, Junichi; Arima, Shiho; Miwa, Keisuke; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Takeshita, Shigeyuki; Nishikawa, Kazuo; Komori, Azusa; Otsu, Satoshi; Hosokawa, Ayumu; Sakai, Tatsunori; Oda, Hisanobu; Kawahira, Machiko; Arita, Shuji; Honda, Takuya; Taguchi, Hiroki; Tsuneyoshi, Kengo; Fujita, Toshihiro; Sakae, Takahiro; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
胰腺癌
肿瘤
肿瘤免疫
发表日期：2025
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Relationship between neutropenia caused by nanoliposomal irinotecan/fluorouracil/leucovorin and treatment outcomes in the NAPOLEON-2 study (NN-2301)

NAPOLEON-2 研究 (NN-2301) 中纳米脂质体伊立替康/氟尿嘧啶/亚叶酸钙引起的中性粒细胞减少症与治疗结果的关系

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-88005-4
Araki, Tomonori; Sonoda, Yuki; Shimokawa, Mototsugu; Otsuka, Taiga; Hayashi, Kohei; Honda, Takuya; Nakao, Kazuhiko; Shibuki, Taro; Nakazawa, Junichi; Arima, Shiho; Miwa, Keisuke; Okabe, Yoshinobu; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Shimokawa, Hozumi; Takeshita, Shigeyuki; Komori, Azusa; Nishikawa, Kazuo; Otsu, Satoshi; Hosokawa, Ayumu; Oda, Hisanobu; Sakai, Tatsunori; Arita, Shuji; Kawahira, Machiko; Taguchi, Hiroki; Tsuneyoshi, Kengo; Kawaguchi, Yasunori; Fujita, Toshihiro; Sakae, Takahiro; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
细胞生物学
中性粒细胞
粒细胞
发表日期：2025
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Impact of biliary drainage for unresectable pancreatic cancer treated with nanoliposomal irinotecan with fluorouracil and folinic acid: retrospective results from the NAPOLEON-2 study

胆道引流对采用纳米脂质体伊立替康联合氟尿嘧啶和亚叶酸治疗的不可切除胰腺癌的影响：NAPOLEON-2 研究的回顾性结果

期刊:BMC Cancer
影响因子:3.4
doi:10.1186/s12885-025-14992-2
Nishikawa, Kazuo; Otsuka, Taiga; Shimokawa, Mototsugu; Inagaki, Takashi; Komori, Azusa; Todaka, Akiko; Otsu, Satoshi; Shibuki, Taro; Nakazawa, Junichi; Arima, Shiho; Miwa, Keisuke; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Shimokawa, Hozumi; Takeshita, Shigeyuki; Hosokawa, Ayumu; Sakai, Tatsunori; Oda, Hisanobu; Kawahira, Machiko; Arita, Shuji; Honda, Takuya; Taguchi, Hiroki; Tsuneyoshi, Kengo; Fujita, Toshihiro; Sakae, Takahiro; Kawaguchi, Yasunori; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
胰腺癌
肿瘤
肿瘤免疫
发表日期：2025
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Efficacy of third-line chemotherapy following nanoliposomal irinotecan combined with fluorouracil and folinic acid as second-line treatment for unresectable pancreatic cancer

纳米脂质体伊立替康联合氟尿嘧啶和亚叶酸钙作为二线治疗方案后，三线化疗对不可切除胰腺癌的疗效

期刊:Frontiers in Oncology
影响因子:3.3
doi:10.3389/fonc.2025.1626689
Miwa, Keisuke; Kawasaki, Reina; Shimokawa, Mototsugu; Otsuka, Taiga; Tanaka, Toshimitsu; Fukahori, Masaru; Shibuki, Taro; Nakazawa, Junichi; Arima, Shiho; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Shimokawa, Hozumi; Takeshita, Shigeyuki; Nishikawa, Kazuo; Komori, Azusa; Otsu, Satoshi; Hosokawa, Ayumu; Sakai, Tatsunori; Oda, Hisanobu; Kawahira, Machiko; Arita, Shuji; Honda, Takuya; Taguchi, Hiroki; Tsuneyoshi, Kengo; Fujita, Toshihiro; Sakae, Takahiro; Kawaguchi, Yasunori; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
胰腺癌
肿瘤
肿瘤免疫
发表日期：2025
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Nanoliposomal irinotecan with fluorouracil and folinic acid, FOLFIRINOX, and S-1 as second-line treatment for unresectable pancreatic cancer after gemcitabine/nab-paclitaxel

纳米脂质体伊立替康联合氟尿嘧啶和亚叶酸钙（FOLFIRINOX方案）和S-1作为吉西他滨/白蛋白紫杉醇治疗后不可切除胰腺癌的二线治疗方案

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-65689-8
Shibuki, Taro; Otsuka, Taiga; Shimokawa, Mototsugu; Nakazawa, Junichi; Arima, Shiho; Fukahori, Masaru; Miwa, Keisuke; Okabe, Yoshinobu; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Makiyama, Akitaka; Shimokawa, Hozumi; Takeshita, Shigeyuki; Nishikawa, Kazuo; Komori, Azusa; Otsu, Satoshi; Hosokawa, Ayumu; Sakai, Tatsunori; Oda, Hisanobu; Kawahira, Machiko; Arita, Shuji; Honda, Takuya; Taguchi, Hiroki; Tsuneyoshi, Kengo; Kawaguchi, Yasunori; Fujita, Toshihiro; Sakae, Takahiro; Nio, Kenta; Ide, Yasushi; Ureshino, Norio; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
胰腺癌
肿瘤
肿瘤免疫
发表日期：2024
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A multicenter retrospective observational NAPOLEON2 study of nanoliposomal irinotecan with fluorouracil and folinic acid in patients with unresectable pancreatic cancer

一项多中心回顾性观察性 NAPOLEON2 研究，旨在评估纳米脂质体伊立替康联合氟尿嘧啶和亚叶酸治疗不可切除胰腺癌患者的疗效。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-024-63172-y
Kodama, Tomoko; Imajima, Takashi; Shimokawa, Mototsugu; Otsuka, Taiga; Kawahira, Masahiro; Nakazawa, Junichi; Hori, Takeshi; Shibuki, Taro; Arima, Shiho; Ido, Akio; Miwa, Keisuke; Okabe, Yoshinobu; Koga, Futa; Ueda, Yujiro; Kubotsu, Yoshihito; Shimokawa, Hozumi; Takeshita, Shigeyuki; Nishikawa, Kazuo; Komori, Azusa; Otsu, Satoshi; Hosokawa, Ayumu; Sakai, Tatsunori; Sakai, Kenji; Oda, Hisanobu; Kawahira, Machiko; Arita, Shuji; Honda, Takuya; Taguchi, Hiroki; Tsuneyoshi, Kengo; Kawaguchi, Yasunori; Fujita, Toshihiro; Sakae, Takahiro; Shirakawa, Tsuyoshi; Mizuta, Toshihiko; Mitsugi, Kenji
胰腺癌
肿瘤
肿瘤免疫
发表日期：2024
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