日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors

整合多组学和药物敏感性分析揭示儿童实体瘤的潜在生物标志物和治疗策略

ElHarouni, Dina; Hernansaiz-Ballesteros, Rosa; Peterziel, Heike; Balasubramanian, Gnana Prakash; Previti, Christopher; Schramm, Kathrin; Blattner-Johnson, Mirjam; Kabbe, Rolf; Jones, Barbara C; Oppermann, Sina; Jones, David T W; Pfister, Stefan M; Witt, Olaf; Saez-Rodriguez, Julio; Oehme, Ina; Jäger, Natalie; Schlesner, Matthias

New cell lines expanding the diversity of Ewing sarcoma models

新的细胞系扩展了尤文氏肉瘤模型的多样性

Kerkhoff, Maximilian; Schaefer, Christiane; Dirks, Wilhelm G; Krzeciesa, Dawid; Bretschneider, Maximilian; Plaumann, Pauline R; Guder, Wiebke K; Streitbürger, Arne; Herter, Sonja; Peterziel, Heike; Oehme, Ina; Zahnow, Felina; Grünewald, Thomas G P; Dirksen, Uta

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.

临床前药物筛选发现 WEE1 抑制剂和长春花生物碱可作为李-弗劳梅尼综合征髓母细胞瘤的联合治疗方案。

Kolodziejczak Anna S, Selt Florian, Peterziel Heike, Jamaladdin Nora, Mack Norman, Maaß Kendra, Meulenbroeks Chris, Sigaud Romain, Herold-Mende Christel, El Damaty Ahmed, Burhenne Jürgen, Ohmura Shunya, Holland-Letz Tim, Kutscher Lena M, Ernst Aurélie, Wei Pei-Chi, Grünewald Thomas G P, Oehme Ina, Kool Marcel, Jones David T W, Pajtler Kristian W, Kratz Christian P, Pfister Stefan M, Witt Olaf, Milde Till

Ependymoma group-specific blood-brain barrier differences uncovered by a multi-omics approach.

通过多组学方法揭示室管膜瘤组特异性血脑屏障差异。

Sundheimer Julia K, Benzel Julia, Federico Aniello, Volz Stefanie, Knoll Maximilian, Statz Britta, Zheng Tuyu, Kmiecik Szymon W, Burhenne Jürgen, Bajraktari-Sylejmani Gzona, Scheuermann Sophia, King Anke, Müller Torsten, Hübner Jens-Martin, Kalxdorf Mathias, Peterziel Heike, Oehme Ina, Krijgsveld Jeroen, Seitz Christian M, Kool Marcel, Pfister Stefan M, Pajtler Kristian W, Maaß Kendra K

Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells

鉴定出一种靶向激活的检查点激酶-1的蛋白水解嵌合体,揭示了其在肿瘤细胞中的非催化功能

Ashry, Ramy; Abdelsalam, Mohamed; Hausen, Julia; Hieber, Christoph; Zeyn, Yanira; Sarnow, Anne-Christin; Schmidt, Matthias; Najafi, Sara; Oehme, Ina; Bros, Matthias; Chen, Jia-Xuan; Dejung, Mario; Sippl, Wolfgang; Krämer, Oliver H

Genomic and phenotypic stability of fusion-driven pediatric sarcoma cell lines

融合驱动的儿童肉瘤细胞系的基因组和表型稳定性

Kasan, Merve; Geyer, Florian H; Siebenlist, Jana; Sill, Martin; Öllinger, Rupert; Faehling, Tobias; de Álava, Enrique; Surdez, Didier; Dirksen, Uta; Oehme, Ina; Scotlandi, Katia; Delattre, Olivier; Müller-Nurasyid, Martina; Rad, Roland; Strauch, Konstantin; Grünewald, Thomas G P; Cidre-Aranaz, Florencia

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas.

体细胞基因导入能够忠实地重现高危肉瘤的分子谱

Imle Roland, Blösel Daniel, Kommoss Felix K F, Placke Sara, Stutheit-Zhao Eric, Blume Christina, Lupar Dmitry, Schmitt Lukas, Winter Claudia, Wagner Lena, von Eicke Malte, Walzer Hannah, Förderer Julia, Laier Stephanie, Hertwig Michael, Peterziel Heike, Oehme Ina, Scheuerman Sophia, Seitz Christian M, Geyer Florian H, Cidre-Aranaz Florencia, Grünewald Thomas G P, Vokuhl Christian, Chudasama Priya, Scholl Claudia, Schmidt Claudia, Günther Patrick, Sill Martin, Jones Kevin B, Pfister Stefan M, Autry Robert J, Banito Ana

High 4E-BP1 expression associates with chromosome 8 gain and CDK4/6 sensitivity in Ewing sarcoma

尤文氏肉瘤中高表达的 4E-BP1 与 8 号染色体扩增和 CDK4/6 敏感性相关

Funk, Cornelius M; Ehlers, Anna C; Orth, Martin F; Aljakouch, Karim; Li, Jing; Hölting, Tilman Lb; Will, Rainer; Geyer, Florian H; Ceranski, A Katharina; Willis, Franziska; Vinca, Endrit; Ohmura, Shunya; Imle, Roland; Siebenlist, Jana; Yershova, Angelina; Knott, Maximilian Ml; Zahnow, Felina; Sastre, Ana; Alonso, Javier; Sahm, Felix; Peterziel, Heike; Loboda, Anna; Schneider, Martin; Banito, Ana; Leprivier, Gabriel; Hartmann, Wolfgang; Dirksen, Uta; Witt, Olaf; Oehme, Ina; Pfister, Stefan M; Romero-Pérez, Laura; Krijgsveld, Jeroen; Cidre-Aranaz, Florencia; Grünewald, Thomas Gp; Musa, Julian

The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells

蛋白质去乙酰化酶HDAC10控制恶性淋巴细胞中的DNA复制。

Mieland, Andreas O; Petrosino, Giuseppe; Dejung, Mario; Chen, Jia-Xuan; Fulzele, Amitkumar; Mahmoudi, Fereshteh; Tu, Jia-Wey; Mustafa, Al-Hassan M; Zeyn, Yanira; Hieber, Christoph; Bros, Matthias; Schnöder, Tina M; Heidel, Florian H; Najafi, Sara; Oehme, Ina; Hofmann, Ilse; Schutkowski, Mike; Hilscher, Sebastian; Kosan, Christian; Butter, Falk; Bhatia, Sanil; Sippl, Wolfgang; Krämer, Oliver H

High content-imaging drug synergy screening identifies specific senescence-related vulnerabilities of mesenchymal neuroblastomas.

高内涵成像药物协同筛选可识别间充质神经母细胞瘤的特定衰老相关脆弱性

Herter Sonja, Emperador Marta, Smyrilli Kyriaki, Kocher Daniela, Celikyürekli Simay, Zeiser Constantia, Gerloff Xenia, Kreth Sina, Henrich Kai-Oliver, Maaß Kendra K, Rettenmeier Johanna, Grünewald Thomas G P, Peterziel Heike, Westermann Frank, Hamacher-Brady Anne, Witt Olaf, Oehme Ina