Upregulating β-hexosaminidase activity in rodents prevents α-synuclein lipid associations and protects dopaminergic neurons from α-synuclein-mediated neurotoxicity
在啮齿动物中上调β-己糖胺酶活性可阻止α-突触核蛋白与脂质的结合,并保护多巴胺能神经元免受α-突触核蛋白介导的神经毒性损害。
期刊:Acta Neuropathologica Communications
影响因子:6.2
doi:10.1186/s40478-020-01004-6
Oeystein R Brekk ,Joanna A Korecka ,Cecile C Crapart ,Mylene Huebecker ,Zachary K MacBain ,Sara Ann Rosenthal ,Miguel Sena-Esteves ,David A Priestman ,Frances M Platt ,Ole Isacson ,Penelope J Hallett