日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types.

CDS1 和 CDS2 之间的合成致死相互作用是葡萄膜黑色素瘤以及多种肿瘤类型的弱点

Chan Pui Ying, Alexander Diana, Mehta Ishan, Matsuyama Larissa Satiko Alcantara Sekimoto, Harle Victoria, Olvera-León Rebeca, Park Jun Sung, Arriaga-González Fernanda G, van der Weyden Louise, Cheema Saamin, Iyer Vivek, Offord Victoria, Barneda David, Hawkins Phillip T, Stephens Len, Kozik Zuza, Woods Michael, Wong Kim, Balmus Gabriel, Vinceti Alessandro, Thompson Nicola A, Del Castillo Velasco-Herrera Martin, Wessels Lodewyk, van de Haar Joris, Gonçalves Emanuel, Sinha Sanju, Vázquez-Cruz Martha Estefania, Bisceglia Luisa, Raimondi Francesco, Choudhary Jyoti, Patiyal Sumeet, Venkatesh Anjan, Iorio Francesco, Ryan Colm J, Adams David J

Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma.

FBXW11 和 CTNNB1 热点突变相互排斥,激活 Wnt/β-catenin,从而驱动唾液腺基底细胞腺瘤的发生

Wong Kim, Bishop Justin A, Weinreb Ilan, Motta Marialetizia, Del Castillo Velasco-Herrera Martin, Bellacchio Emanuele, Ferreira Ingrid, van der Weyden Louise, Boccacino Jacqueline M, Lauri Antonella, Rotundo Giovannina, Ciolfi Andrea, Cheema Saamin, Olvera-León Rebeca, Offord Victoria, Droop Alastair, Vermes Ian, Allgäuer Michael, Hyrcza Martin, Anderson Elizabeth, Smith Katie, de Saint Aubain Nicolas, Mogler Carolin, Stenzinger Albrecht, Arends Mark J, Brenn Thomas, Tartaglia Marco, Adams David J

Comprehensive mutational profiling identifies new driver events in cutaneous leiomyosarcoma

全面的突变谱分析揭示了皮肤平滑肌肉瘤中的新驱动事件

van der Weyden, Louise; Del Castillo Velasco-Herrera, Martin; Cheema, Saamin; Wong, Kim; Boccacino, Jacqueline M; Offord, Victoria; Droop, Alastair; Jones, David R A; Vermes, Ian; Anderson, Elizabeth; Hardy, Claire; de Saint Aubain, Nicolas; Ferguson, Peter M; Clarke, Emily L; Merchant, William; Mogler, Carolin; Frew, Derek; Harms, Paul W; Monteagudo, Carlos; Billings, Steven D; Arends, Mark J; Ferreira, Ingrid; Brenn, Thomas; Adams, David J

Exploration of the mutational landscape of cutaneous leiomyoma confirms FH as a driver gene and identifies targeting purine metabolism as a potential therapeutic strategy

对皮肤平滑肌瘤突变图谱的探索证实了FH是驱动基因,并确定靶向嘌呤代谢是一种潜在的治疗策略。

van der Weyden, Louise; Del Castillo Velasco-Herrera, Martin; Cheema, Saamin; Wong, Kim; Boccacino, Jacqueline M; Vermes, Ian; Offord, Victoria; Droop, Alastair; Jones, David R A; Anderson, Elizabeth; Hardy, Claire; de Saint Aubain, Nicolas; Ferguson, Peter M; Mogler, Carolin; Rajan, Neil; Frew, Derek; Harms, Paul W; Billings, Steven D; Schatton, Désirée; Segarra-Mondejar, Marc; Arends, Mark J; Ferreira, Ingrid; Brenn, Thomas; Frezza, Christian; Adams, David J

A compendium of synthetic lethal gene pairs defined by extensive combinatorial pan-cancer CRISPR screening

通过广泛的泛癌CRISPR组合筛选定义的合成致死基因对汇编

Harle, Victoria; Offord, Victoria; Gökbağ, Birkan; Fotopoulos, Lazaros; Williams, Thomas; Alexander, Diana; Mehta, Ishan; Thompson, Nicola A; Olvera-León, Rebeca; Peidli, Stefan; Iyer, Vivek; Gonçalves, Emanuel; Kebabci, Narod; De Kegel, Barbara; van de Haar, Joris; Li, Lang; Ryan, Colm J; Adams, David J

Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response

在一种新出现的动物源性金黄色葡萄球菌398型菌株中,两种含有TIR样结构域的蛋白质可能是潜在的毒力因子,它们通过影响宿主的先天免疫反应发挥作用。

Patterson, Nicholas J; Günther, Juliane; Gibson, Amanda J; Offord, Victoria; Coffey, Tracey J; Splitter, Gary; Monk, Ian; Seyfert, Hans-Martin; Werling, Dirk

Global gene expression profiling of myeloid immune cell subsets in response to in vitro challenge with porcine circovirus 2b

猪圆环病毒2b体外感染后髓系免疫细胞亚群的全局基因表达谱分析

Mavrommatis, Bettina; Offord, Victoria; Patterson, Robert; Watson, Mick; Kanellos, Theo; Steinbach, Falko; Grierson, Sylvia; Werling, Dirk

Potential evidence for biotype-specific chemokine profile following BVDV infection of bovine macrophages

牛病毒性腹泻病毒感染牛巨噬细胞后,生物型特异性趋化因子谱的潜在证据

Burr, Stephen; Thomas, Carole; Brownlie, Joe; Offord, Victoria; Coffey, Tracey J; Werling, Dirk