日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV‑2 Main Protease

单个卤素原子取代对靶向SARS-CoV-2主蛋白酶抑制剂抗病毒活性的影响

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.5c10895
Bulut, Haydar; Higashi-Kuwata, Nobuyo; Ogata-Aoki, Hiromi; Hayashi, Hironori; Takamune, Nobutoki; Kishimoto, Naoki; Das, Debananda; Li, Mi; Wlodawer, Alexander; Misumi, Shogo; Tamamura, Hirokazu; Mitsuya, Hiroaki
微生物学
SARS-CoV-2
发表日期：2026
文献求助 收藏

Macrophages with different origins proliferate ex vivo and do not lose their core intrinsic features

不同来源的巨噬细胞在体外增殖后不会丧失其核心固有特征。

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2025.112635
Sara A Habash ，Naofumi Takahashi ，Youssef M Eltalkhawy ，Randa A Abdelnaser ，Hiromi Ogata-Aoki ，Seiji Okada ，Hitoshi Takizawa ，Shingo Usuki ，Kan Etoh ，Shinjiro Hino ，Saori Morino-Koga ，Minetaro Ogawa ，Shinya Suzu
巨噬细胞
巨噬细胞
免疫/内分泌
细胞生物学
发表日期：2025
文献求助 收藏

An orally available P1'-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier

口服 P1'-5-氟化 Mpro 抑制剂无需加强剂即可阻断 SARS-CoV-2 复制，且具有较高的遗传屏障

期刊:PNAS Nexus
影响因子:2.2
doi:10.1093/pnasnexus/pgae578
Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Maki Kiso, Nobutoki Takamune, Naoki Kishimoto, Shin-Ichiro Hattori, Takahiro Ishii, Takuya Kobayakawa, Kenta Nakano, Yukiko Shimizu, Debananda Das, Junji Saruwatari, Kazuya Hasegawa, Kazutaka Murayama, Yoshikazu S
免疫
新冠
Most
Goat
IgG F(ab')2
发表日期：2025
文献求助 收藏

Establishment of Biobank and Patient-Derived Xenograft of Soft Tissue and Bone Tumors

建立软组织和骨肿瘤生物样本库及患者来源异种移植模型

期刊:Cureus Journal of Medical Science
影响因子:1.3
doi:10.7759/cureus.74781
Okada, Seiji; Boonnate, Piyanard; Panaampon, Jutatip; Saisuwan, Krittamate; Ogata-Aoki, Hiromi; Abe, Makoto; Hirabayashi, Kaoru; Nakagawa, Rumi; Kikuta, Kazutaka
肿瘤
肿瘤免疫
发表日期：2024
文献求助 收藏

Identification of SARS-CoV-2 Mpro inhibitors containing P1' 4-fluorobenzothiazole moiety highly active against SARS-CoV-2

鉴定含有P1' 4-氟苯并噻唑基团的SARS-CoV-2 Mpro抑制剂，该抑制剂对SARS-CoV-2具有高度活性

期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-023-36729-0
Nobuyo Higashi-Kuwata,Kohei Tsuji,Hironori Hayashi,Haydar Bulut,Maki Kiso,Masaki Imai,Hiromi Ogata-Aoki,Takahiro Ishii,Takuya Kobayakawa,Kenta Nakano,Nobutoki Takamune,Naoki Kishimoto,Shin-Ichiro Hattori,Debananda Das,Yukari Uemura,Yosuke Shimizu,Manabu Aoki,Kazuya Hasegawa,Satoshi Suzuki,Akie Nishiyama,Junji Saruwatari,Yukiko Shimizu,Yoshikazu Sukenaga,Yuki Takamatsu,Kiyoto Tsuchiya,Kenji Maeda,Kazuhisa Yoshimura,Shun Iida,Seiya Ozono,Tadaki Suzuki,Tadashi Okamura,Shogo Misumi,Yoshihiro Kawaoka,Hirokazu Tamamura,Hiroaki Mitsuya
新冠
SARS-CoV-2
发表日期：2023
文献求助 收藏

Identification of a novel long-acting 4'-modified nucleoside reverse transcriptase inhibitor against HBV

鉴定出一种新型长效4'-修饰核苷类逆转录酶抑制剂，用于对抗乙型肝炎病毒

期刊:Journal of Hepatology
影响因子:33
doi:10.1016/j.jhep.2020.12.006
Higashi-Kuwata, Nobuyo; Hayashi, Sanae; Kumamoto, Hiroki; Ogata-Aoki, Hiromi; Das, Debananda; Venzon, David; Hattori, Shin-Ichiro; Bulut, Haydar; Hashimoto, Mai; Otagiri, Masaki; Takamune, Nobutoki; Kishimoto, Naoki; Davis, David A; Misumi, Shogo; Kakuni, Masakazu; Tanaka, Yasuhito; Mitsuya, Hiroaki
微生物学
肝炎
发表日期：2021
文献求助 收藏

Raltegravir blocks the infectivity of red-fluorescent-protein (mCherry)-labeled HIV-1(JR-FL) in the setting of post-exposure prophylaxis in NOD/SCID/Jak3(-/-) mice transplanted with human PBMCs

在接受人外周血单核细胞移植的NOD/SCID/Jak3(-/-)小鼠中，拉替拉韦可阻断暴露后预防中红色荧光蛋白（mCherry）标记的HIV-1(JR-FL)的感染性。

期刊:Antiviral Research
影响因子:4
doi:10.1016/j.antiviral.2017.09.003
Ogata-Aoki, Hiromi; Higashi-Kuwata, Nobuyo; Hattori, Shin-Ichiro; Hayashi, Hironori; Danish, Matthew; Aoki, Manabu; Shiotsu, Chiemi; Hashiguchi, Yumi; Hamada, Akinobu; Kobayashi, Hisataka; Ihn, Hironobu; Okada, Seiji; Mitsuya, Hiroaki
IF
HIV
炎症/感染
微生物学
单核细胞
细胞生物学
发表日期：2018
文献求助 收藏

Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3(-/-) mice

在移植了人外周血单核细胞的NOD/SCID/Jak3(-/-)小鼠中，可追踪的携带mCherry荧光蛋白的HIV-1感染的早期动力学

期刊:Antiviral Research
影响因子:4
doi:10.1016/j.antiviral.2017.03.027
Higashi-Kuwata, Nobuyo; Ogata-Aoki, Hiromi; Hattori, Shin-Ichiro; Hayashi, Hironori; Danish, Matthew; Aoki, Manabu; Shiotsu, Chiemi; Kawamura, Tatsuyoshi; Ihn, Hironobu; Kobayashi, Hisataka; Okada, Seiji; Mitsuya, Hiroaki
IF
HIV
炎症/感染
微生物学
单核细胞
细胞生物学
发表日期：2017
文献求助 收藏

Effects of CC chemokine receptor 5 (CCR5) inhibitors on the dynamics of CCR5 and CC-chemokine-CCR5 interactions

CC 趋化因子受体 5 (CCR5) 抑制剂对 CCR5 和 CC-趋化因子-CCR5 相互作用动力学的影响

期刊:Antiviral Therapy
影响因子:1.3
doi:10.3851/IMP1529
Hirotomo Nakata, Michael Kruhlak, Wakako Kamata, Hiromi Ogata-Aoki, Jianfeng Li, Kenji Maeda, Arun K Ghosh, Hiroaki Mitsuya
信号转导
发表日期：2010
文献求助 收藏

Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition

CCR5 的第二个胞外环和跨膜残基参与抑制剂结合和 HIV-1 融合：对变构抑制机制的见解

期刊:Journal of Molecular Biology
影响因子:4.7
doi:10.1016/j.jmb.2008.06.041
Kenji Maeda, Debananda Das, Philip D Yin, Kiyoto Tsuchiya, Hiromi Ogata-Aoki, Hirotomo Nakata, Rachael B Norman, Lauren A Hackney, Yoshikazu Takaoka, Hiroaki Mitsuya
免疫
艾滋病
发表日期：2008
文献求助 收藏