日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The extracellular heparan sulfatase SULF2 limits myeloid IFNβ signaling and Th17 responses in inflammatory arthritis

细胞外硫酸乙酰肝素酶SULF2限制炎症性关节炎中的髓系IFNβ信号传导和Th17反应

Swart, Maarten; Redpath, Andia N; Ogbechi, Joy; Cardenas, Ryan; Topping, Louise; Compeer, Ewoud B; Goddard, Michael; Chanalaris, Anastasios; Williams, Richard; Brewer, Daniel S; Smart, Nicola; Monaco, Claudia; Troeberg, Linda

Induction of IDO1 and Kynurenine by Serine Proteases Subtilisin, Prostate Specific Antigen, CD26 and HtrA: A New Form of Immunosuppression?

丝氨酸蛋白酶枯草杆菌蛋白酶、前列腺特异性抗原、CD26 和 HtrA 诱导 IDO1 和犬尿氨酸:一种新的免疫抑制形式?

Felix I L Clanchy, Yi-Shu Huang, Joy Ogbechi, L Gail Darlington, Richard O Williams, Trevor W Stone

Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)

群体感应分子 2-庚基-3-羟基-4-喹诺酮 (PQS) 对免疫细胞功能、IDO 表达和犬尿氨酸生成的调节

Joy Ogbechi ,Yi-Shu Huang ,Felix I L Clanchy ,Eirini Pantazi ,Louise M Topping ,L Gail Darlington ,Richard O Williams ,Trevor W Stone

Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions

异常的基质组织因子定位和肌内酯驱动的血管功能障碍(因 IL-1β 而加剧)与布鲁里溃疡病变中的纤维蛋白形成有关

Louise Tzung-Harn Hsieh, Scott J Dos Santos, Belinda S Hall, Joy Ogbechi, Aloysius D Loglo, Francisco Javier Salguero, Marie-Thérèse Ruf, Gerd Pluschke, Rachel E Simmonds

Mycolactone enhances the Ca2+ leak from endoplasmic reticulum by trapping Sec61 translocons in a Ca2+ permeable state

霉菌内酯通过将 Sec61 转位子捕获在 Ca2+ 可渗透状态下,增强内质网中 Ca2+ 的泄漏。

Bhadra, Pratiti; Dos Santos, Scott; Gamayun, Igor; Pick, Tillman; Neumann, Clarissa; Ogbechi, Joy; Hall, Belinda S; Zimmermann, Richard; Helms, Volkhard; Simmonds, Rachel E; Cavalié, Adolfo

Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis

药物调节 T 细胞免疫可导致自身免疫性关节炎的长期缓解

Yi-Shu Huang, Wen-Yi Tseng, Felix I L Clanchy, Louise M Topping, Joy Ogbechi, Kay McNamee, Dany Perocheau, Nien-Yi Chiang, Peter Ericsson, Anette Sundstedt, Zhong-Tian Xue, Leif G Salford, Hans-Olov Sjögren, Trevor W Stone, Hsi-Hsien Lin, Shue-Fen Luo, Richard O Williams

cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing Tregs

cIAP1/2 抑制与 TNF 抑制在自身免疫中产生协同作用,通过下调 IL-17A 和诱导 Treg

Joanna Z Kawalkowska, Joy Ogbechi, Patrick J Venables, Richard O Williams

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4

霉菌内酯抑制Sec61依赖性转位,使整合应激反应与内质网应激解耦,并通过ATF4的翻译激活驱动细胞毒性。

Ogbechi, Joy; Hall, Belinda S; Sbarrato, Thomas; Taunton, Jack; Willis, Anne E; Wek, Ronald C; Simmonds, Rachel E

Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

霉菌内酯依赖性内皮细胞血栓调节蛋白耗竭与布鲁里溃疡病变中的纤维蛋白沉积密切相关

Ogbechi, Joy; Ruf, Marie-Thérèse; Hall, Belinda S; Bodman-Smith, Katherine; Vogel, Moritz; Wu, Hua-Lin; Stainer, Alexander; Esmon, Charles T; Ahnström, Josefin; Pluschke, Gerd; Simmonds, Rachel E

The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER

溃疡分枝杆菌毒力因子 mycolactone 的致病机制依赖于阻断蛋白质转位进入内质网

Belinda S Hall, Kirsti Hill, Michael McKenna, Joy Ogbechi, Stephen High, Anne E Willis, Rachel E Simmonds