日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PI3Kγ inhibition drives M1 macrophage differentiation and synergizes with PD-L1 blockade to improve survival in poorly immunogenic head and neck squamous cell carcinoma

PI3Kγ抑制剂可促进M1型巨噬细胞分化,并与PD-L1阻断剂协同作用,提高免疫原性较差的头颈部鳞状细胞癌患者的生存率。

Jordanides, Pete P; Jagadeesha, Sushmitha; Upadhaya, Puja; Ryan, Nathan M; Anderson, Kelvin; Lamenza, Felipe F; Shrestha, Suvekshya; Siddiqui, Arham; Bopp, Anna R; Pracha, Sherefuddin H; Roth, Peyton; Kehres, Reegan; Mo, Xiaokui; Oghumu, Steve

Sex-based immune differences influence tumor progression in head and neck squamous cell carcinoma.

性别相关的免疫差异会影响头颈部鳞状细胞癌的肿瘤进展。

Jagadeesha Sushmitha, Lamenza Felipe, Upadhaya Puja, Chung Catherine, Webb Amy, Nyati Kishan, Ramalingam Ravi, Shrestha Suvekshya, Masood Shaheer, Dasari Sonali, Kazmierowicz Natalie, Oghumu Steve

Efficacy of anti-LAG3 and anti-PD-1 combination checkpoint inhibitor therapy against head and neck squamous cell carcinoma in a genetically engineered mouse model.

在基因工程小鼠模型中,抗 LAG3 和抗 PD-1 联合检查点抑制剂疗法对头颈部鳞状细胞癌的疗效。

Lamenza Felipe F, Roth Peyton, Upadhaya Puja, Shrestha Suvekshya, Jagadeesha Sushmitha, Kazmierowicz Natalie, Horn Natalie, Pracha Hasan, Dasari Sonali, Oghumu Steve

Analysis of head and neck cancer scRNA-seq data identified PRDM6 promotes tumor progression by modulating immune gene expression.

对头颈癌单细胞RNA测序数据的分析发现,PRDM6通过调节免疫基因表达促进肿瘤进展。

Wu Zhenyu, Lepcha Thurbu Tshering, Zhou Dawei, He Zhixian, Fiches Guillaume N, Park Youngmin, He Jinshan, Chen Jianwen, Shanaka K A S N, Oghumu Steve, Zhao Weiqiang, Ma Anjun, Ma Qin, Zhu Jian, Santoso Netty G

Inhibition of head and neck squamous cell carcinoma by Bruton's tyrosine kinase inhibitor ibrutinib is associated with reduction of immunosuppressive T cells.

布鲁顿酪氨酸激酶抑制剂伊布替尼对头颈部鳞状细胞癌的抑制作用与免疫抑制性 T 细胞的减少有关

Bopp Anna R, Lamenza Felipe F, Upadhaya Puja, Ryan Nathan M, Kazmierowicz Natalie, Jordanides Pete P, Siddiqui Arham, Pracha Sherefuddin H, Roth Peyton, Iwenofu O Hans, Oghumu Steve

Targeting macrophage migration inhibitory factor to inhibit T cell immunosuppression in the tumor microenvironment and improve cancer outcomes in head and neck squamous cell carcinoma.

靶向巨噬细胞迁移抑制因子,抑制肿瘤微环境中的T细胞免疫抑制,改善头颈部鳞状细胞癌的治疗效果

Pracha S Hasan, Shrestha Suvekshya, Ryan Nathan, Upadhaya Puja, Lamenza Felipe F, Jagadeesha Sushmitha, Jordanides Pete, Roth Peyton, Springer Anna, Oghumu Steve

Durable Response to Pazopanib (Tyrosine Kinase Inhibitor) in a Patient With EWSR1::CREM Gene Fusion Positive Intra-Abdominal Unclassified Epithelioid Sarcoma

帕唑帕尼(酪氨酸激酶抑制剂)治疗EWSR1::CREM基因融合阳性腹腔内未分类上皮样肉瘤患者,疗效持久

Shafi, Saba; Jones, Dan; Pan, Xiaokang; Husain, Marium; Rogers, Alan; Oghumu, Steve; Iwenofu, O Hans

Analysis of Head and Neck Cancer scRNA-seq Data Identified PRDM6 Promotes Tumor Progression by Modulating Immune Gene Expression.

对头颈癌单细胞RNA测序数据的分析表明,PRDM6通过调节免疫基因表达促进肿瘤进展

Wu Zhenyu, Lepcha Thurbu Tshering, Zhou Dawei, He Zhixian, Fiches Guillaume N, Park Youngmin, He Jinshan, Chen Jianwen, Shanaka K A S N, Oghumu Steve, Zhao Weiqiang, Ma Anjun, Ma Qin, Zhu Jian, Santoso Netty G

Berries vs. Disease: Revenge of the Phytochemicals

浆果对抗疾病:植物化学物质的复仇

Lamenza, Felipe F; Upadhaya, Puja; Roth, Peyton; Shrestha, Suvekshya; Jagadeesha, Sushmitha; Horn, Natalie; Pracha, Hasan; Oghumu, Steve

Host derived macrophage migration inhibitory factor expression attenuates anti-tumoral immune cell accumulation and promotes immunosuppression in the tumor microenvironment of head and neck squamous cell carcinoma.

宿主来源的巨噬细胞迁移抑制因子表达减弱了抗肿瘤免疫细胞的积累,并促进了头颈部鳞状细胞癌肿瘤微环境中的免疫抑制

Ryan Nathan, Lamenza Felipe, Shrestha Suvekshya, Upadhaya Puja, Springer Anna, Jordanides Pete, Pracha Hasan, Roth Peyton, Kumar Rathan, Wang Yinchong, Vilgelm Anna E, Satoskar Abhay, Oghumu Steve