日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule.

通过精确确定表位并利用 CD30 分子的结构特征，从激动性抗体生成拮抗性双位点抗 CD30 抗体

期刊:Antibody Therapeutics
影响因子:4.5
doi:10.1093/abt/tbaf002
Akiba Hiroki, Ise Tomoko, Satoh Reiko, Abe Yasuhiro, Tsumoto Kouhei, Ohno Hiroaki, Kamada Haruhiko, Nagata Satoshi
免疫/内分泌
CD3
发表日期：2025
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Oligolysine Enhances and Inhibits DNA Condensate Formation

寡聚赖氨酸既能增强也能抑制DNA凝聚体的形成

期刊:ACS Omega
影响因子:4.3
doi:10.1021/acsomega.5c01928
Ohno, Hiroaki; Kijima, Junko; Ochi, Yosuke; Shoji, Masaaki; Taira, Junichi; Mabuchi, Takuya; Sato, Yusuke
发表日期：2025
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Conversion of an agonistic anti-TNFR2 biparatopic antibody into an antagonist by insertion of peptide linkers into the hinge region

通过在铰链区插入肽连接子，将激动型抗TNFR2双位点抗体转化为拮抗剂

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2025.110548
Otsuki, Takuya; Matsumoto, Shigeyuki; Fujita, Junso; Miyata, Tomoko; Namba, Keiichi; Kanada, Ryo; Okuno, Yasushi; Kamada, Haruhiko; Ohno, Hiroaki; Akiba, Hiroki
发表日期：2025
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Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury

Eed 依赖性组蛋白修饰调控 iNKT 细胞发育程序，减轻肝损伤

期刊:Frontiers in Immunology
影响因子:5.7
doi:10.3389/fimmu.2024.1467774
Yun Guo, Shun Ohki, Yohei Kawano, Weng Sheng Kong, Yoshinori Ohno, Hiroaki Honda, Masamoto Kanno, Tomoharu Yasuda
代谢
肝损伤
T细胞
发表日期：2024
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Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A

合成替代物的设计，用于替代Coibamide A中的大环内酯连接基团

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.3c00232
Suzuki, Rikito; Mattos, Daphne R; Kitamura, Takashi; Tsujioka, Rina; Kobayashi, Kazuya; Inuki, Shinsuke; Ohno, Hiroaki; Ishmael, Jane E; McPhail, Kerry L; Oishi, Shinya
发表日期：2023
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Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I)

双磺酰胺类化合物作为线粒体 NADH-醌氧化还原酶（复合物 I）新型抑制剂的发现

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.2c00504
Tsuji, Atsuhito; Masuya, Takahiro; Arichi, Norihito; Inuki, Shinsuke; Murai, Masatoshi; Miyoshi, Hideto; Ohno, Hiroaki
线粒体
发表日期：2023
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Design and Synthesis of Monobody Variants with Low Immunogenicity

低免疫原性单克隆抗体变体的设计与合成

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.3c00342
Iwamoto, Naoya; Sato, Yukino; Manabe, Asako; Inuki, Shinsuke; Ohno, Hiroaki; Nonaka, Motohiro; Oishi, Shinya
单克隆抗体
免疫/内分泌
发表日期：2023
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Direct synthesis of aryl-annulated [c]carbazoles by gold(i)-catalysed cascade reaction of azide-diynes and arenes

金(I)催化叠氮二炔与芳烃级联反应直接合成芳基稠合[c]咔唑

期刊:Chemical Science
影响因子:7.4
doi:10.1039/c8sc03525c
Kawada, Yuiki; Ohmura, Shunsuke; Kobayashi, Misaki; Nojo, Wataru; Kondo, Masaki; Matsuda, Yuka; Matsuoka, Junpei; Inuki, Shinsuke; Oishi, Shinya; Wang, Chao; Saito, Tatsuo; Uchiyama, Masanobu; Suzuki, Takanori; Ohno, Hiroaki
信号转导
发表日期：2018
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Structure-Activity Relationship Study on Odoamide: Insights into the Bioactivities of Aurilide-Family Hybrid Peptide-Polyketides

对奥多酰胺的构效关系研究：深入了解奥利利德家族杂合肽-聚酮化合物的生物活性

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.8b00028
Kaneda, Masato; Kawaguchi, Shinsaku; Fujii, Nobutaka; Ohno, Hiroaki; Oishi, Shinya
发表日期：2018
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Synthesis and biological evaluation of the [d-MeAla(11)]-epimer of coibamide A

合成并评价了coibamide A的[d-MeAla(11)]-差向异构体

期刊:Bioorganic & Medicinal Chemistry Letters
影响因子:2.2
doi:10.1016/j.bmcl.2014.11.044
Nabika, Ryota; Suyama, Takashi L; Hau, Andrew M; Misu, Ryosuke; Ohno, Hiroaki; Ishmael, Jane E; McPhail, Kerry L; Oishi, Shinya; Fujii, Nobutaka
发表日期：2015
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