Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody
抑制硬脂酰辅酶A去饱和酶1 (SCD1) 可通过调节癌细胞中的β-catenin信号通路和T细胞中的内质网应激来增强抗肿瘤T细胞反应,并与抗PD-1抗体产生协同作用。
期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2022-004616
Katoh, Yuki; Yaguchi, Tomonori; Kubo, Akiko; Iwata, Takashi; Morii, Kenji; Kato, Daiki; Ohta, Shigeki; Satomi, Ryosuke; Yamamoto, Yasuhiro; Oyamada, Yoshitaka; Ouchi, Kota; Takahashi, Shin; Ishioka, Chikashi; Matoba, Ryo; Suematsu, Makoto; Kawakami, Yutaka
SCD
肿瘤
T细胞
肿瘤免疫
信号转导
内质网应激
T细胞
细胞生物学
PD-1
免疫/内分泌