日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Epigenetic Dysregulation of the NKX2-1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

NKX2-1/SPDEF轴的表观遗传失调驱动慢性阻塞性肺疾病中持续的杯状细胞分化和上皮屏障功能障碍

期刊:Respirology
影响因子:6.3
doi:10.1002/resp.70201
Shiota, Ayaka; Kan-O, Keiko; Ishii, Yumiko; Koga, Tomoaki; Sawada, Takeshi; Yasunaga, Kei-Ichiro; Usuki, Shingo; Katsuno, Tatsuya; Inoue, Shigesato; Ogawa, Tomohiro; Jo, Akihiro; Fukuyama, Satoru; Nakao, Mitsuyoshi; Ogata, Hiroaki; Kido, Mizuho A; Tsukita, Sachiko; Matsumoto, Koichiro; Okamoto, Isamu
SPDEF
细胞生物学
表观遗传
慢性阻塞性肺疾病
发表日期：2026
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Association Between Single Nucleotide Polymorphisms and Disease Susceptibility, Survival, and Acute Exacerbation in Idiopathic Pulmonary Fibrosis

单核苷酸多态性与特发性肺纤维化疾病易感性、生存率和急性加重之间的关联

期刊:Respirology
影响因子:6.3
doi:10.1111/resp.70120
Tsubouchi, Kazuya; Yanagihara, Toyoshi; Kiyomi, Fumiaki; Yamamoto, Yuzo; Arimura-Omori, Masako; Hamada, Naoki; Ichiki, Katsuyuki; Takata, Shohei; Ishii, Hiroshi; Kitasato, Yasuhiko; Okamoto, Masaki; Kawakami, Satoru; Yatera, Kazuhiro; Kawasaki, Masayuki; Fujita, Masaki; Tokunaga, Shoji; Kiyohara, Chikako; Nakanishi, Yoichi; Okamoto, Isamu
特发性肺纤维化
发表日期：2026
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Clinical characteristics, prognostic factors, and feasibility of ICI continuation in immune checkpoint inhibitor-related pneumonitis

免疫检查点抑制剂相关性肺炎的临床特征、预后因素及继续使用免疫检查点抑制剂的可行性

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-026-04375-2
Masumoto, Keisuke; Tsubouchi, Kazuya; Matsukane, Ryosuke; Yasukochi, Sai; Ogata, Hiroaki; Takano, Tomotsugu; Uchida, Mayako; Okamoto, Isamu
肺炎
免疫/内分泌
发表日期：2026
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Impact of vulnerability on concurrent chemoradiotherapy outcomes in patients with locally advanced non-small cell lung cancer using an integrated clinical trial database

利用综合临床试验数据库分析脆弱性对局部晚期非小细胞肺癌患者同步放化疗疗效的影响

期刊:Therapeutic Advances in Medical Oncology
影响因子:4.2
doi:10.1177/17588359251414535
Morimoto, Kenji; Yamada, Tadaaki; Nishioka, Naoya; Yamamoto, Nobuyuki; Niho, Seiji; Okamoto, Isamu; Hotta, Katsuyuki; Okamoto, Hiroaki; Sugawara, Shunichi; Shimokawa, Toshio; Ozawa, Yuichi; Oizumi, Satoshi; Takayama, Koichi
肺癌
细胞生物学
肿瘤
肿瘤免疫
发表日期：2026
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Upfront combination therapy with nintedanib and anti-inflammatory agents for progressive pulmonary fibrosis: a multicentre, single-arm phase 2 study (TOP-ILD)

尼达尼布联合抗炎药一线治疗进行性肺纤维化：一项多中心、单臂 2 期研究 (TOP-ILD)

期刊:Erj Open Research
影响因子:4
doi:10.1183/23120541.00697-2025
Tsubouchi, Kazuya; Hirose, Masayuki; Takei, Reoto; Fujisawa, Tomoyuki; Tobino, Kazunori; Ichiyasu, Hidenori; Izumi, Shinyu; Sakamoto, Noriho; Asami-Noyama, Maki; Nishiyama, Osamu; Waseda, Yuko; Nakanishi, Masanori; Baba, Tomohisa; Chiba, Hirofumi; Furusawa, Haruhiko; Zaizen, Yoshiaki; Ishii, Hiroshi; Okamoto, Masaki; Kondoh, Yasuhiro; Ogura, Takashi; Ichikado, Kazuya; Okamoto, Isamu
发表日期：2026
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The Evaluation of the Diagnostic Yield and Complications Associated with Bronchoscopy via Endobronchial Ultrasound with a Guide Sheath

经支气管内超声引导鞘行支气管镜检查的诊断率及并发症评估

期刊:Internal Medicine
影响因子:1.1
doi:10.2169/internalmedicine.5777-25
Takeda, Keisuke; Ikegame, Satoshi; Iwama, Eiji; Takenaka, Tomoyoshi; Ozono, Keigo; Tsubouchi, Kazuya; Okamoto, Isamu
发表日期：2026
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Serum VEGF-A as a biomarker for the addition of bevacizumab to chemo-immunotherapy in metastatic NSCLC

血清 VEGF-A 作为转移性非小细胞肺癌化疗联合免疫治疗中加用贝伐单抗的生物标志物

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-58186-7
Tanaka, Kentaro; Sugisaka, Jun; Shiraishi, Yoshimasa; Watanabe, Yasutaka; Daga, Haruko; Azuma, Koichi; Nishino, Kazumi; Mori, Masahide; Ota, Takayo; Saito, Haruhiro; Hata, Akito; Sakaguchi, Tadashi; Kozuki, Toshiyuki; Akamatsu, Hiroaki; Matsumoto, Hirotaka; Tachihara, Motoko; Wakuda, Kazushige; Sato, Yuki; Ozaki, Tomohiro; Tsuchiya-Kawano, Yuko; Yamamoto, Nobuyuki; Nakagawa, Kazuhiko; Okamoto, Isamu
肺癌
肿瘤
肿瘤免疫
EGF
VEGF-A
细胞生物学
VEGF
免疫/内分泌
发表日期：2025
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Enhanced HER2 internalization by clathrin-dependent endocytosis in non-small cell lung cancer positive for HER2 mutations.

HER2 突变阳性的非小细胞肺癌中，网格蛋白依赖性内吞作用增强了 HER2 的内化。

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-025-03126-x
Shimauchi Atsushi, Iwama Eiji, Ibusuki Ritsu, Tsutsumi Hirono, Shibahara Daisuke, Otsubo Kohei, Yoneshima Yasuto, Tanaka Kentaro, Okamoto Isamu
肺癌
细胞生物学
HER2
发表日期：2025
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NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors.

NECTIN4 调节非小细胞肺癌细胞中 CD155 的细胞表面表达，并诱导肿瘤对 PD-1 抑制剂产生耐药性

期刊:Cancer Immunology Immunotherapy
影响因子:5.1
doi:10.1007/s00262-025-04079-z
Mizusaki Shun, Yoneshima Yasuto, Iwama Eiji, Nakashima Tadayuki, Ibusuki Ritsu, Shibahara Daisuke, Otsubo Kohei, Tanaka Kentaro, Okamoto Isamu
细胞生物学
肿瘤
肺癌
肿瘤免疫
发表日期：2025
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Mortality and exacerbation risk according to GOLD and STAR severity stages of COPD: a 5-year multicenter prospective cohort study

根据 GOLD 和 STAR 慢性阻塞性肺疾病严重程度分级评估死亡率和急性加重风险：一项为期 5 年的多中心前瞻性队列研究

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-05033-w
Ogata, Hiroaki; Tsubouchi, Kazuya; Takano, Tomotsugu; Ichiki, Katsuyuki; Torii, Ryo; Takata, Shohei; Nakagaki, Noriaki; Yoshida, Makoto; Kitasato, Yasuhiko; Tobino, Kazunori; Harada, Eiji; Wataya, Hiroshi; Ishii, Hiroshi; Maeyama, Takashige; Kawasaki, Masayuki; Fujita, Masaki; Yatera, Kazuhiro; Zaizen, Yoshiaki; Nakanishi, Yoichi; Okamoto, Isamu
STAR
慢性阻塞性肺疾病
发表日期：2025
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