日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Drug Repurposing Screen Identifies Pimozide as a ROS-Inducing Therapy With Anti-Tumor Efficacy in HNSCC PDX Models

药物再利用筛选发现匹莫齐特是一种ROS诱导疗法，在头颈部鳞状细胞癌PDX模型中具有抗肿瘤疗效

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.70253
Okazaki, Shogo; Nakamura, Shintaro; Soma, Tomoya; Yoshikawa, Momoko; Asoda, Seiji; Nakajima, Yurika; Tsuchihashi, Kenji; Ohmura, Mitsuyo; Goitsuka, Ryo; Imai, Kenichi; Saya, Hideyuki; Nagano, Osamu; Ozawa, Hiroyuki
细胞生物学
肿瘤
肿瘤免疫
发表日期：2026
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Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

利用球状体培养和LATS抑制技术建立牙龈卟啉单胞菌与头颈部鳞状细胞癌的共培养体系

期刊:FEBS Open Bio
影响因子:2.3
doi:10.1002/2211-5463.70154
Nakajima, Yurika; Okazaki, Shogo; Tamura, Muneaki; Sato, Shuichi; Imai, Kenichi
细胞生物学
肿瘤
LAT
肿瘤免疫
发表日期：2026
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Benzaldehyde suppresses epithelial-mesenchymal plasticity and overcomes treatment resistance in cancer by targeting the interaction of 14-3-3ζ with H3S28ph

苯甲醛通过靶向14-3-3ζ与H3S28ph的相互作用，抑制上皮-间质可塑性并克服癌症治疗耐药性。

期刊:British Journal of Cancer
影响因子:6.8
doi:10.1038/s41416-025-03006-4
Saito, Jun; Onishi, Nobuyuki; Yamasaki, Juntaro; Koike, Naoyoshi; Hata, Yukie; Kimura, Kiyomi; Otsuki, Yuji; Nobusue, Hiroyuki; Sampetrean, Oltea; Shimizu, Takatsune; Okazaki, Shogo; Sugihara, Eiji; Saya, Hideyuki
肿瘤
肿瘤免疫
治疗耐药
发表日期：2025
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Mipep deficiency in adipocytes impairs mitochondrial protein maturation and leads to systemic inflammation and metabolic dysfunctions.

脂肪细胞中 Mipep 缺乏会损害线粒体蛋白的成熟，并导致全身炎症和代谢功能障碍

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-97307-6
Nozaki Yuka, Kobayashi Masaki, Fukuoh Tomoyoshi, Ishimatsu Mamiko, Narita Takumi, Taki Kanari, Hirao Yuto, Ayabe Shota, Yokoyama Miku, Otani Yuina, Mizunoe Yuhei, Matsumoto Mami, Ohno Nobuhiko, Kaifu Tomonori, Okazaki Shogo, Goitsuka Ryo, Nakagawa Yoshimi, Shimano Hitoshi, Iwakura Yoichiro, Higami Yoshikazu
代谢
细胞生物学
炎症
线粒体
发表日期：2025
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CD44v, S1PR1, HER3, MET and cancer-associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb.

CD44v、S1PR1、HER3、MET 和癌症相关氨基酸转运体是使用 mAb 表征的胰腺癌的有希望的靶点

期刊:FEBS Open Bio
影响因子:2.3
doi:10.1002/2211-5463.13963
Nakano Takashi, Okita Kouki, Okazaki Shogo, Yoshimoto Soshi, Masuko Sachiko, Yagi Hideki, Kato Kazunori, Tomioka Yoshihisa, Imai Kenichi, Hamada Yoichi, Masuko Kazue, Shimada-Takaura Kayoko, Nagai Noriaki, Saya Hideyuki, Arai Tomio, Ishiwata Toshiyuki, Masuko Takashi
肿瘤
胰腺癌
CD4
CD44
发表日期：2025
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HER4 and EGFR Activate Cell Signaling in NRG1 Fusion-Driven Cancers: Implications for HER2-HER3-specific Versus Pan-HER Targeting Strategies

HER4 和 EGFR 激活 NRG1 融合驱动癌症中的细胞信号传导：对 HER2-HER3 特异性靶向与泛 HER 靶向策略的启示

期刊:Journal of Thoracic Oncology
影响因子:20.8
doi:10.1016/j.jtho.2023.08.034
Udagawa, Hibiki; Nilsson, Monique B; Robichaux, Jacqulyne P; He, Junqin; Poteete, Alissa; Jiang, Hong; Heeke, Simon; Elamin, Yasir Y; Shibata, Yuji; Matsumoto, Shingo; Yoh, Kiyotaka; Okazaki, Shogo; Masuko, Takashi; Odintsov, Igor; Somwar, Romel; Ladanyi, Marc; Goto, Koichi; Heymach, John V
肿瘤
HER2
肿瘤免疫
信号转导
EGF
EGFR
细胞生物学
发表日期：2024
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MEK inhibition suppresses metastatic progression of KRAS-mutated gastric cancer

MEK抑制剂可抑制KRAS突变型胃癌的转移进展

期刊:Cancer Science
影响因子:4.3
doi:10.1111/cas.15244
Yamasaki, Juntaro; Hirata, Yuki; Otsuki, Yuji; Suina, Kentaro; Saito, Yoshiyuki; Masuda, Kenta; Okazaki, Shogo; Ishimoto, Takatsugu; Saya, Hideyuki; Nagano, Osamu
胃癌
RAS
肿瘤
肿瘤免疫
发表日期：2022
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Novel functional anti-HER3 monoclonal antibodies with potent anti-cancer effects on various human epithelial cancers

新型功能性抗HER3单克隆抗体对多种人类上皮癌具有强效抗癌作用

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.27414
Okita, Kouki; Okazaki, Shogo; Uejima, Shinya; Yamada, Erina; Kaminaka, Hiroki; Kondo, Misa; Ueda, Shiho; Tokiwa, Ryo; Iwata, Nami; Yamasaki, Akitaka; Hayashi, Natsumi; Ogura, Dai; Hirotani, Kenji; Yoshioka, Toshiaki; Inoue, Masahiro; Masuko, Kazue; Masuko, Takashi
单克隆抗体
肿瘤
肿瘤免疫
发表日期：2020
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CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

CD44变体通过减弱LAT1介导的氨基酸摄取来抑制胰岛β细胞的胰岛素分泌。

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-018-20973-2
Kobayashi, Nana; Okazaki, Shogo; Sampetrean, Oltea; Irie, Junichiro; Itoh, Hiroshi; Saya, Hideyuki
T细胞
LAT
LAT1
CD44
细胞生物学
CD4
免疫/内分泌
发表日期：2018
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Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

ALDH3A1抑制剂dyclonine和xCT抑制剂在谷胱甘肽缺乏耐药癌细胞中的合成致死性

期刊:Oncotarget
影响因子:
doi:10.18632/oncotarget.26112
Okazaki, Shogo; Shintani, Subaru; Hirata, Yuki; Suina, Kentaro; Semba, Takashi; Yamasaki, Juntaro; Umene, Kiyoko; Ishikawa, Miyuki; Saya, Hideyuki; Nagano, Osamu
ALDH
细胞生物学
肿瘤
肿瘤免疫
发表日期：2018
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